CHEBI:16015
ChEBI
C02739
KEGG Compound
C04916
KEGG Compound
1.0
30572
ChemSpider
Histidinol dehydrogenase
Histidine biosynthesis bifunctional protein hisIE
937
ChemSpider
C9H15N4O8P
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
338.06274
ATP phosphoribosyltransferase
144886
ChemSpider
CHEBI:16255
ChEBI
1012
PubChem-compound
NADH
direct_interaction
439153
PubChem-compound
SMILES
O
Histidine Biosynthesis
Pyrophosphate
50
ChemSpider
1.0
1.0
CHEBI:15971
ChEBI
P60664
UniProt
NAD
5961
PubChem-compound
C4H6N4O
5-Aminoimidazole-4-carboxamide
126.05416
CHEBI:17111
ChEBI
histidinal dehydrogenase / histidinol dehydrogenase
histidinol-phosphate aminotransferase
1.0
SMILES
OC1=CC(Cl)=CC=C1C1=CC=CC=C1
99979-59-6
CAS
51
PubChem-compound
imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase
4836-52-6
CAS
559142
ChemSpider
1009
PubChem-compound
imidazole glycerol phosphate synthase
CHEBI:15846
ChEBI
P60757
UniProt
9679
PubChem-compound
5746
ChemSpider
1.0
6038
ChemSpider
5-Aminoimidazole-4-carboxamide
1038
PubChem-compound
CHEBI:2030
ChEBI
7540-64-9
CAS
C5H6O5
Oxoglutaric acid
146.02153
CHEBI:16908
ChEBI
CPD-3762
BioCyc
6274
PubChem-compound
30776608
ChemSpider
O4P
Phosphate
94.95342
SMILES
N[C@H](CO)CC1=CN=CN1
1010
ChemSpider
30776607
ChemSpider
SMILES
O[C@H](COP(O)(O)=O)[C@@H](O)C1=CNC=N1
PPI
BioCyc
165271
PubChem-compound
C00119
KEGG Compound
Hydrogen Ion
C5H10N2O3
L-Glutamine
146.06914
C15H23N5O14P2
Phosphoribosyl-AMP
559.07166
HMDB0000208
HMDB
C15H26N5O20P4
Phosphoribosyl-ATP
720.01215
Imidazole glycerol phosphate synthase subunit hisF
71-00-1
CAS
1.0
Imidazole glycerol phosphate synthase subunit hisH
C15H25N5O15P2
Phosphoribulosylformimino-AICAR-P
577.0822
C15H25N5O15P2
PhosphoribosylformiminoAICAR-phosphate
577.0822
58-68-4
CAS
L-Glutamic acid
C5H13O14P3
Phosphoribosyl pyrophosphate
389.9518
SMILES
[O-]P([O-])([O-])=O
SMILES
OC(=O)CCC(=O)C(O)=O
1.0
CHEBI:30915
ChEBI
C00009
KEGG Compound
1.0
C00001
KEGG Compound
HMDB0001429
HMDB
PHOSPHORIBOSYL-FORMIMINO-AICAR-P
BioCyc
CHEBI:18361
ChEBI
CHEBI:18367
ChEBI
C00004
KEGG Compound
1032
ChemSpider
C00003
KEGG Compound
792
PubChem-compound
GLN
BioCyc
C04051
KEGG Compound
1.0
GLT
BioCyc
1.0
PRPP Biosynthesis
SubPathway
C21H28N7O14P2
NAD
664.11694
7339
PubChem-compound
HMDB0000902
HMDB
C00135
KEGG Compound
C00013
KEGG Compound
O7P2
Pyrophosphate
173.91193
C21H29N7O14P2
NADH
665.12476
HMDB0012208
HMDB
P10371
UniProt
SMILES
OP(O)(=O)OCC(=O)CC1=CNC=N1
SMILES
NC(CC1=CNC=N1)C=O
562
TAXONOMY
Phosphoribosyl pyrophosphate
SubPathwayOutput
H
Hydrogen Ion
1.007825
HMDB0003192
HMDB
Phosphoribulosylformimino-AICAR-P
L-Glutamine
Phosphoribosyl-AMP
SMILES
N[C@@H](CC1=CN=CN1)C(O)=O
PhosphoribosylformiminoAICAR-phosphate
53-84-9
CAS
C00026
KEGG Compound
2.0
Phosphoribosyl-ATP
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C00025
KEGG Compound
2.0
PHOSPHORIBOSYL-AMP
BioCyc
CHEBI:17805
ChEBI
HMDB0012234
HMDB
HMDB0012236
HMDB
1.0
2.4.2.-
false
2.4.2.-
L-Glutamine + Phosphoribulosylformimino-AICAR-P → 5-Aminoimidazole-4-carboxamide + D-Erythro-imidazole-glycerol-phosphate + Hydrogen Ion + L-Glutamic acid
LEFT_TO_RIGHT
CPD-8587
BioCyc
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
SMP0000926
SMPDB
5682
ChemSpider
328-50-7
CAS
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
439795
PubChem-compound
Water
PHOSPHORIBULOSYL-FORMIMINO-AICAR-P
BioCyc
770
ChemSpider
Reaction2867
false
Phosphoribosyl-AMP + Water → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
LEFT_TO_RIGHT
5.3.1.16
false
5.3.1.16
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide → PhosphoribosylformiminoAICAR-phosphate
LEFT_TO_RIGHT
2.4.2.17
false
2.4.2.17
Hydrogen Ion + Phosphoribosyl pyrophosphate → Phosphoribosyl-ATP + Pyrophosphate
LEFT_TO_RIGHT
3.5.4.19
false
3.5.4.19
Phosphoribosyl-ATP + Water → Hydrogen Ion + Phosphoribosyl-AMP + Pyrophosphate
LEFT_TO_RIGHT
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
1.0
23784-15-8
CAS
CHEBI:16426
ChEBI
P06986
UniProt
C6H11N3O
L-Histidinol
141.09021
56-85-9
CAS
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
7062
ChemSpider
SubPathwayInteraction109681
SubPathwayReaction
SubPathway109681Reaction
1.0
D-Erythro-imidazole-glycerol-phosphate
HMDB0000148
HMDB
ReactionCatalysis2826
ACTIVATION
ATP phosphoribosyltransferase
C6H11N2O6P
D-Erythro-imidazole-glycerol-phosphate
238.03548
P06989
UniProt
P06988
UniProt
D-ERYTHRO-IMIDAZOLE-GLYCEROL-P
BioCyc
P06987
UniProt
Histidinol-phosphate aminotransferase
Histidine biosynthesis bifunctional protein hisB
ReactionCatalysis2828
ACTIVATION
P60595
UniProt
ReactionCatalysis2827
ACTIVATION
L-Histidinol
Escherichia coli
ReactionCatalysis2829
ACTIVATION
7732-18-5
CAS
388299
ChemSpider
1.0
C04896
KEGG Compound
C01267
KEGG Compound
ReactionCatalysis2831
ACTIVATION
HMDB0001487
HMDB
ReactionCatalysis2830
ACTIVATION
ReactionCatalysis2833
ACTIVATION
HMDB0003665
HMDB
ReactionCatalysis2832
ACTIVATION
ReactionCatalysis2835
ACTIVATION
ReactionCatalysis2834
ACTIVATION
56-86-0
CAS
360-97-4
CAS
1.0
HIS
BioCyc
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
775
PubChem-compound
SMP0000830
SMPDB
CHEBI:18263
ChEBI
Histidine biosynthesis bifunctional protein hisIE
SMILES
NC(=O)C1=C(N)N=CN1
C04666
KEGG Compound
C00064
KEGG Compound
Histidinol dehydrogenase
1.0
1.0
C00860
KEGG Compound
HISTIDINAL
BioCyc
3.1.3.15
false
3.1.3.15
D-Erythro-imidazole-glycerol-phosphate → Imidazole acetol-phosphate + Water
LEFT_TO_RIGHT
2.6.1.9
false
2.6.1.9
Imidazole acetol-phosphate + L-Glutamic acid → L-histidinol-phosphate + Oxoglutaric acid
LEFT_TO_RIGHT
C12H9ClO
L-histidinol-phosphate
204.0342
440431
PubChem-compound
CHEBI:6242
ChEBI
L-histidinol-phosphate
HMDB0000280
HMDB
HMDB0003431
HMDB
Reaction2874
false
Histidinal + NAD + Water → 2 Hydrogen Ion + L-Histidine + NADH
LEFT_TO_RIGHT
Reaction2872
false
L-histidinol-phosphate + Water → L-Histidinol + Phosphate
LEFT_TO_RIGHT
1.1.1.23
false
1.1.1.23
L-Histidinol + NAD → Histidinal + Hydrogen Ion + NADH
LEFT_TO_RIGHT
962
PubChem-compound
HMDB0012277
HMDB
HMDB0012278
HMDB
2.0
2-KETOGLUTARATE
BioCyc
Phosphate
1.0
5893
PubChem-compound
HMDB0012276
HMDB
9298
ChemSpider
C00080
KEGG Compound
HMDB0000177
HMDB
Oxoglutaric acid
L-HISTIDINOL-P
BioCyc
PW000810
PathWhiz
HMDB0002111
HMDB
SMILES
N[C@@H](CCC(O)=O)C(O)=O
C6H9N2O5P
Imidazole acetol-phosphate
220.0249
C6H9N3O
Histidinal
139.07455
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
14265-44-2
CAS
C6H9N3O2
L-Histidine
155.06947
CHEBI:18406
ChEBI
389372
ChemSpider
36244-87-8
CAS
1.0
Interaction2845
L-Histidine inhibits ATP phosphoribosyltransferase
53481398
PubChem-compound
1.0
2.0
644102
PubChem-compound
1.0
L-Histidine
SMILES
O[C@H](COP(=O)(O)O)[C@@H](O)C(=O)CN\C=N\C1=C(C(=O)N)N=CN1[C@H]1O[C@@H](COP(=O)(O)O)[C@H](O)[C@@H]1O
ATP phosphoribosyltransferase
SMILES
NC1=[N+](C=NC2=C1N=CN2C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O)C1OC(COP(O)(O)=O)C(O)C1O
SMILES
NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
SMILES
N[C@@H](CCC(N)=O)C(O)=O
SMILES
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)N1C=NC2=C1N=CN([C@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O)C2=N
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
SMILES
NC(=O)C1=C(\N=C\NC2OC(COP(O)(O)=O)C(O)C2O)N(C=N1)C1OC(COP(O)(O)=O)C(O)C1O
PRPP
BioCyc
754
ChemSpider
CHEBI:18050
ChEBI
H2O
Water
18.010565
SMILES
O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O
Imidazole acetol-phosphate
Histidinal
NADH
BioCyc
NAD
BioCyc
2.0
1061
PubChem-compound
HMDB0059597
HMDB
987
ChemSpider
Imidazole glycerol phosphate synthase subunit hisH
PW000909
PathWhiz
984
ChemSpider
HMDB0000641
HMDB
Imidazole glycerol phosphate synthase subunit hisF
IMIDAZOLE-ACETOL-P
BioCyc
1.0
Histidine biosynthesis bifunctional protein hisB
Histidinol-phosphate aminotransferase