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Pathway Description
Etoposide Metabolism Pathway
Homo sapiens
Drug Metabolism Pathway
Etoposide is a medication commonly sold as Vepesid, or Etopophos. It is a type of chemotherapy. It is used to treat many types of cancers, including nonlymphocytic leukemia and testicular cancer. Etoposide is semisynthetic and a derivative of the podophyllotoxins which is an epipodophyllotoxin. This substance is found in the root of the American Mayapple plant. The way this substance works is by inhibiting topoisomerase II, which inhibits DNA synthesis. This breaks the catalytic cycle of topoisomerase II, and after a while overwhelms the cell. This can cause a death pathway, killing the cancer cell. Etoposide is administered by a doctor, through intravenous infusion.
References
Etoposide Pathway References
Haim N, Roman J, Nemec J, Sinha BK: Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
Pubmed: 3006680
Holthuis JJ: Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics. Pharm Weekbl Sci. 1988 Jun 17;10(3):101-16.
Pubmed: 3047665
Kizaki H, Onishi Y: Topoisomerase II inhibitor-induced apoptosis in thymocytes and lymphoma cells. Adv Enzyme Regul. 1997;37:403-23.
Pubmed: 9381984
Montecucco A, Biamonti G: Cellular response to etoposide treatment. Cancer Lett. 2007 Jul 8;252(1):9-18. doi: 10.1016/j.canlet.2006.11.005. Epub 2006 Dec 12.
Pubmed: 17166655
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