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6022 PubChem-compound 1.0 Cytochrome P450 2D6 937 ChemSpider Cytochrome P450 2E1 P13667 UniProt HMDB60559 HMDB 1.0 HMDB01341 HMDB O15440 UniProt 439153 PubChem-compound SMILES O 1.0 Cytochrome P450 3A4 PW000616 PathWhiz Cytochrome P450 1A2 Stromal cell-derived factor 2-like protein 1 C8H9NO5S Paracetamol sulfate 231.02014 2616-64-0 CAS Cytochrome P450 3A4 UDP-glucuronosyltransferase 2B15 ATP BioCyc 1.0 Uridine diphosphate glucuronic acid SMILES CC(=O)NC1=CC=C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)C=C1 O15439 UniProt 1.0 Water Acetaminophen glucuronide Glutathione S-transferase P CHEBI:15846 ChEBI HMDB00935 HMDB ADP BioCyc Sulfotransferase 1A1 C10H15N5O10P2 Adenosine 3',5'-diphosphate 427.02942 CL:0000182 CELL TYPE ONTOLOGY Cytochrome P450 2A6 BTO:0000759 BRENDA TISSUE ONTOLOGY 39763 PubChem-compound 1.0 5742 ChemSpider C8H7NO2 NAPQI 149.04768 CHEBI:17200 ChEBI C11H14N2O3S Acetaminophen cystein 254.07251 1.0 Endoplasmic reticulum resident protein 29 ReactionCoupledTransportCatalysis74 ACTIVATION ReactionCatalysis1900 ACTIVATION Paracetamol sulfate ReactionCoupledTransportCatalysis79 ACTIVATION HMDB00902 HMDB P11021 UniProt 2.8.2.1 false 2.8.2.1 Acetaminophen + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Paracetamol sulfate LEFT_TO_RIGHT ReactionCoupledTransportCatalysis76 ACTIVATION ReactionCoupledTransportCatalysis75 ACTIVATION 2.4.1.17 false 2.4.1.17 Acetaminophen + Uridine diphosphate glucuronic acid → Acetaminophen glucuronide + Uridine 5'-diphosphate LEFT_TO_RIGHT Phosphoadenosine phosphosulfate 2.0 ReactionCoupledTransportCatalysis78 ACTIVATION CHEBI:16908 ChEBI Glutathione S-transferase theta-1 HMDB59911 HMDB ReactionCoupledTransportCatalysis77 ACTIVATION Phosphate HMDB00125 HMDB UDP-GLUCURONATE BioCyc 6031 PubChem-compound Q6IN67 UniProt O4P Phosphate 94.95342 1.0 1.0 C8H9NO2 Acetaminophen 151.06332 SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O ATP-binding cassette sub-family G member 2 2.0 ReactionCoupledTransportCatalysis80 ACTIVATION 3-5-ADP BioCyc Q9HCN8 UniProt Acetaminophen Metabolism Pathway 1.0 C15H22N2O18P2 Uridine diphosphate glucuronic acid 580.0343 Multidrug resistance-associated protein 1 1053-73-2 CAS P54855 UniProt CHEBI:16856 ChEBI 1.0 124886 PubChem-compound 1.0 1.0 Sulfotransferase 1A3/1A4 2.0 58-68-4 CAS UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 1-9 UDP-glucuronosyltransferase 1-1 Bile salt sulfotransferase SMILES [O-]P([O-])([O-])=O Bile salt sulfotransferase 1.0 GO:0005886 GENE ONTOLOGY 83944 PubChem-compound CHEBI:29132 ChEBI 36356 ChemSpider Q96GW1 UniProt 1.0 NADH C00009 KEGG Compound C00008 KEGG Compound Q13087 UniProt Estrogen sulfotransferase C00001 KEGG Compound Beta-D-Glucuronides BioCyc Q9UBS4 UniProt 1.0 9799 ChemSpider C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider Liver C00002 KEGG Compound ReactionCatalysis1896 ACTIVATION ReactionCatalysis1895 ACTIVATION Protein disulfide-isomerase A6 Cytochrome P450 1A2 ReactionCatalysis1898 ACTIVATION ReactionCatalysis1897 ACTIVATION C10H17N3O6S Glutathione 307.0838 UDP-glucuronosyltransferase 1-6 ReactionCatalysis1899 ACTIVATION 17473 PubChem-compound 159296 PubChem-compound SMILES CC(=O)NC1=CC=C(O)C=C1 HMDB01429 HMDB ReactionCatalysis1894 ACTIVATION Acetaminophen DnaJ homolog subfamily B member 11 Protein disulfide-isomerase A4 HSP90B1 protein C21H28N7O14P2 NAD 664.11694 Sulfotransferase 1A3/1A4 78 kDa glucose-regulated protein Q06520 UniProt C00015 KEGG Compound CHEBI:32636 ChEBI 50700-49-7 CAS Cytochrome P450 2E1 C21H29N7O14P2 NADH 665.12476 Glutathione S-transferase P 1.0 10066-90-7 CAS CHEBI:32635 ChEBI 5957 PubChem-compound BiologicalState53 Multidrug resistance-associated protein 5 Hepatocyte UDP-glucuronosyltransferase 1-1 C06804 KEGG Compound Stromal cell-derived factor 2-like protein 1 1.0 Endoplasmic reticulum resident protein 29 Protein disulfide-isomerase A4 Acetaminophen cystein Protein disulfide-isomerase A6 Peptidyl-prolyl cis-trans isomerase B HYOU1 protein 56-65-5 CAS 53-84-9 CAS Protein disulfide-isomerase A2 Protein disulfide-isomerase A2 78 kDa glucose-regulated protein P08183 UniProt 83939 PubChem-compound Reaction2030 false Acetaminophen + NAD → NADH + NAPQI LEFT_TO_RIGHT C10H15N5O10P2 Adenosine diphosphate 427.02942 Cytochrome P450 2A6 GO:0005737 GENE ONTOLOGY 2.5.1.18 false 2.5.1.18 Glutathione + NAPQI → Acetaminophen cystein + Water LEFT_TO_RIGHT Multidrug resistance-associated protein 4 482-67-7 CAS HYOU1 protein 70-18-8 CAS CHEBI:17985 ChEBI OXIDIZED-GLUTATHIONE BioCyc DnaJ homolog subfamily B member 11 Endoplasmic Reticulum Membrane SMILES CC(O)=NC1=CC=C(SC[C@H](N)C(O)=O)C=C1 CL:0000000 CELL TYPE ONTOLOGY SMILES CC(=O)N=C1C=CC(=O)C=C1 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O UDP-glucuronosyltransferase 1-6 CPD-8587 BioCyc Cytochrome P450 2D6 Sulfotransferase 1A1 5682 ChemSpider UDP BioCyc CHEBI:17980 ChEBI SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:46195 ChEBI O60656 UniProt 1.0 BiologicalState31 HMDB01859 HMDB Adenosine triphosphate P30040 UniProt P22309 UniProt 103-90-2 CAS HMDB60946 HMDB ReactionCatalysis1849 ACTIVATION P09211 UniProt P30711 UniProt Water Paracetamol sulfate C00167 KEGG Compound ReactionCatalysis1852 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis1851 ACTIVATION Multidrug resistance protein 1 Acetaminophen glucuronide NAPQI C00051 KEGG Compound NAD P50225 UniProt C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 P50224 UniProt Cytoplasm HMDB00538 HMDB 83997 PubChem-compound ReactionCatalysis1850 ACTIVATION Cell CHEBI:15422 ChEBI 1.0 C10H15N5O13P2S Phosphoadenosine phosphosulfate 506.98624 HMDB10316 HMDB 1.0 140102 ChemSpider Multidrug resistance-associated protein 5 C00054 KEGG Compound C00053 KEGG Compound 2.0 388299 ChemSpider 7732-18-5 CAS Multidrug resistance-associated protein 4 ReactionCatalysis1863 ACTIVATION ReactionCoupledTransport63 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis1862 ACTIVATION ReactionCoupledTransport62 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT HSP90B1 protein ReactionCoupledTransport65 false Acetaminophen glucuronide + Adenosine triphosphate + Water → Acetaminophen glucuronide + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis1864 ACTIVATION ReactionCoupledTransport64 false Adenosine triphosphate + Paracetamol sulfate + Water → Adenosine diphosphate + Paracetamol sulfate + Phosphate LEFT_TO_RIGHT 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Paracetamol sulfate + Water → Adenosine diphosphate + Paracetamol sulfate + Phosphate LEFT_TO_RIGHT 3.6.3.44 false 3.6.3.44 Acetaminophen glucuronide + Adenosine triphosphate + Water → Acetaminophen glucuronide + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT GO:0005789 GENE ONTOLOGY Estrogen sulfotransferase 75789 ChemSpider NAPQI 16522 ChemSpider ReactionCatalysis1861 ACTIVATION ReactionCoupledTransport61 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 BiologicalState10 Estrogen sulfotransferase Sulfotransferase 1A1 10214 PubChem-compound 16110-10-4 CAS CHEBI:16761 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O 1.0 UDP-glucuronosyltransferase 1-9 9606 TAXONOMY P10635 UniProt 962 PubChem-compound 1.0 5800 ChemSpider 58-98-0 CAS UDP-glucuronosyltransferase 1-1 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O HMDB00295 HMDB 5893 PubChem-compound HMDB02111 HMDB PAPS BioCyc 1.0 2.0 Acetaminophen Glutathione 5809 ChemSpider Glutathione S-transferase theta-1 CHEBI:15377 ChEBI Cell Membrane P05177 UniProt Multidrug resistance-associated protein 1 1.0 1.0 1.0 14265-44-2 CAS P08684 UniProt 1.0 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB00061 HMDB Adenosine 3',5'-diphosphate 1.0 111188 ChemSpider Peptidyl-prolyl cis-trans isomerase B HMDB01487 HMDB 1.0 1.0 75741 ChemSpider P05181 UniProt P11509 UniProt SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)N1C=CC(=O)NC1=O P19224 UniProt P49888 UniProt H2O Water 18.010565 Sulfotransferase 1A3/1A4 SMP00640 SMPDB 1906 ChemSpider 75744 ChemSpider Uridine 5'-diphosphate NADH BioCyc SMILES CC(=O)NC1=CC=C(OS(O)(=O)=O)C=C1 NAD BioCyc HMDB01134 HMDB 1061 PubChem-compound Q9UNQ0 UniProt CHEBI:17659 ChEBI Multidrug resistance protein 1 1.0 Glutathione S-transferase P 1983 PubChem-compound Q15084 UniProt P33527 UniProt P23284 UniProt Glutathione S-transferase theta-1 Adenosine diphosphate Acetaminophen cystein C14H17NO8 Acetaminophen glucuronide 327.09543 1.0 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Cytochrome P450 2E1 Cytochrome P450 1A2 Cytochrome P450 2D6 Cytochrome P450 3A4 Cytochrome P450 2A6 UDP- glucuronosyltransferase 1-9 UDP- glucuronosyltransferase 2B15 UDP- glucuronosyltransferase 1-1 UDP- glucuronosyltransferase 1-6 Glutathione S-transferase P Glutathione S-transferase theta-1 Sulfotransferase 1A1 Estrogen sulfotransferase Bile salt sulfotransferase Sulfotransferase 1A3/1A4 Multidrug resistance- associated protein 1 Multidrug resistance- associated protein 4 Multidrug resistance- associated protein 5 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 Acetaminophen NAD NAPQI NADH Uridine diphosphate glucuronic acid Acetaminophen glucuronide Uridine 5'-diphosphate Glutathione Acetaminophen cystein H 2 O Phosphoadenosine phosphosulfate Paracetamol sulfate Adenosine 3',5'- diphosphate H 2 O ATP Acetaminophen cystein P i ADP H 2 O ATP P i ADP H 2 O ATP P i ADP H 2 O ATP Paracetamol sulfate P i ADP H 2 O ATP P i ADP Acetaminophen glucuronide Heme Heme Heme Heme Heme
6022 PubChem-compound 1.0 Cytochrome P450 2D6 937 ChemSpider Cytochrome P450 2E1 P13667 UniProt HMDB60559 HMDB 1.0 HMDB01341 HMDB O15440 UniProt 439153 PubChem-compound SMILES O 1.0 Cytochrome P450 3A4 PW000616 PathWhiz Cytochrome P450 1A2 Stromal cell-derived factor 2-like protein 1 C8H9NO5S Paracetamol sulfate 231.02014 2616-64-0 CAS Cytochrome P450 3A4 UDP-glucuronosyltransferase 2B15 ATP BioCyc 1.0 Uridine diphosphate glucuronic acid SMILES CC(=O)NC1=CC=C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)C=C1 O15439 UniProt 1.0 Water Acetaminophen glucuronide Glutathione S-transferase P CHEBI:15846 ChEBI HMDB00935 HMDB ADP BioCyc Sulfotransferase 1A1 C10H15N5O10P2 Adenosine 3',5'-diphosphate 427.02942 CL:0000182 CELL TYPE ONTOLOGY Cytochrome P450 2A6 BTO:0000759 BRENDA TISSUE ONTOLOGY 39763 PubChem-compound 1.0 5742 ChemSpider C8H7NO2 NAPQI 149.04768 CHEBI:17200 ChEBI C11H14N2O3S Acetaminophen cystein 254.07251 1.0 Endoplasmic reticulum resident protein 29 ReactionCoupledTransportCatalysis74 ACTIVATION ReactionCatalysis1900 ACTIVATION Paracetamol sulfate ReactionCoupledTransportCatalysis79 ACTIVATION HMDB00902 HMDB P11021 UniProt 2.8.2.1 false 2.8.2.1 Acetaminophen + Phosphoadenosine phosphosulfate → Adenosine 3',5'-diphosphate + Paracetamol sulfate LEFT_TO_RIGHT ReactionCoupledTransportCatalysis76 ACTIVATION ReactionCoupledTransportCatalysis75 ACTIVATION 2.4.1.17 false 2.4.1.17 Acetaminophen + Uridine diphosphate glucuronic acid → Acetaminophen glucuronide + Uridine 5'-diphosphate LEFT_TO_RIGHT Phosphoadenosine phosphosulfate 2.0 ReactionCoupledTransportCatalysis78 ACTIVATION CHEBI:16908 ChEBI Glutathione S-transferase theta-1 HMDB59911 HMDB ReactionCoupledTransportCatalysis77 ACTIVATION Phosphate HMDB00125 HMDB UDP-GLUCURONATE BioCyc 6031 PubChem-compound Q6IN67 UniProt O4P Phosphate 94.95342 1.0 1.0 C8H9NO2 Acetaminophen 151.06332 SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O ATP-binding cassette sub-family G member 2 2.0 ReactionCoupledTransportCatalysis80 ACTIVATION 3-5-ADP BioCyc Q9HCN8 UniProt Acetaminophen Metabolism Pathway 1.0 C15H22N2O18P2 Uridine diphosphate glucuronic acid 580.0343 Multidrug resistance-associated protein 1 1053-73-2 CAS P54855 UniProt CHEBI:16856 ChEBI 1.0 124886 PubChem-compound 1.0 1.0 Sulfotransferase 1A3/1A4 2.0 58-68-4 CAS UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 1-9 UDP-glucuronosyltransferase 1-1 Bile salt sulfotransferase SMILES [O-]P([O-])([O-])=O Bile salt sulfotransferase 1.0 GO:0005886 GENE ONTOLOGY 83944 PubChem-compound CHEBI:29132 ChEBI 36356 ChemSpider Q96GW1 UniProt 1.0 NADH C00009 KEGG Compound C00008 KEGG Compound Q13087 UniProt Estrogen sulfotransferase C00001 KEGG Compound Beta-D-Glucuronides BioCyc Q9UBS4 UniProt 1.0 9799 ChemSpider C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider Liver C00002 KEGG Compound ReactionCatalysis1896 ACTIVATION ReactionCatalysis1895 ACTIVATION Protein disulfide-isomerase A6 Cytochrome P450 1A2 ReactionCatalysis1898 ACTIVATION ReactionCatalysis1897 ACTIVATION C10H17N3O6S Glutathione 307.0838 UDP-glucuronosyltransferase 1-6 ReactionCatalysis1899 ACTIVATION 17473 PubChem-compound 159296 PubChem-compound SMILES CC(=O)NC1=CC=C(O)C=C1 HMDB01429 HMDB ReactionCatalysis1894 ACTIVATION Acetaminophen DnaJ homolog subfamily B member 11 Protein disulfide-isomerase A4 HSP90B1 protein C21H28N7O14P2 NAD 664.11694 Sulfotransferase 1A3/1A4 78 kDa glucose-regulated protein Q06520 UniProt C00015 KEGG Compound CHEBI:32636 ChEBI 50700-49-7 CAS Cytochrome P450 2E1 C21H29N7O14P2 NADH 665.12476 Glutathione S-transferase P 1.0 10066-90-7 CAS CHEBI:32635 ChEBI 5957 PubChem-compound BiologicalState53 Homo sapiens, Liver, Hepatocyte, Cell Membrane Multidrug resistance-associated protein 5 Hepatocyte UDP-glucuronosyltransferase 1-1 C06804 KEGG Compound Stromal cell-derived factor 2-like protein 1 1.0 Endoplasmic reticulum resident protein 29 Protein disulfide-isomerase A4 Acetaminophen cystein Protein disulfide-isomerase A6 Peptidyl-prolyl cis-trans isomerase B HYOU1 protein 56-65-5 CAS 53-84-9 CAS Protein disulfide-isomerase A2 Protein disulfide-isomerase A2 78 kDa glucose-regulated protein P08183 UniProt 83939 PubChem-compound Reaction2030 false Acetaminophen + NAD → NADH + NAPQI LEFT_TO_RIGHT C10H15N5O10P2 Adenosine diphosphate 427.02942 Cytochrome P450 2A6 GO:0005737 GENE ONTOLOGY 2.5.1.18 false 2.5.1.18 Glutathione + NAPQI → Acetaminophen cystein + Water LEFT_TO_RIGHT Multidrug resistance-associated protein 4 482-67-7 CAS HYOU1 protein 70-18-8 CAS CHEBI:17985 ChEBI OXIDIZED-GLUTATHIONE BioCyc DnaJ homolog subfamily B member 11 Endoplasmic Reticulum Membrane SMILES CC(O)=NC1=CC=C(SC[C@H](N)C(O)=O)C=C1 CL:0000000 CELL TYPE ONTOLOGY SMILES CC(=O)N=C1C=CC(=O)C=C1 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O UDP-glucuronosyltransferase 1-6 CPD-8587 BioCyc Cytochrome P450 2D6 Sulfotransferase 1A1 5682 ChemSpider UDP BioCyc CHEBI:17980 ChEBI SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:46195 ChEBI O60656 UniProt 1.0 BiologicalState31 Homo sapiens, Liver, Cell, Cytoplasm HMDB01859 HMDB Adenosine triphosphate P30040 UniProt P22309 UniProt 103-90-2 CAS HMDB60946 HMDB ReactionCatalysis1849 ACTIVATION P09211 UniProt P30711 UniProt Water Paracetamol sulfate C00167 KEGG Compound ReactionCatalysis1852 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ReactionCatalysis1851 ACTIVATION Multidrug resistance protein 1 Acetaminophen glucuronide NAPQI C00051 KEGG Compound NAD P50225 UniProt C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 P50224 UniProt Cytoplasm HMDB00538 HMDB 83997 PubChem-compound ReactionCatalysis1850 ACTIVATION Cell CHEBI:15422 ChEBI 1.0 C10H15N5O13P2S Phosphoadenosine phosphosulfate 506.98624 HMDB10316 HMDB 1.0 140102 ChemSpider Multidrug resistance-associated protein 5 C00054 KEGG Compound C00053 KEGG Compound 2.0 388299 ChemSpider 7732-18-5 CAS Multidrug resistance-associated protein 4 ReactionCatalysis1863 ACTIVATION ReactionCoupledTransport63 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis1862 ACTIVATION ReactionCoupledTransport62 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT HSP90B1 protein ReactionCoupledTransport65 false Acetaminophen glucuronide + Adenosine triphosphate + Water → Acetaminophen glucuronide + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT ReactionCatalysis1864 ACTIVATION ReactionCoupledTransport64 false Adenosine triphosphate + Paracetamol sulfate + Water → Adenosine diphosphate + Paracetamol sulfate + Phosphate LEFT_TO_RIGHT 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Paracetamol sulfate + Water → Adenosine diphosphate + Paracetamol sulfate + Phosphate LEFT_TO_RIGHT 3.6.3.44 false 3.6.3.44 Acetaminophen glucuronide + Adenosine triphosphate + Water → Acetaminophen glucuronide + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT GO:0005789 GENE ONTOLOGY Estrogen sulfotransferase 75789 ChemSpider NAPQI 16522 ChemSpider ReactionCatalysis1861 ACTIVATION ReactionCoupledTransport61 false Acetaminophen cystein + Adenosine triphosphate + Water → Acetaminophen cystein + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 BiologicalState10 Homo sapiens, Liver, Cell, Endoplasmic Reticulum Membrane Estrogen sulfotransferase Sulfotransferase 1A1 10214 PubChem-compound 16110-10-4 CAS CHEBI:16761 ChEBI SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O 1.0 UDP-glucuronosyltransferase 1-9 9606 TAXONOMY P10635 UniProt 962 PubChem-compound 1.0 5800 ChemSpider 58-98-0 CAS UDP-glucuronosyltransferase 1-1 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O HMDB00295 HMDB 5893 PubChem-compound HMDB02111 HMDB PAPS BioCyc 1.0 2.0 Acetaminophen Glutathione 5809 ChemSpider Glutathione S-transferase theta-1 CHEBI:15377 ChEBI Cell Membrane P05177 UniProt Multidrug resistance-associated protein 1 1.0 1.0 1.0 14265-44-2 CAS P08684 UniProt 1.0 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB00061 HMDB Adenosine 3',5'-diphosphate 1.0 111188 ChemSpider Peptidyl-prolyl cis-trans isomerase B HMDB01487 HMDB 1.0 1.0 75741 ChemSpider P05181 UniProt P11509 UniProt SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)N1C=CC(=O)NC1=O P19224 UniProt P49888 UniProt H2O Water 18.010565 Sulfotransferase 1A3/1A4 http://identifiers.org/smpdb/SMP00640 SMPDB 1906 ChemSpider 75744 ChemSpider Uridine 5'-diphosphate NADH BioCyc SMILES CC(=O)NC1=CC=C(OS(O)(=O)=O)C=C1 NAD BioCyc HMDB01134 HMDB 1061 PubChem-compound Q9UNQ0 UniProt CHEBI:17659 ChEBI Multidrug resistance protein 1 1.0 Glutathione S-transferase P 1983 PubChem-compound Q15084 UniProt P33527 UniProt P23284 UniProt Glutathione S-transferase theta-1 Adenosine diphosphate Acetaminophen cystein C14H17NO8 Acetaminophen glucuronide 327.09543 1.0 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Endoplasmic Reticulum CYP2E1 CYP1A2 CYP2D6 CYP3A4 CYP2A6 UGT1A9 UGT2B15 UGT1A1 UGT1A6 GSTP1 GSTT1 SULT1A1 SULT1E1 SULT2A1 SULT1A3 ABCC1 ABCC4 ABCC5 ABCG2 ABCB1 Acetaminophen NAD NAPQI NADH Uridine diphosphate glucuronic acid Acetaminophen glucuronide Uridine 5'-diphosphate Glutathione Acetaminophen cystein Water Phosphoadenosine phosphosulfate Paracetamol sulfate Adenosine 3',5'- diphosphate Water Adenosine triphosphate Acetaminophen cystein Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Paracetamol sulfate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Acetaminophen glucuronide