PathWhiz

Pathway Description

Abacavir Action Pathway

Homo sapiens

Drug Action Pathway

Abacavir (also known as Ziagen or Epzicom) is an antiviral agent that is used for treating HIV/AID. Cellular enzyme converts abacavir to its activate metabolite, carbovir triphosphate, for inhibiting HIV-1 reverse transcriptase (RT) by competing with dGTP, which is the natural substrate of RT. Without HIV-1 reverse transcriptase, complementary DNA (cDNA) could not be generated; therefore, viral DNA couldn't be completed.

References

Abacavir Pathway References

Falcinelli E, Francisci D, Belfiori B, Petito E, Guglielmini G, Malincarne L, Mezzasoma A, Sebastiano M, Conti V, Giannini S, Bonora S, Baldelli F, Gresele P: In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013 Aug;110(2):349-57. doi: 10.1160/TH12-07-0504. Epub 2013 May 23.

Pubmed: 23703656

Viral Transcription Inhibition References

Highlighted elements will appear in red.

Highlight Compounds

	Abacavir
	Adenosine monophosphate
	Adenosine triphosphate
	Carbovir Triphosphate
	Pyrophosphate

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