Glutamate/aspartate transport system permease protein gltK
CHEBI:16015
ChEBI
6022
PubChem-compound
P04036
UniProt
439161
PubChem-compound
Diaminopimelate epimerase
937
ChemSpider
22138-53-0
CAS
1.0
direct_interaction
Methionine Biosynthesis
SubPathway
50
ChemSpider
1.0
L,L-diaminopimelate
809
ChemSpider
N-Succinyl-L,L-2,6-diaminopimelate
Glutamate/aspartate periplasmic-binding protein
ATP
BioCyc
(S)-2,3,4,5-tetrahydrodipicolinate
2.0
5747
ChemSpider
5745
ChemSpider
CHEBI:15380
ChEBI
5742
ChemSpider
C25H40N7O19P3S
Succinyl-CoA
867.1312
L-ASPARTATE
BioCyc
Glutamate/aspartate transport system permease protein gltJ
CHEBI:16474
ChEBI
P18335
UniProt
389314
ChemSpider
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
P08660
UniProt
Aerobic C4-dicarboxylate transport protein
Proton glutamate symport protein
Succinyl-diaminopimelate desuccinylase
1010
ChemSpider
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
1.0
SMP0000795
SMPDB
Glutamate/aspartate transport ATP-binding protein gltL
SMP0000794
SMPDB
4.0
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O
1.0
1.0
Hydrogen Ion
Cytosol
Dihydrodipicolinate synthase
SUC
BioCyc
Acetylornithine/succinyldiaminopimelate aminotransferase
56-87-1
CAS
1.0
C00009
KEGG Compound
C00008
KEGG Compound
C00006
KEGG Compound
Hydrogen Ion
P0ABN5
UniProt
CHEBI:18009
ChEBI
C00001
KEGG Compound
ReactionCoupledTransportCatalysis142
ACTIVATION
Aspartate-semialdehyde dehydrogenase
Glutamate/aspartate transport ATP-binding protein gltL
C00005
KEGG Compound
CHEBI:18367
ChEBI
1032
ChemSpider
NADPH
L-Aspartic acid
C00002
KEGG Compound
1031
ChemSpider
ReactionCoupledTransport108
false
Adenosine triphosphate + L-Aspartic acid + Water → Adenosine diphosphate + Hydrogen Ion + L-Aspartic acid + Phosphate
LEFT_TO_RIGHT
Anaerobic C4-dicarboxylate transporter dcuC
Anaerobic C4-dicarboxylate transporter dcuB
L-Aspartic acid
Pyruvic acid
Coenzyme A
Peptidoglycan Biosynthesis I
SubPathway
44367445
PubChem-compound
C00011
KEGG Compound
C00010
KEGG Compound
NAD(P)
BioCyc
Succinyl-diaminopimelate desuccinylase
562
TAXONOMY
P0ABP1
UniProt
H
Hydrogen Ion
1.007825
P0ABP4
UniProt
388307
ChemSpider
C00022
KEGG Compound
56-65-5
CAS
Aspartate kinase
Glutamate/aspartate periplasmic-binding protein
L-Glutamic acid
C00026
KEGG Compound
C00025
KEGG Compound
SMILES
NC(CC(=O)OP(O)(O)=O)C(O)=O
NADP
SMP0000924
SMPDB
P0AAG3
UniProt
1.0
328-50-7
CAS
HMDB0000254
HMDB
SMILES
OC(=O)CCC(O)=O
Dihydrodipicolinate synthase
HMDB0001341
HMDB
P0AFR2
UniProt
C00042
KEGG Compound
C00049
KEGG Compound
C00047
KEGG Compound
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
NC(CCC[C@H](NC(=O)CCC(O)=O)C(O)=O)C(O)=O
Anaerobic C4-dicarboxylate transporter dcuA
604-98-8
CAS
1.0
SMILES
OC(=O)CCC(=O)N[C@@H](CCCC(=O)C(O)=O)C(O)=O
HMDB0000148
HMDB
1.0
tetrahydrodipicolinate succinylase
CHEBI:18019
ChEBI
HMDB0012250
HMDB
7732-18-5
CAS
L-BETA-ASPARTYL-P
BioCyc
56-86-0
CAS
HMDB0012266
HMDB
HMDB0012267
HMDB
SMP0000834
SMPDB
P0AER3
UniProt
C10H16N5O13P3
Adenosine triphosphate
506.99576
CHEBI:57791
ChEBI
P0AER5
UniProt
4.0
1.0
CHEBI:17053
ChEBI
1.0
C04421
KEGG Compound
Glutamate/aspartate transport system permease protein gltK
Glutamate/aspartate transport system permease protein gltJ
SMILES
CC(=O)C(O)=O
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
962
PubChem-compound
5800
ChemSpider
CO2
Carbon dioxide
43.98983
C00080
KEGG Compound
Periplasmic Space
1.0
CHEBI:537519
ChEBI
HMDB0002111
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
1.0
HMDB0001022
HMDB
PW000814
PathWhiz
C6H14N2O2
L-Lysine
146.10553
14265-44-2
CAS
PYRUVATE
BioCyc
832
PubChem-compound
58-64-0
CAS
SMILES
N[C@@H](CC=O)C(O)=O
Putative sulfate transporter ychM
SMILES
[O-]C(=O)C1CCCC(=N1)C([O-])=O
SMILES
OC1CC(N=C(C1)C([O-])=O)C([O-])=O
C00091
KEGG Compound
1.0
CHEBI:57609
ChEBI
C4H7NO4
L-Aspartic acid
133.0375
HMDB0000182
HMDB
L-aspartic 4-semialdehyde
SMILES
N[C@@H](CCC[C@H](N)C(O)=O)C(O)=O
Transport453
false
L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol
LEFT_TO_RIGHT
Transport452
false
L-Aspartic acid (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol
LEFT_TO_RIGHT
SMILES
[H][C@](N)(CCC[C@@]([H])(N)C(O)=O)C(O)=O
L-Lysine
L-Aspartic acid
22833512
PubChem-compound
C04462
KEGG Compound
H2O
Water
18.010565
Proton glutamate symport protein
Aerobic C4-dicarboxylate transport protein
HMDB0000191
HMDB
Transport455
false
L-Aspartic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol
LEFT_TO_RIGHT
Transport454
false
L-Aspartic acid (→), Succinic acid (←) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol
LEFT_TO_RIGHT
HMDB0059597
HMDB
Dihydrodipicolinate reductase
Acetylornithine/succinyldiaminopimelate aminotransferase
Carbon dioxide
56-84-8
CAS
1.0
4.0
P0A830
UniProt
PW000906
PathWhiz
SubPathwayInteraction109786
SubPathway109786Reaction
SubPathwayReaction
Adenosine diphosphate
N-succinyldiaminopimelate aminotransferase
1.0
30572
ChemSpider
17215925
ChemSpider
4-hydroxy-tetrahydrodipicolinate reductase
C7H14N2O4
L,L-diaminopimelate
190.09535
C7H14N2O4
meso-diaminopimelate
190.09535
SubPathwayInteraction80106
SubPathway80106Reaction
SubPathwayReaction
SubPathwayInteraction80105
SubPathway80105Reaction
SubPathwayReaction
dicarboxylate transporter
SMILES
O
2.0
HMDB0000538
HMDB
1.0
5962
PubChem-compound
1.0
25202447
PubChem-compound
6816
PubChem-compound
51
PubChem-compound
diaminopimelate decarboxylase
Succinic acid
ADP
BioCyc
C3H4O3
Pyruvic acid
88.016045
Aspartate-semialdehyde dehydrogenase
53-59-8
CAS
N-succinyl-L-diaminopimelate desuccinylase
1038
PubChem-compound
glutamate / aspartate ABC transporter
LYS
BioCyc
GO:0005829
GENE ONTOLOGY
274
ChemSpider
C5H6O5
Oxoglutaric acid
146.02153
P0A6K1
UniProt
2.0
P0A9Q9
UniProt
O4P
Phosphate
94.95342
GO:0070258
GENE ONTOLOGY
C21H30N7O17P3
NADPH
745.0911
P0A6L2
UniProt
C21H29N7O17P3
NADP
744.08325
4-hydroxy-tetrahydrodipicolinate synthase
NADPH
BioCyc
Diaminopimelate decarboxylase
Lysine-sensitive aspartokinase 3
HMDB0000208
HMDB
L-aspartic 4-semialdehyde
SubPathwayInput
HMDB0001423
HMDB
SMILES
[O-]P([O-])([O-])=O
HMDB0000217
HMDB
SMILES
OC(=O)CCC(=O)C(O)=O
124-38-9
CAS
CHEBI:30915
ChEBI
Hydrogen Ion
L-Lysine
SubPathwayInput
PW000772
PathWhiz
PW000771
PathWhiz
HMDB0001429
HMDB
1.0
Inner Membrane
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
ReactionCatalysis2500
ACTIVATION
HMDB0000221
HMDB
1.0
C03082
KEGG Compound
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
1.0
GLT
BioCyc
Anaerobic C4-dicarboxylate transporter dcuA
Succinyl-CoA
53-57-6
CAS
1.0
CHEBI:15741
ChEBI
Oxoglutaric acid
1.0
SMILES
O=C=O
1110
PubChem-compound
P0AED7
UniProt
5957
PubChem-compound
GO:0005620
GENE ONTOLOGY
C4H6O4
Succinic acid
118.02661
CHEBI:67139
ChEBI
meso-diaminopimelate
2.0
TransportCatalysis390
ACTIVATION
Dihydrodipicolinate reductase
CHEBI:16845
ChEBI
SMILES
NCCCC[C@H](N)C(O)=O
C4H7NO3
L-aspartic 4-semialdehyde
117.042595
C7H7NO5
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
185.03352
C7H7NO4
(S)-2,3,4,5-tetrahydrodipicolinate
169.0386
HMDB0000243
HMDB
Adenosine triphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
SMILES
N[C@@H](CC(O)=O)C(O)=O
C11H18N2O7
N-Succinyl-L,L-2,6-diaminopimelate
290.1114
C11H15NO8
N-Succinyl-2-amino-6-ketopimelate
289.07977
TransportCatalysis389
ACTIVATION
TransportCatalysis388
ACTIVATION
TransportCatalysis387
ACTIVATION
1.0
Adenosine triphosphate
Diaminopimelate epimerase
CPD-8587
BioCyc
diaminopimelate epimerase
2.0
Putative sulfate transporter ychM
CHEBI:1146900
ChEBI
ReactionCatalysis2493
ACTIVATION
ReactionCatalysis2492
ACTIVATION
ReactionCatalysis2495
ACTIVATION
ReactionCatalysis2494
ACTIVATION
ReactionCatalysis2497
ACTIVATION
ReactionCatalysis2496
ACTIVATION
ReactionCatalysis2499
ACTIVATION
Lysine Degradation I
SubPathway
Lysine Biosynthesis
ReactionCatalysis2498
ACTIVATION
Phosphate
P37902
UniProt
CO-A
BioCyc
1.0
1.0
5675
ChemSpider
1078
ChemSpider
Interaction988
L-Lysine inhibits Aspartate kinase
Interaction987
L-Lysine inhibits 4-hydroxy-tetrahydrodipicolinate synthase
C21H36N7O16P3S
Coenzyme A
767.11523
Adenosine diphosphate
2.0
aspartate semialdehyde dehydrogenase
Water
CHEBI:15422
ChEBI
1.17.1.8
false
1.17.1.8
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + NADPH → (S)-2,3,4,5-tetrahydrodipicolinate + NADP + Water
LEFT_TO_RIGHT
6557
ChemSpider
2.3.1.117
false
2.3.1.117
(S)-2,3,4,5-tetrahydrodipicolinate + Succinyl-CoA + Water → Coenzyme A + N-Succinyl-2-amino-6-ketopimelate
LEFT_TO_RIGHT
Escherichia coli
Anaerobic C4-dicarboxylate transporter dcuC
2.0
Anaerobic C4-dicarboxylate transporter dcuB
1.0
1.0
127-17-3
CAS
1.2.1.11
false
1.2.1.11
Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-aspartic 4-semialdehyde + NADP + Phosphate
LEFT_TO_RIGHT
4.3.3.7
false
4.3.3.7
L-aspartic 4-semialdehyde + Pyruvic acid → (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + Hydrogen Ion + Water
LEFT_TO_RIGHT
2.7.2.4
false
2.7.2.4
Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate
LEFT_TO_RIGHT
Water
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
CHEBI:16526
ChEBI
1.0
CHEBI:16761
ChEBI
CHEBI:35266
ChEBI
P21345
UniProt
Succinic acid
1.0
26605-36-7
CAS
2-KETOGLUTARATE
BioCyc
440349
PubChem-compound
110-15-6
CAS
N-SUCCINYL-2-AMINO-6-KETOPIMELATE
BioCyc
1.0
CHEBI:32816
ChEBI
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
P0A9D8
UniProt
Phosphate
Reaction2530
false
L-Glutamic acid + N-Succinyl-2-amino-6-ketopimelate → N-Succinyl-L,L-2,6-diaminopimelate + Oxoglutaric acid
LEFT_TO_RIGHT
C4H8NO7P
L-Aspartyl-4-phosphate
213.00385
280
PubChem-compound
4.0
4.1.1.20
false
4.1.1.20
Hydrogen Ion + meso-diaminopimelate → Carbon dioxide + L-Lysine
LEFT_TO_RIGHT
3.5.1.18
false
3.5.1.18
N-Succinyl-L,L-2,6-diaminopimelate + Water → L,L-diaminopimelate + Succinic acid
LEFT_TO_RIGHT
5.1.1.7
false
5.1.1.7
L,L-diaminopimelate → meso-diaminopimelate
LEFT_TO_RIGHT
1.0
Lysine-sensitive aspartokinase 3
3-METHYLBENZYLSUCCINYL-COA
BioCyc
1060
PubChem-compound
N-SUCCINYLLL-2-6-DIAMINOPIMELATE
BioCyc
1061
PubChem-compound
meso-diaminopimelate
SubPathwayInput
Hydrogen Ion
L-Aspartyl-4-phosphate
Diaminopimelate decarboxylase
HMDB0001967
HMDB
N-Succinyl-2-amino-6-ketopimelate
1.0
1.0
1.0
P00861
UniProt
85-61-0
CAS