SubPathwayInteraction109727
SubPathwayReaction
SubPathway109727Reaction
C00315
KEGG Compound
6022
PubChem-compound
23656-67-9
CAS
C23H38N7O17P3S
Acetyl-CoA
809.1258
1.0
937
ChemSpider
Spermidine synthase
Spermidine
5-Methylthioribose
Spermidine synthase
SMILES
O
adenosylmethionine decarboxylase
13837702
ChemSpider
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
Methionine Biosynthesis
SubPathway
HMDB0001185
HMDB
2.0
1.0
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
2.0
HMDB0000538
HMDB
ATP
BioCyc
methionine adenosyltransferase
6137
PubChem-compound
1.0
S-ADENOSYLMETHIONINAMINE
BioCyc
D-methionine-binding lipoprotein metQ
6816
PubChem-compound
124-20-9
CAS
Water
559142
ChemSpider
4.1.1.50
false
4.1.1.50
Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine
LEFT_TO_RIGHT
ADP
BioCyc
2.5.1.-
false
2.5.1.-
Putrescine + S-Adenosylmethioninamine → 5'-S-methyl-5'-thioadenosine + Hydrogen Ion + Spermidine
LEFT_TO_RIGHT
3.2.2.9
false
3.2.2.9
5'-S-methyl-5'-thioadenosine + Water → 5-Methylthioribose + Adenine
LEFT_TO_RIGHT
ReactionCatalysis5138
ACTIVATION
ReactionCatalysis5136
ACTIVATION
ReactionCatalysis5137
ACTIVATION
C15H23N6O5S
S-Adenosylmethionine
399.14505
1.0
1.0
5742
ChemSpider
1038
PubChem-compound
1.0
Spermidine N(1)-acetyltransferase
SMILES
CSCC[C@H](N)C(O)=O
GO:0005829
GENE ONTOLOGY
274
ChemSpider
D-methionine transport system permease protein metI
HMDB0001087
HMDB
PW000837
PathWhiz
Pyrophosphate
Adenosine diphosphate
S-Adenosyl-L-Methionine Biosynthesis
SMILES
CSCC1OC(C(O)C1O)N1C=NC2=C(N)N=CN=C12
Pyrophosphate
O4P
Phosphate
94.95342
485-80-3
CAS
Acetyl-CoA
P31547
UniProt
1010
ChemSpider
GO:0070258
GENE ONTOLOGY
1.0
Methionine import ATP-binding protein MetN
Adenosine triphosphate
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
N8-Acetylspermidine
HMDB0001414
HMDB
Adenine
C9H21N3O
N8-Acetylspermidine
187.16846
PPI
BioCyc
SMILES
NCCCCN
C5H5N5
Adenine
135.05449
2.3.1.57
false
2.3.1.57
Acetyl-CoA + Spermidine → Coenzyme A + Hydrogen Ion + N8-Acetylspermidine
LEFT_TO_RIGHT
ReactionCatalysis5154
ACTIVATION
L-Methionine
HMDB0002189
HMDB
CHEBI:17148
ChEBI
CHEBI:16610
ChEBI
1.0
Hydrogen Ion
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
Cytosol
1.0
1.0
L-methionine / D-methionine ABC transporter
HMDB0001423
HMDB
HMDB0000696
HMDB
S-adenosylmethionine decarboxylase proenzyme
SMILES
[O-]P([O-])([O-])=O
124-38-9
CAS
3.6.3.-
false
3.6.3.-
Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Phosphate
LEFT_TO_RIGHT
Hydrogen Ion
110264
ChemSpider
P30750
UniProt
C00009
KEGG Compound
C00008
KEGG Compound
110-60-1
CAS
4.0
SMP0000857
SMPDB
CHEBI:15414
ChEBI
Spermidine synthase
C11H15N5O3S
5'-S-methyl-5'-thioadenosine
297.08957
ADENINE
BioCyc
ReactionCoupledTransportCatalysis145
ACTIVATION
C00001
KEGG Compound
HMDB0001429
HMDB
CHEBI:18361
ChEBI
CHEBI:18367
ChEBI
Inner Membrane
1032
ChemSpider
C00002
KEGG Compound
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
SMILES
NC1=C2NC=NC2=NC=N1
123689
PubChem-compound
SMILES
CC(=O)NCCCCNCCCN
1.0
C00019
KEGG Compound
D-methionine transport system permease protein metI
ReactionCoupledTransportCatalysis159
ACTIVATION
CHEBI:15625
ChEBI
S-ADENOSYLMETHIONINE
BioCyc
C00011
KEGG Compound
SMILES
O=C=O
C00010
KEGG Compound
C03089
KEGG Compound
C00013
KEGG Compound
C00134
KEGG Compound
O7P2
Pyrophosphate
173.91193
5957
PubChem-compound
HMDB0001206
HMDB
C7H19N3
Spermidine
145.1579
ReactionCatalysis3044
ACTIVATION
439415
PubChem-compound
CHEBI:16708
ChEBI
562
TAXONOMY
H
Hydrogen Ion
1.007825
22365-13-5
CAS
C6H12O4S
5-Methylthioribose
180.04562
P09158
UniProt
Methionine import ATP-binding protein MetN
L-Methionine
1102
PubChem-compound
MET
BioCyc
56-65-5
CAS
CPD-560
BioCyc
C00147
KEGG Compound
2.0
C00024
KEGG Compound
Adenosine triphosphate
C10H15N5O10P2
Adenosine diphosphate
427.02942
1.0
ReactionCoupledTransport125
false
Adenosine triphosphate + L-Methionine + Water → Adenosine diphosphate + Hydrogen Ion + L-Methionine + Pyrophosphate
LEFT_TO_RIGHT
1.0
1.0
73-24-5
CAS
CHEBI:16895
ChEBI
C5H11NO2S
L-Methionine
149.05106
Hydrogen Ion
PUTRESCINE
BioCyc
L-methionine / D-methionine ABC transporter
Adenosine triphosphate
CPD-8587
BioCyc
CHEBI:1146900
ChEBI
Water
Outer Membrane
GO:0043165
GENE ONTOLOGY
1.0
SMILES
NCCCCNCCCN
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
HMDB0001341
HMDB
14000-31-8
CAS
Phosphate
P0AF12
UniProt
CO-A
BioCyc
1.0
SMILES
CSC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O
1.0
1071
ChemSpider
72-89-9
CAS
C01137
KEGG Compound
CPD-3462
BioCyc
S-Adenosylmethionine
S-adenosylmethionine decarboxylase proenzyme
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Coenzyme A
S-adenosylmethionine synthase
C21H36N7O16P3S
Coenzyme A
767.11523
P28635
UniProt
Putrescine
388529
ChemSpider
C4H12N2
Putrescine
88.10005
Water
5'-S-methyl-5'-thioadenosine
CHEBI:15422
ChEBI
1.0
C01029
KEGG Compound
1.0
D-methionine transport system permease protein metI
6557
ChemSpider
Escherichia coli
D-methionine-binding lipoprotein metQ
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
7732-18-5
CAS
HMDB0000034
HMDB
1.0
1.0
63-68-3
CAS
2.0
5907
ChemSpider
Water
SMP0000834
SMPDB
CHEBI:16643
ChEBI
C10H16N5O13P3
Adenosine triphosphate
506.99576
P0A7F6
UniProt
1.0
CHEBI:16526
ChEBI
CHEBI:16761
ChEBI
HMDB0001257
HMDB
S-Adenosylmethioninamine
C00073
KEGG Compound
C14H23N6O3S
S-Adenosylmethioninamine
355.15524
1.0
962
PubChem-compound
31983
ChemSpider
8.0
5800
ChemSpider
392413
ChemSpider
CO2
Carbon dioxide
43.98983
L-Methionine
SubPathwayOutput
C00080
KEGG Compound
S-adenosylmethionine synthase
2.5.1.6
false
2.5.1.6
Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
LEFT_TO_RIGHT
CHEBI:27911
ChEBI
HMDB0002111
HMDB
PW000814
PathWhiz
CHEBI:15377
ChEBI
1.0
14265-44-2
CAS
CHEBI:15378
ChEBI
SMILES
[H+]
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
S-Adenosylmethionine
1045
PubChem-compound
Spermidine N(1)-acetyltransferase
Phosphate
1.0
Methionine import ATP-binding protein MetN
1.0
280
PubChem-compound
SMILES
C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
439904
PubChem-compound
P0A817
UniProt
D-methionine-binding lipoprotein metQ
4.0
644102
PubChem-compound
444493
PubChem-compound
HMDB0000988
HMDB
spermidine acetyltransferase
ACETYL-COA
BioCyc
H2O
Water
18.010565
190
PubChem-compound
388938
ChemSpider
1061
PubChem-compound
1.0
HMDB0059597
HMDB
SPERMIDINE
BioCyc
Carbon dioxide
HMDB0001967
HMDB
1.0
CHEBI:15351
ChEBI
1.0
1.0
24762165
PubChem-compound
P0A951
UniProt
13431-24-8
CAS
185
ChemSpider
Adenosine diphosphate
85-61-0
CAS
1.0