Bifunctional
protein folC
GTP
cyclohydrolase
1
Dihydroneopterin
triphosphate
pyrophosphatase
Dihydroneopterin
aldolase
2-amino-4-
hydroxy-6-
hydroxymethyldihydropteridine
pyrophosphokinase
Dihydropteroate
synthase
Aminodeoxychorismate
lyase
Para-
aminobenzoate
synthase
component 1
Para-
aminobenzoate
synthase
glutamine
amidotransferase
component II
Dihydrofolate
reductase folM
Tetrahydrofolic
acid
Guanosine
triphosphate
Chorismate
H2O
Formic acid
H+
7,8-
dihydroneopterin
3'-triphosphate
H2O
PPi
H+
7,8-
dihydroneopterin
3'-phosphate
H2O
Pi
7,8-
Dihydroneopterin
Glycolaldehyde
6-
hydroxymethyl-
7,8-
dihydropterin
ATP
AMP
H+
(2-amino-4-
hydroxy-7,8-
dihydropteridin-
6-yl)methyl
diphosphate
p-Aminobenzoic
acid
PPi
7,8-
Dihydropteroic
acid
4-amino-4-
deoxychorismate
Pyruvic acid
H+
L-Glutamine
L-Glutamic acid
ATP
L-Glutamic acid
ADP
Pi
H+
7,8-
dihydrofolate
monoglutamate
H+
NADPH
NADP
Magnesium
Magnesium
Potassium
Magnesium
One Carbon Pool
by Folate
Purine
Nucleotides De
Novo
Biosynthesis
Chorismate
Biosynthesis
Dihydrofolate
reductase
Magnesium