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Pathway Description
Diflunisal Action Pathway
Homo sapiens
Drug Action Pathway
Diflunisal (also known as Dolobid) is a prostaglandin G/H synthase inhibitor that can inhibit prostaglandin G/H synthase 1 and 2 which prevent the production of prostaglandin. Therefore, diflunisal can be used for treating prostaglandin-associated pain, fever, swelling, platelet aggregation and inflammation. Diflunisal can also inhibit the relocation of leukocytes to inflammation site and also the production of the aggregating agent of platelets: thromboxane A2.
References
Diflunisal Pathway References
Botting, R., & Botting, J. Cyclooxygenases. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p.279-283. Berlin, Germany: Springer.
Breyer, R.M., & Breyer, M.D. Prostanoids. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 752-757. Berlin, Germany: Springer.
Diflunisal (CPhA monograph). (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved August 15, 2009.
Hannah J, Ruyle WV, Jones H, Matzuk AR, Kelly KW, Witzel BE, Holtz WJ, Houser RW, Shen TY, Sarett LH: Discovery of diflunisal. Br J Clin Pharmacol. 1977 Feb;4 Suppl 1:7S-13S. doi: 10.1111/j.1365-2125.1977.tb04508.x.
Pubmed: 328036
Majerus PW, Stanford N: Comparative effects of aspirin and diflunisal on prostaglandin synthetase from human platelets and sheep seminal vesicles. Br J Clin Pharmacol. 1977 Feb;4 Suppl 1:15S-18S. doi: 10.1111/j.1365-2125.1977.tb04509.x.
Pubmed: 406909
Shen TY: Chemical and Pharmacological Properties of Diflunisal. Pharmacotherapy. 1983 Mar;3(2 Pt 2):3S-8S. doi: 10.1002/phar.1983.3.2p2.3.
Pubmed: 29112309
Schulz P, Perrier CV, Ferber-Perret F, VandenHeuvel WJ, Steelman SL: Diflunisal, a new-acting analgesic and prostaglandin inhibitor: effect of concomitant acetylsalicylic acid therapy on ototoxicity and on disposition of both drugs. J Int Med Res. 1979;7(1):61-8. doi: 10.1177/030006057900700110.
Pubmed: 311303
Arachidonic Acid Metabolism References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Vance, D.E., and Vance, J.E. Biochemistry of lipids, lipoproteins, and membranes (4th ed.) (2002) Amsterdam; Boston: Elsevier.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
Kroetz DL, Zeldin DC: Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol. 2002 Jun;13(3):273-83.
Pubmed: 12045397
Zeldin DC: Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem. 2001 Sep 28;276(39):36059-62. doi: 10.1074/jbc.R100030200. Epub 2001 Jul 12.
Pubmed: 11451964
Ondrey FG: Arachidonic acid metabolism: a primer for head and neck surgeons. Head Neck. 1998 Jul;20(4):334-49.
Pubmed: 9588707
Sigal E: The molecular biology of mammalian arachidonic acid metabolism. Am J Physiol. 1991 Feb;260(2 Pt 1):L13-28. doi: 10.1152/ajplung.1991.260.2.L13.
Pubmed: 1899973
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