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Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Bcl2-associated agonist of cell death Adenosine receptor A2b Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p100 subunit Nuclear factor NF-kappa-B p100 subunit Adenosine receptor A2b Adenosine receptor A2b Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Adenylate cyclase type 2 Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 2 cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit beta Rap guanine nucleotide exchange factor 3 Ras-related protein Rap-1A Ras-related protein Rap-1A Rap guanine nucleotide exchange factor 3 Serine/threonine- protein kinase B-raf Serine/threonine- protein kinase B-raf Ras-related protein Rap-1A Dual specificity mitogen- activated protein kinase kinase 2 Dual specificity mitogen- activated protein kinase kinase 2 Dual specificity mitogen- activated protein kinase kinase 2 Dual specificity mitogen- activated protein kinase kinase 2 Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 1 ETS domain- containing protein Elk-1 ETS domain- containing protein Elk-1 Rap guanine nucleotide exchange factor 2 Rap guanine nucleotide exchange factor 2 GTPase HRas GTPase HRas Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform GTPase HRas Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Cyclic AMP-responsive element-binding protein 1 Cyclic AMP-responsive element-binding protein 1 Rho guanine nucleotide exchange factor 7 Rho guanine nucleotide exchange factor 7 Cell division control protein 42 homolog Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 4 Mitogen- activated protein kinase kinase kinase 4 Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 1 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 7 Dual specificity mitogen- activated protein kinase kinase 7 Mitogen- activated protein kinase 8 Mitogen- activated protein kinase 8 Transcription factor AP-1 Transcription factor AP-1 Serine/threonine- protein kinase PAK 1 Cell division control protein 42 homolog Serine/threonine- protein kinase PAK 1 Dual specificity mitogen- activated protein kinase kinase 6 Dual specificity mitogen- activated protein kinase kinase 6 Mitogen- activated protein kinase 11 Mitogen- activated protein kinase 11 Cyclic AMP-dependent transcription factor ATF-2 Cyclic AMP-dependent transcription factor ATF-2 3- phosphoinositide- dependent protein kinase 1 3- phosphoinositide- dependent protein kinase 1 RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase RAC-alpha serine/threonine- protein kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p100 subunit Partitioning defective 6 homolog alpha Protein kinase C zeta type Cell division control protein 42 homolog Partitioning defective 6 homolog alpha Protein kinase C zeta type Ribosomal protein S6 kinase alpha-1 Ribosomal protein S6 kinase alpha-1 Bcl2-associated agonist of cell death cAMP Adenosine Adenosine GTP GDP Adenosine triphosphate PPi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP2(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP3(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP Guanosine triphosphate Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Zinc Zinc Magnesium Magnesium cAMP Guanosine diphosphate Guanosine triphosphate Guanosine triphosphate Phosphate Guanosine diphosphate Guanosine triphosphate Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Magnesium Magnesium Magnesium Magnesium Magnesium Guanosine triphosphate Regulation of glutamate and Dopamine release in the brain Coronary artery vasodilation in the heart Apoptosis cAMP Transcription Transcription Transcription Transcription Transcription Nucleus Intracellular Space Extracellular Space Activation Activation Activation Activation Regulatory Subunit Regulatory Subunit Inhibition
GNAS GNG12 GNB1 BAD ADORA2B NFKB1 NFKB1 NFKB2 NFKB2 ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY2 GNAS ADCY2 PRKACB PRKACB RAPGEF3 RAP1A RAP1A RAPGEF3 BRAF BRAF RAP1A MAP2K2 MAP2K2 MAP2K2 MAP2K2 MAPK1 MAPK1 ELK1 ELK1 RAPGEF2 RAPGEF2 HRAS HRAS PIK3CA HRAS PIK3CA CREB1 CREB1 ARHGEF7 ARHGEF7 CDC42 CDC42 MAP3K4 MAP3K4 CDC42 MAP3K1 MAP3K1 MAP2K7 MAP2K7 MAPK8 MAPK8 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK11 MAPK11 ATF2 ATF2 PDPK1 PDPK1 AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIA NFKBIA NFKB1 NFKBIA NFKB2 PARD6A PRKCZ CDC42 PARD6A PRKCZ RPS6KA1 RPS6KA1 BAD cAMP Adenosine Adenosine Guanosine triphosphate Guanosine diphosphate Adenosine triphosphate Pyrophosphate cAMP Guanosine triphosphate Guanosine diphosphate Phosphate Phosphate Phosphate Phosphate Guanosine triphosphate Guanosine diphosphate PIP2(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Phosphate Guanosine triphosphate Guanosine diphosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate PIP3(16:0/16:0) PIP3(16:0/16:0) PIP3(16:0/16:0) Phosphate Phosphate Phosphate Phosphate Phosphate Guanosine diphosphate Guanosine triphosphate Guanosine diphosphate Guanosine triphosphate Guanosine diphosphate Regulation of glutamate and Dopamine release in the brain Coronary artery vasodilation in the heart Apoptosis
GNAS GNG12 GNB1 BAD ADORA2B NFKB1 NFKB1 NFKB2 NFKB2 ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY2 GNAS ADCY2 PRKACB PRKACB RAPGEF3 RAP1A RAP1A RAPGEF3 BRAF BRAF RAP1A MAP2K2 MAP2K2 MAP2K2 MAP2K2 MAPK1 MAPK1 ELK1 ELK1 RAPGEF2 RAPGEF2 HRAS HRAS PIK3CA HRAS PIK3CA CREB1 CREB1 ARHGEF7 ARHGEF7 CDC42 CDC42 MAP3K4 MAP3K4 CDC42 MAP3K1 MAP3K1 MAP2K7 MAP2K7 MAPK8 MAPK8 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK11 MAPK11 ATF2 ATF2 PDPK1 PDPK1 AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIA NFKBIA NFKB1 NFKBIA NFKB2 PARD6A PRKCZ CDC42 PARD6A PRKCZ RPS6KA1 RPS6KA1 BAD cAMP Adenosi Adenosi GTP GDP ATP PPi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP216 PIP316 PIP316 Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP316 PIP316 PIP316 Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP GTP Mg2+ GTP Mg2+ Mg2+ Mg2+ Zinc Zinc Mg2+ Mg2+ cAMP GDP GTP GTP Pi GDP GTP Mg2+ Mg2+ GTP Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ GTP Mg2+ Mg2+ Mg2+ Mg2+ Mg2+ GTP R o g a C a v i Apopt cAMP Transcription Transcription Transcription Transcription Transcription Nucleus Intracellular Space Extracellular Space Activation Activation Activation Activation Regulatory Subunit Regulatory Subunit Inhibition
GNAS GNG12 GNB1 BAD ADORA2B NFKB1 NFKB1 NFKB2 NFKB2 ADORA2B ADORA2B GNG12 GNB1 GNAS GNAS GNG12 GNB1 ADCY2 GNAS ADCY2 PRKACB PRKACB RAPGEF3 RAP1A RAP1A RAPGEF3 BRAF BRAF RAP1A MAP2K2 MAP2K2 MAP2K2 MAP2K2 MAPK1 MAPK1 ELK1 ELK1 RAPGEF2 RAPGEF2 HRAS HRAS PIK3CA HRAS PIK3CA CREB1 CREB1 ARHGEF7 ARHGEF7 CDC42 CDC42 MAP3K4 MAP3K4 CDC42 MAP3K1 MAP3K1 MAP2K7 MAP2K7 MAPK8 MAPK8 JUN JUN PAK1 CDC42 PAK1 MAP2K6 MAP2K6 MAPK11 MAPK11 ATF2 ATF2 PDPK1 PDPK1 AKT1 AKT1 AKT1 CHUK IKBKB CHUK IKBKB NFKBIA NFKBIA NFKB1 NFKBIA NFKB2 PARD6A PRKCZ CDC42 PARD6A PRKCZ RPS6KA1 RPS6KA1 BAD cAMP Adenosi Adenosi GTP GDP ATP Ppi cAMP GTP GDP Pi Pi Pi Pi GTP GDP PIP216 PIP316 PIP316 Pi GTP GDP Pi Pi Pi Pi Pi Pi Pi PIP316 PIP316 PIP316 Pi Pi Pi Pi Pi GDP GTP GDP GTP GDP R o g a C a v i Apopt