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Aldo-keto reductase family 1 member C4 3-oxo-5-beta- steroid 4-dehydrogenase Cytochrome P450 11B2, mitochondrial Cytochrome P450 11B1, mitochondrial Aldo-keto reductase family 1 member C4 Corticosteroid 11-beta- dehydrogenase isozyme 1 Aldo-keto reductase family 1 member C4 Steroid 21-hydroxylase Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial 3-beta-HSD 1 Steroid 21-hydroxylase 3-beta-HSD 1 Cytochrome P450 11B2, mitochondrial Steroid 21-hydroxylase Cytochrome P450 11B1, mitochondrial Cytochrome P450 11B1, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase 3-beta-HSD 1 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 21-hydroxylase Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Cholesterol side-chain cleavage enzyme, mitochondrial Steroid 17-alpha- hydroxylase/17,20 lyase 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 Cytochrome P450 11B1, mitochondrial 3-oxo-5-beta- steroid 4-dehydrogenase Aldo-keto reductase family 1 member C4 Corticosteroid 11-beta- dehydrogenase isozyme 2 Corticosteroid 11-beta- dehydrogenase isozyme 2 3 beta- hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21-Dihydroxy-3,20-oxo- 5b-pregnan-18-al NADPH 3a,11b,21-Trihydroxy-20-oxo- 5b-pregnan-18-al NADP NADP Aldosterone NADPH Accumulation 18-Hydroxycorticosterone O2 H2O Accumulation Corticosterone O2 H2O 11b,21-Dihydroxy-5b- pregnane-3,20-dione Tetrahydrocorticosterone NADP NADPH 11-Dehydrocorticosterone 21-Hydroxy-5b-pregnane- 3,11,20-trione NADP 3a,21-Dihydroxy-5b-pregnane- 11,20-dione NADPH NADP NADPH 11b-Hydroxyprogesterone 21-Deoxycortisol Dissipation Cortisol Deoxycorticosterone 21-Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH Dissipation 17-Hydroxyprogesterone Dissipation Cortexolone Dissipation 17a-Hydroxypregnenolone NAD NADH NADH 17α,21-Dihydroxypregnenolone NAD 20a,22b-Dihydroxycholesterol 4-Methylpentanal 17a,20a-Dihydroxycholesterol 22b-Hydroxycholesterol 20α-Hydroxycholesterol 17a,21-Dihydroxy-5b- pregnane-3,11,20-trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH O2 11b,17a,21-Trihydroxypreg- nenolone H2O NADPH 5a-Pregnane-3,20-dione NADP 3a-Hydroxy-5b-pregnane-20-one NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Steroid Biosynthesis Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Inner mitochondria membrane Outer mitochondria membrane Adrenal Cell
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum AKR1C4 AKR1D1 CYP11B2 CYP11B1 AKR1C4 HSD11B1 AKR1C4 CYP21A2 CYP17A1 CYP21A2 CYP11B1 HSD3B1 CYP21A2 HSD3B1 CYP11B2 CYP21A2 CYP11B1 CYP11B1 CYP17A1 CYP21A2 HSD3B1 HSD3B1 CYP17A1 CYP21A2 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 AKR1D1 AKR1C4 AKR1D1 AKR1C4 CYP11B1 AKR1D1 AKR1C4 HSD11B2 HSD11B2 HSD3B2 Cholesterol Accumulation Progesterone Accumulation Progesterone 11b,21- Dihydroxy- 3,20-oxo-5b- pregnan-18-al NADPH 3a,11b,21- Trihydroxy- 20-oxo-5b- pregnan-18-al NADP NADP Aldosterone NADPH Accumulation 18- Hydroxycorticosterone Oxygen Water Accumulation Corticosterone Oxygen Water 11b,21- Dihydroxy-5b- pregnane- 3,20-dione Tetrahydrocorticosterone NADP NADPH 11- Dehydrocorticosterone 21-Hydroxy- 5b-pregnane- 3,11,20- trione NADP 3a,21- Dihydroxy-5b- pregnane- 11,20-dione NADPH NADP NADPH 11b- Hydroxyprogesterone 21- Deoxycortisol Dissipation Cortisol Deoxycorticosterone 21- Hydroxypregnenolone NAD NADH Accumulation Pregnenolone NAD NADH Dissipation 17- Hydroxyprogesterone Dissipation Cortexolone Dissipation 17a- Hydroxypregnenolone NAD NADH NADH 17α,21- Dihydroxypregnenolone NAD 20a,22b- Dihydroxycholesterol 4- Methylpentanal 17a,20a- Dihydroxycholesterol 22b- Hydroxycholesterol 20α- Hydroxycholesterol 17a,21- Dihydroxy-5b- pregnane- 3,11,20- trione NADP Cortisone NADPH Tetrahydrocortisone NADP NADPH Dihydrocortisol NADP NADPH Tetrahydrocortisol NADP NADPH Oxygen 11b,17a,21- Trihydroxypreg- nenolone Water NADPH 5a-Pregnane- 3,20-dione NADP 3a-Hydroxy- 5b-pregnane- 20-one NADP NADPH NADP NADPH Steroid Biosynthesis
AKR1C4 AKR1D1 CYP11B2 CYP11B1 AKR1C4 HSD11B1 AKR1C4 CYP21A2 CYP17A1 CYP21A2 CYP11B1 HSD3B1 CYP21A2 HSD3B1 CYP11B2 CYP21A2 CYP11B1 CYP11B1 CYP17A1 CYP21A2 HSD3B1 HSD3B1 CYP17A1 CYP21A2 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 AKR1D1 AKR1C4 AKR1D1 AKR1C4 CYP11B1 AKR1D1 AKR1C4 HSD11B2 HSD11B2 HSD3B2 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH Accumulation 18-HCC O2 H2O Accumulation Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt Dissipation HC Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH Dissipation 17-OHP Dissipation Cortexo Dissipation 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme PW000050 Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Adrenal Gland Smooth Endoplasmic Reticulum Smooth Endoplasmic Reticulum ER Membrane ER Membrane ER Membrane Mitochondrion Mitochondrion Mitochondrion Mitochondrion Intracellular Space Inner mitochondria membrane Outer mitochondria membrane Adrenal Cell
Endoplasmic Reticulum Mitochondria Endoplasmic Reticulum AKR1C4 AKR1D1 CYP11B2 CYP11B1 AKR1C4 HSD11B1 AKR1C4 CYP21A2 CYP17A1 CYP21A2 CYP11B1 HSD3B1 CYP21A2 HSD3B1 CYP11B2 CYP21A2 CYP11B1 CYP11B1 CYP17A1 CYP21A2 HSD3B1 HSD3B1 CYP17A1 CYP21A2 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP11A1 CYP17A1 AKR1D1 AKR1C4 AKR1D1 AKR1C4 CYP11B1 AKR1D1 AKR1C4 HSD11B2 HSD11B2 HSD3B2 Lanol Accumulation Prgstrn Accumulation Prgstrn NA NADPH T20OPal NADP NADP Aldostr NADPH Accumulation 18-HCC O2 H2O Accumulation Cortcos O2 H2O 11B21D5 Tetrahy NADP NADPH 11dhccn 21-Hydr NADP 321D5B NADPH NADP NADPH 11Hprgt 21HOCrt Dissipation HC Doct 21-Hpgn NAD NADH Accumulation Pregnen NAD NADH Dissipation 17-OHP Dissipation Cortexo Dissipation 17a-HP NAD NADH NADH 17ADhp NAD OH2chol 4-MPnal 17aDhch 22b-HC 20a-HC DHPRGT NADP Corlin NADPH TetraHC NADP NADPH DHCort NADP NADPH tetHCol NADP NADPH O2 Trihpnn H2O NADPH P3D NADP 3aH5bPO NADP NADPH NADP NADPH PW000050