PathWhiz

Pathway Description

Prednisone Action Pathway

Homo sapiens

Drug Action Pathway

Prednisone is a medication that is used to suppress the immune system. It works by interrupting cytokine pathways type 1 and type 2. It is administered orally, through tablet, or solution (concentrated or non-concentrated). Prednisone is a glucocorticoid, and as well as being used for immune system suppression, it is used for its anti inflammatory properties. It exerts these properties by binding to glucocorticoid receptors in the cell, which inhibits inflammatory cells. This prevents inflammatory mediators from being expressed.

References

Prednisone Pathway References

Barnes PJ, Adcock IM: Glucocorticoid resistance in inflammatory diseases. Lancet. 2009 May 30;373(9678):1905-17. doi: 10.1016/S0140-6736(09)60326-3.

Pubmed: 19482216

Frey BM, Frey FJ: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46. doi: 10.2165/00003088-199019020-00003.

Pubmed: 2199128

Pujolsa L, Mullol J, Picado C: Glucocorticoid receptor in human respiratory epithelial cells. Neuroimmunomodulation. 2009;16(5):290-9. doi: 10.1159/000216187. Epub 2009 Jun 29.

Pubmed: 19571590

Highlighted elements will appear in red.

Highlight Compounds

	Heme
	Hydrogen Ion
	Prednisolone
	Prednisone

Highlight Proteins

Cytochrome P450 3A4

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