Amiodarone, trade name Cordarone and Nexterone, is an antianginal and a class III antiarrhythmic drug prescribed to treat irregular heart rhythms. The drug inhibits Na,K-activated myocardial adenosine triphosphatase, calcium and potassium channels and beta adrenergic receptors causing an increase in ventricular and atrial muscle action duration. This inhibition causes prevents repolarization of the cells causing heart rate to decrease and vascular resistance to decrease. Amiodarone exerts its antiarrhythmic effect by prolonging the duration of myocardial cell-action potentials. Amiodarone is unique to other class III antiarrhythmic drugs due to its effect on beta adrenergic receptors, calcium channels and sodium channels.
References
Amiodarone Pathway References
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