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Cytochrome P450 2B6 Cytochrome P450 2C8 Cytochrome P450 2C9 UDP- glucuronosyltransferase 1-1 UDP- glucuronosyltransferase 1-9 Cytochrome P450 3A4 Sorafenib Sorafenib metabolite M3 Sorafenib metabolite M4 Sorafenib metabolite M5 Uridine diphosphate glucuronic acid Sorafenib β-D-Glucuronide Uridine 5'-diphosphate H2O O2 Sorafenib N-oxide H2O2 Sorafenib metabolite M1 Sorafenib N-oxide glucuronide Heme Heme Heme Heme Endoplasmic Reticulum Membrane
Endoplasmic Reticulum CYP2B6 CYP2C8 CYP2C9 UGT1A1 UGT1A9 CYP3A4 Sorafenib Sorafenib metabolite M3 Sorafenib metabolite M4 Sorafenib metabolite M5 Uridine diphosphate glucuronic acid Sorafenib β-D-Glucuronide Uridine 5'-diphosphate Water Oxygen Sorafenib N-oxide Hydrogen peroxide Sorafenib metabolite M1 Sorafenib N-oxide glucuronide
CYP2B6 CYP2C8 CYP2C9 UGT1A1 UGT1A9 CYP3A4 Sfib smM3 smM4 smM5 UDPGlcA SfbBGlu UDP H2O O2 safNo H2O2 SmM1 safNog Heme Heme Heme Heme Endoplasmic Reticulum Membrane
Endoplasmic Reticulum CYP2B6 CYP2C8 CYP2C9 UGT1A1 UGT1A9 CYP3A4 Sfib smM3 smM4 smM5 UDPGlcA SfbBGlu UDP H2O O2 safNo H2O2 SmM1 safNog