Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Ifosfamide Action Pathway
Homo sapiens
Drug Action Pathway
Ifosfamide is an alkylating agent used in the treatment of certain cancers. Following absorption, ifosfamide is converted into 4-hydroxyifosfamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyifosfamide crosses the plasma membrane of the cancer cell and spontaneuosly forms aldoifosfamide. This is a reversible reaction. Aldoifosfamide can decompose into acrolein and ifosforamide mustard. Ifosforamide mustard is the active alkylating agent and forms alkyl adducts with DNA through an ifosforamide aziridinium intermediate. Alkylation of DNA causes DNA damage and ultimately cell death.
References
Ifosfamide Pathway References
Fleming RA: An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy. 1997 Sep-Oct;17(5 Pt 2):146S-154S.
Pubmed: 9322882
Jing Z, Quan T: Clinical Pharmacology of Cyclophosphamide and Ifosfamide. Current Drug Therapy. 2006;1(1):55-84. doi: 10.2174/157488506775268515.
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings