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Pathway Description
Arbutamine Action Pathway
Homo sapiens
Drug Action Pathway
Arbutamine is a synthetic catecholamine used to initiate a cardiac stress response to mimic exercise to detect coronary artery disease. Arbutamine has nonselective beta and weak alpha-1-adrenergic activity which causes increased chronotropic activity (increase in heart rate) and inotropic activity (increase myocardial contractility). These effects mimic the cardiovascular effects of exercise. For patients with cardiovascular artery disease, arbutamine can induce myocardial ischemia. Arbutamine is delivered via a computer controlled closed-loop system. The infusion of arbutamine is based off the heart rate feedback. The system monitors heart rate and blood pressure throughout infusion with alarms for physiological changes or problems.
References
Arbutamine Pathway References
Pierard LA, Melon PG, Lancellotti P, De Landsheere CM, Degueldre C, Kulbertus HE: Identification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography. Acta Cardiol. 2001 Dec;56(6):387-94. doi: 10.2143/AC.56.6.2005703.
Pubmed: 11791807
Crouse L: Advances in Pharmacological Cardiac Stress Testing: Arbutamine Closed-Loop Feedback System. Echocardiography. 1998 May;15(4):393-400.
Pubmed: 11175055
Bach DS, Armstrong WF: Adequacy of low-stress arbutamine to provoke myocardial ischemia during echocardiography. International Arbutamine Study Group. Am J Cardiol. 1995 Aug 1;76(4):259-62.
Pubmed: 7618620
Dennis CA, Pool PE, Perrins EJ, Mohiuddin SM, Sklar J, Kostuk WJ, Muller DW, Starling MR: Stress testing with closed-loop arbutamine as an alternative to exercise. The International Arbutamine Study Group. J Am Coll Cardiol. 1995 Nov 1;26(5):1151-8.
Pubmed: 7594026
Striated Muscle Contraction References
Cooke R: The sliding filament model: 1972-2004. J Gen Physiol. 2004 Jun;123(6):643-56. doi: 10.1085/jgp.200409089.
Pubmed: 15173218
Szent-Gyorgyi A: The mechanism of muscle contraction. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3343-4.
Pubmed: 4610574
Kuo IY, Ehrlich BE: Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015 Feb 2;7(2):a006023. doi: 10.1101/cshperspect.a006023.
Pubmed: 25646377
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