Bifunctional
protein BirA
Biotin
synthesis
protein BioC
3-oxoacyl-
[acyl- carrier-
protein]
synthase 1
3-oxoacyl-
[acyl- carrier-
protein]
reductase
(3R)-
hydroxymyristoyl-
[acyl- carrier-
protein]
dehydratase
Enoyl-[acyl-
carrier-
protein]
reductase
[NADH]
3-oxoacyl-
[acyl- carrier-
protein]
synthase 2
3-oxoacyl-
[acyl- carrier-
protein]
reductase
(3R)-
hydroxymyristoyl-
[acyl- carrier-
protein]
dehydratase
Enoyl-[acyl-
carrier-
protein]
reductase
[NADH]
Carboxylesterase
BioH
8-amino-7-
oxononanoate
synthase
Adenosylmethionine-
8-amino-7-
oxononanoate
aminotransferase
Dethiobiotin
synthetase
Biotin synthase
Bifunctional
protein BirA
ATP
diphosphate
Biotinyl-5'-AMP
S-
Adenosylmethionine
S-
Adenosylhomocysteine
H+
CO2
NADPH
H+
NADP
H2O
NADP
NADPH
H+
CO2
NADPH
H+
NADP
H2O
NADPH
H+
NADP
H2O
Methanol
L-Alanine
CO2
8-amino-7-
oxononanoic
acid
S-
Adenosylmethionine
S-Adenosyl-4-
methylthio-2-
oxobutanoate
7,8-
Diaminononanoate
ATP
CO2
Dethiobiotin
ADP
Pi
S-
Adenosylmethionine
H+
a sulfurated
[sulfur
carrier]
Biotin
L-Methionine
5'-
Deoxyadenosine
AMP
a malonyl-[acp]
a malonyl-[acp]
methyl ester
a malonyl-[acp]
a holo-[acyl-
carrier
protein]
3-
Ketoglutaryl-
[acp] methyl
ester
a 3R-
hydroxyglutaryl-
[acp] methyl
ester
Enoylglutaryl-
[acp] methyl
ester
Glutaryl-[acp]
methyl ester
a malonyl-[acp]
a holo-[acyl-
carrier
protein]
3-
Ketopimeloyl-
[acp] methyl
ester
3-
Hydroxypimeloyl-
[acp] methyl
ester
an
enoylpimeloyl-
[acp] methyl
ester
a
pimeloyl-[acp]
methyl ester
a
pimeloyl-[acp]
a holo-[acyl-
carrier
protein]
apo-
[carboxylase]
Biotin-Carboxyl
Carrying
Protein
Fatty Acid
Biosynthesis