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Pathway Description
Doxepin Metabolism Pathway
Homo sapiens
Drug Metabolism Pathway
Doxepin is a tricyclic antidepressant (TCA) that can be used for treating major depressive disorder and sleep maintenance. Doxepin is metabolized by cytochrome P450 2C19, 1A2, 2C9, 3A4 to form N-desmethyldoxepin, and form (E)-2-hydroxydoxepin by solely cytochrome P450 2D6 in ER of liver.
References
Doxepin Pathway References
[PharmgKB](http://www.pharmgkb.org/pathway/PA165981686)
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