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Alcohol dehydrogenase 1B Aldehyde dehydrogenase, mitochondrial Aldehyde dehydrogenase X, mitochondrial Cytochrome P450 2E1 Aldehyde dehydrogenase, mitochondrial Catalase Aldehyde dehydrogenase, mitochondrial Acetyl-coenzyme A synthetase, cytoplasmic Acetyl-coenzyme A synthetase 2-like, mitochondrial Acetaldehyde Acetaldehyde Ethanol Ethanol Acetic acid Acetic acid Acetic acid Acetic acid Ethanol NAD Acetaldehyde NADH H+ NAD H2O NADH H+ O2 NADPH H2O NADP NAD H2O NADH H+ Ethanol H2O2 Acetaldehyde H2O NAD H2O NADH H+ ATP CoA AMP PPi Acetyl-CoA ATP CoA AMP PPi Zinc (II) ion Heme NADP Heme Extra Hepatic Cell Hepatic Cell (I) Hepatic Cell (II) Hepatic Cell (III) Endoplasmic Reticulum Peroxisome Mitochondria Mitochondria Cytoplasm Liver
Endoplasmic Reticulum ADH1B ALDH2 ALDH1B1 CYP2E1 ALDH2 CAT ALDH2 ACSS2 ACSS1 Acetaldehyde Acetaldehyde Ethanol Ethanol Acetic acid Acetic acid Acetic acid Acetic acid Ethanol NAD Acetaldehyde NADH Hydrogen Ion NAD Water NADH Hydrogen Ion Oxygen NADPH Water NADP NAD Water NADH Hydrogen Ion Ethanol Hydrogen peroxide Acetaldehyde Water NAD Water NADH Hydrogen Ion Adenosine triphosphate Coenzyme A Adenosine monophosphate Pyrophosphate Acetyl-CoA Adenosine triphosphate Coenzyme A Adenosine monophosphate Pyrophosphate
ADH1B ALDH2 ALDH1B1 CYP2E1 ALDH2 CAT ALDH2 ACSS2 ACSS1 Ethanal Ethanal Ethanol Ethanol Acoh Acoh Acoh Acoh Ethanol NAD Ethanal NADH H+ NAD H2O NADH H+ O2 NADPH H2O NADP NAD H2O NADH H+ Ethanol H2O2 Ethanal H2O NAD H2O NADH H+ ATP CoA AMP PPi Ac-CoA ATP CoA AMP PPi Zinc Heme NADP Heme Extra Hepatic Cell Hepatic Cell (I) Hepatic Cell (II) Hepatic Cell (III) Endoplasmic Reticulum Peroxisome Mitochondria Mitochondria Cytoplasm Liver
Endoplasmic Reticulum ADH1B ALDH2 ALDH1B1 CYP2E1 ALDH2 CAT ALDH2 ACSS2 ACSS1 Ethanal Ethanal Ethanol Ethanol Acoh Acoh Acoh Acoh Ethanol NAD Ethanal NADH H+ NAD H2O NADH H+ O2 NADPH H2O NADP NAD H2O NADH H+ Ethanol H2O2 Ethanal H2O NAD H2O NADH H+ ATP CoA AMP Ppi Ac-CoA ATP CoA AMP Ppi