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Alcohol dehydrogenase 1A Retinol dehydrogenase 12 Dehydrogenase/reductase SDR family member 4 Retinol dehydrogenase 16 Retinol dehydrogenase 8 Short-chain dehydrogenase/reductase 3 Dehydrogenase/reductase SDR family member 9 Retinol dehydrogenase 11 Lecithin retinol acyltransferase Acyl-CoA wax alcohol acyltransferase 1 Diacylglycerol O- acyltransferase 1 Retinoid isomerohydrolase Diacylglycerol O- acyltransferase 1 Acyl-CoA wax alcohol acyltransferase 1 Lecithin retinol acyltransferase Retinol dehydrogenase 11 Patatin-like phospholipase domain- containing protein 4 Beta,beta- carotene 15,15'- monooxygenase Retinol dehydrogenase 11 Retinol dehydrogenase 11 Dehydrogenase/reductase SDR family member 4 Retinal dehydrogenase 1 Retinal dehydrogenase 2 Retinal dehydrogenase 1 Retinal dehydrogenase 2 Cytochrome P450 26A1 All-trans- retinol 13,14-reductase UDP- glucuronosyltransferase 1-1 Cytochrome P450 26A1 Cytochrome P450 26A1 Cytochrome P450 26A1 Cytochrome P450 11-cis-Retinaldehyde NAD Dissipation Retinal NADH NADP NADPH NADP NADPH NADP NADPH NADP 11-cis-Retinol NADPH PC(24:1(15Z)/15:0) Retinyl palmitate Glycerophosphocholine Acetyl-CoA CoA Acetyl-CoA CoA Retinyl ester H2O Dissipation Vitamin A Acetyl-CoA CoA Acetyl-CoA CoA PC(24:1(15Z)/15:0) Glycerophosphocholine NADP NADPH DG(16:1(9Z)/22:0/0:0) TG(16:1(9Z)/22:0/16:1(9Z)) 9-cis-Retinol B-Carotene O2 NADP 9-cis-Retinal NADPH NADP NADPH NADP NADPH NAD H2O 9-cis-Retinoic acid NADH NAD H2O NADH NAD H2O all-trans-Retinoic acid NADH NAD H2O NADH 4-Oxoretinol All-trans-13,14-dihydroretinol Retinoyl b-glucuronide 4-Hydroxyretinoic acid 4-oxo-Retinoic acid all-trans-18-Hydroxyretinoic acid all-trans-5,6-Epoxyretinoic acid Zinc NADP NAD NADP NAD Fe2+ Heme Heme Heme Heme Fatty Acid Reduced acceptor Acceptor Reduced acceptor Acceptor Rhodopsin Bathorodopsin iodopsin Lumirodopsin Metarodopsin Heme NAD Fe2+ hv hv Intracellular Space Endoplasmic Reticulum Endoplasmic Reticulum
ADH1A RDH12 DHRS4 RDH16 RDH8 DHRS3 DHRS9 RDH11 LRAT AWAT1 DGAT1 RPE65 DGAT1 AWAT1 LRAT RDH11 PNPLA4 BCMO1 RDH11 RDH11 DHRS4 ALDH1A1 ALDH1A2 ALDH1A1 ALDH1A2 CYP26A1 RETSAT DNAJB11 HSP90B1 HSPA5 HYOU1 PDIA2 PDIA4 PDIA6 PPIB SDF2L1 UGT1A1 ERP29 CYP26A1 CYP26A1 CYP26A1 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP3A7 CYP3A4 CYP3A5 CYP3A43 11-cis- Retinaldehyde NAD Dissipation Retinal NADH NADP NADPH NADP NADPH NADP NADPH NADP 11-cis-Retinol NADPH PC(24:1(15Z)/15:0) Retinyl palmitate Glycerophosphocholine Acetyl-CoA Coenzyme A Acetyl-CoA Coenzyme A Retinyl ester Water Dissipation Vitamin A Acetyl-CoA Coenzyme A Acetyl-CoA Coenzyme A PC(24:1(15Z)/15:0) Glycerophosphocholine NADP NADPH DG(16:1(9Z)/22:0/0:0) TG(16:1(9Z)/22:0/16:1(9Z)) 9-cis-Retinol B-Carotene Oxygen NADP 9-cis-Retinal NADPH NADP NADPH NADP NADPH NAD Water 9-cis-Retinoic acid NADH NAD Water NADH NAD Water all-trans- Retinoic acid NADH NAD Water NADH 4-Oxoretinol All-trans- 13,14- dihydroretinol Retinoyl b-glucuronide 4- Hydroxyretinoic acid 4-oxo-Retinoic acid all-trans-18- Hydroxyretinoic acid all-trans- 5,6- Epoxyretinoic acid Fatty Acid Reduced acceptor Acceptor Reduced acceptor Acceptor Rhodopsin Bathorodopsin iodopsin Lumirodopsin Metarodopsin
ADH1A RDH12 DHRS4 RDH16 RDH8 DHRS3 DHRS9 RDH11 LRAT AWAT1 DGAT1 RPE65 DGAT1 AWAT1 LRAT RDH11 PNPLA4 BCMO1 RDH11 RDH11 DHRS4 ALDH1A1 ALDH1A2 ALDH1A1 ALDH1A2 CYP26A1 RETSAT DNAJB11 HSP90B1 HSPA5 HYOU1 PDIA2 PDIA4 PDIA6 PPIB SDF2L1 UGT1A1 ERP29 CYP26A1 CYP26A1 CYP26A1 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP3A7 CYP3A4 CYP3A5 CYP3A43 C-RetAl NAD Dissipation Retinal NADH NADP NADPH NADP NADPH NADP NADPH NADP C-retol NADPH PC241 Retylpm GPC Ac-CoA CoA Ac-CoA CoA RetEst H2O Dissipation Retinol Ac-CoA CoA Ac-CoA CoA PC241 GPC NADP NADPH DG38:1 TG54:2 9-c-Rol b-carot O2 NADP 9-c-Ral NADPH NADP NADPH NADP NADPH NAD H2O Airol NADH NAD H2O NADH NAD H2O T-RetcA NADH NAD H2O NADH 4ORetol ATdhret RetybGu 4HRetA 4ORetA AT18HA alt56eA Zinc NADP NAD NADP NAD Fe2+ Heme Heme Heme Heme FA RA Accepto RA Accepto Rhodops Bathoro Iodopsi Lumirod Metarod Heme NAD Fe2+ hv hv Intracellular Space Endoplasmic Reticulum Endoplasmic Reticulum
ADH1A RDH12 DHRS4 RDH16 RDH8 DHRS3 DHRS9 RDH11 LRAT AWAT1 DGAT1 RPE65 DGAT1 AWAT1 LRAT RDH11 PNPLA4 BCMO1 RDH11 RDH11 DHRS4 ALDH1A1 ALDH1A2 ALDH1A1 ALDH1A2 CYP26A1 RETSAT DNAJB11 HSP90B1 HSPA5 HYOU1 PDIA2 PDIA4 PDIA6 PPIB SDF2L1 UGT1A1 ERP29 CYP26A1 CYP26A1 CYP26A1 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP3A7 CYP3A4 CYP3A5 CYP3A43 C-RetAl NAD Dissipation Retinal NADH NADP NADPH NADP NADPH NADP NADPH NADP C-retol NADPH PC241 Retylpm GPC Ac-CoA CoA Ac-CoA CoA RetEst H2O Dissipation Retinol Ac-CoA CoA Ac-CoA CoA PC241 GPC NADP NADPH DG38:1 TG54:2 9-c-Rol b-carot O2 NADP 9-c-Ral NADPH NADP NADPH NADP NADPH NAD H2O Airol NADH NAD H2O NADH NAD H2O T-RetcA NADH NAD H2O NADH 4ORetol ATdhret RetybGu 4HRetA 4ORetA AT18HA alt56eA FA RA Accepto RA Accepto Rhodops Bathoro Iodopsi Lumirod Metarod