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Pathway Description
Heparin.
Homo sapiens
Drug Action Pathway
Heparin (also named unfractionated heparin or Clexane) is an anticoagulant medication. The main mechanism of heparin is acting on increasing the rate of antithrombin-related neutralization of coagulation factors for certain activated type. More specifically, heparin will bind to the antithrombin III (AT) that make antithrombin III changing to its activated form. Activated antithrombin III will inactive prothrombin and factor Xa (also other proteases).
References
Heparin. References
Heparin: Unfractionated. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved June 26, 2009.
Jennings LK, Saucedo JF: Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol. 2008 Jul;23(4):302-8. doi: 10.1097/HCO.0b013e3283021ad9.
Pubmed: 18520712
Walker CP, Royston D: Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies. Br J Anaesth. 2002 Jun;88(6):848-63.
Pubmed: 12173205
Coagulation References
van der Meijden PE, Munnix IC, Auger JM, Govers-Riemslag JW, Cosemans JM, Kuijpers MJ, Spronk HM, Watson SP, Renne T, Heemskerk JW: Dual role of collagen in factor XII-dependent thrombus formation. Blood. 2009 Jul 23;114(4):881-90. doi: 10.1182/blood-2008-07-171066. Epub 2009 Apr 16.
Pubmed: 19372258
Norris LA: Blood coagulation. Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
Pubmed: 12787532
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