CHEBI:16015
ChEBI
30572
ChemSpider
P0ABQ4
UniProt
6022
PubChem-compound
17215925
ChemSpider
SMILES
NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1
7057990
PubChem-compound
937
ChemSpider
P08192
UniProt
Chorismate
SubPathwayOutput
HMDB0012199
HMDB
GTP cyclohydrolase 1
Para-aminobenzoate synthase glutamine amidotransferase component II
SMILES
O
Pyrophosphate
C10H14N5O7P
Adenosine monophosphate
347.06308
1.0
HMDB0002275
HMDB
C00568
KEGG Compound
CHEBI:20506
ChEBI
CHEBI:16027
ChEBI
Chorismate Biosynthesis
SubPathway
C9H12N5O7P
7,8-dihydroneopterin 3'-phosphate
333.04742
HMDB0000538
HMDB
C9H12N5O13P3
7,8-dihydroneopterin 3'-triphosphate
490.96664
DIHYDROXYPHENYLGLYCOLALDEHYDE
BioCyc
ATP
BioCyc
C19H19N7O6
7,8-dihydrofolate monoglutamate
441.14078
5961
PubChem-compound
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
1.0
40480038
PubChem-compound
1.0
1.0
18714427
ChemSpider
1.0
559142
ChemSpider
Pyruvic acid
ADP
BioCyc
Dihydroneopterin triphosphate pyrophosphatase
C3H4O3
Pyruvic acid
88.016045
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
6-hydroxymethyl-7,8-dihydropterin
Tetrahydrofolic acid
SubPathwayInput
53-59-8
CAS
SubPathwayInteraction109745
SubPathway109745Reaction
SubPathwayReaction
5746
ChemSpider
1.0
4-amino-4-deoxychorismate
5742
ChemSpider
1038
PubChem-compound
953
ChemSpider
CHEBI:16474
ChEBI
Dihydrofolate reductase folM
SMILES
O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O
GO:0005829
GENE ONTOLOGY
278
ChemSpider
C19H23N7O6
Tetrahydrofolic acid
445.171
Adenosine monophosphate
25245170
PubChem-compound
1.0
SMP0001750
SMPDB
Guanosine triphosphate
SubPathwayInput
5858
ChemSpider
O4P
Phosphate
94.95342
Para-aminobenzoate synthase component 1
Bifunctional protein folC
NADPH
6830
PubChem-compound
CHEBI:17333
ChEBI
1010
ChemSpider
DIHYDRONEOPTERIN-P3
BioCyc
Aminodeoxychorismate lyase
C00101
KEGG Compound
1.0
HMDB0001412
HMDB
CHEBI:4581
ChEBI
NADP
PPI
BioCyc
C21H30N7O17P3
NADPH
745.0911
SubPathwayInteraction109742
SubPathway109742Reaction
SubPathwayReaction
SMILES
NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1
SubPathwayInteraction109744
SubPathway109744Reaction
SubPathwayReaction
C21H29N7O17P3
NADP
744.08325
THF
BioCyc
1.0
1.0
NADPH
BioCyc
C10H16N5O14P3
Guanosine triphosphate
522.99066
Hydrogen Ion
C5H10N2O3
L-Glutamine
146.06914
Cytosol
Adenosine triphosphate
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1
CHEBI:58406
ChEBI
L-Glutamic acid
SMILES
[O-]P([O-])([O-])=O
1.0
HMDB0000217
HMDB
Formic acid
C00009
KEGG Compound
C00921
KEGG Compound
C00008
KEGG Compound
C00006
KEGG Compound
1.0
CHEBI:18009
ChEBI
C00001
KEGG Compound
HMDB0001429
HMDB
Para-aminobenzoate synthase glutamine amidotransferase component II
CHEBI:18361
ChEBI
C00005
KEGG Compound
CHEBI:18367
ChEBI
141-46-8
CAS
1032
ChemSpider
135-16-0
CAS
GTP cyclohydrolase 1
C00002
KEGG Compound
1031
ChemSpider
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
Dihydroneopterin triphosphate pyrophosphatase
Glycolaldehyde
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
C2H4O2
Glycolaldehyde
60.02113
150-13-0
CAS
GLN
BioCyc
GLT
BioCyc
Dihydrofolate reductase
PW001735
PathWhiz
GTP cyclohydrolase I
53-57-6
CAS
P26281
UniProt
Purine Nucleotides De Novo Biosynthesis
SubPathway
Folate Biosynthesis
C00251
KEGG Compound
7,8-dihydroneopterin 3'-triphosphate
7,8-dihydrofolate monoglutamate
C00013
KEGG Compound
7,8-dihydroneopterin 3'-phosphate
CHEBI:17001
ChEBI
O7P2
Pyrophosphate
173.91193
4-amino-4-deoxychorismate synthase
dihydropteroate synthase
NAD(P)
BioCyc
dihydroneopterin aldolase
1.0
5957
PubChem-compound
Dihydropteroate synthase
562
TAXONOMY
Dihydroneopterin aldolase
H
Hydrogen Ion
1.007825
P0AC13
UniProt
CHEBI:15996
ChEBI
P0AC16
UniProt
C00022
KEGG Compound
L-Glutamine
56-65-5
CAS
C00020
KEGG Compound
C00025
KEGG Compound
Dihydrofolate reductase folM
Guanosine triphosphate
C00266
KEGG Compound
HMDB0000243
HMDB
Adenosine diphosphate
P00903
UniProt
C10H15N5O10P2
Adenosine diphosphate
427.02942
1.0
SMP0000925
SMPDB
Para-aminobenzoate synthase component 1
CPD-8587
BioCyc
C04874
KEGG Compound
SMP0000927
SMPDB
4.1.2.25
false
4.1.2.25
7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
LEFT_TO_RIGHT
Reaction3398
false
7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate
LEFT_TO_RIGHT
Water
3.6.1.-
false
3.6.1.-
7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate
LEFT_TO_RIGHT
AMP
BioCyc
3.5.4.16
false
3.5.4.16
Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
LEFT_TO_RIGHT
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
7,8-dihydropteroate
BioCyc
14000-31-8
CAS
HMDB0001341
HMDB
1218-98-0
CAS
756
PubChem-compound
C00044
KEGG Compound
7,8-Dihydroneopterin
C10H10O6
Chorismate
226.04774
5675
ChemSpider
56-85-9
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Dihydrofolate reductase
1.0
CHEBI:17071
ChEBI
HMDB0000148
HMDB
18971002
PubChem-compound
C14H14N6O3
7,8-Dihydropteroic acid
314.11273
1.0
11542
ChemSpider
HMDB0000142
HMDB
7,8-Dihydropteroic acid
CHEBI:15422
ChEBI
P0AFS3
UniProt
Escherichia coli
7732-18-5
CAS
1.0
C00058
KEGG Compound
Chorismate
1.0
61-19-8
CAS
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
617-12-9
CAS
CH2O2
Formic acid
46.005478
ReactionCatalysis3369
ACTIVATION
127-17-3
CAS
Dihydroneopterin aldolase
Dihydropteroate synthase
56-86-0
CAS
P28305
UniProt
ReactionCatalysis3364
ACTIVATION
FORMATE
BioCyc
10.0
ReactionCatalysis3367
ACTIVATION
ReactionCatalysis3368
ACTIVATION
ReactionCatalysis3365
ACTIVATION
ReactionCatalysis3366
ACTIVATION
C5H9NO4
L-Glutamic acid
147.05316
SMILES
NC1=NC2=C(N=C(CO)CN2)C(=O)N1
1.0
33032
PubChem-compound
SMP0000836
SMPDB
SMILES
OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O
SMILES
[H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O
C10H16N5O13P3
Adenosine triphosphate
506.99576
ReactionCatalysis3370
ACTIVATION
1.0
659
PubChem-compound
ReactionCatalysis3371
ACTIVATION
C00064
KEGG Compound
CHEBI:16761
ChEBI
P0AFC0
UniProt
8.0
p-Aminobenzoic acid
HMDB0000045
HMDB
SMILES
CC(=O)C(O)=O
C7H7NO2
p-Aminobenzoic acid
137.04768
P-AMINO-BENZOATE
BioCyc
P0A6T5
UniProt
25201779
PubChem-compound
ReactionCatalysis3372
ACTIVATION
ReactionCatalysis3373
ACTIVATION
962
PubChem-compound
CPD-9517
BioCyc
5800
ChemSpider
736
ChemSpider
Phosphate
P05041
UniProt
1.0
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C00080
KEGG Compound
CHEBI:30753
ChEBI
Tetrahydrofolic acid
CHEBI:30751
ChEBI
2.0
170
PubChem-compound
HMDB0002111
HMDB
CHEBI:32816
ChEBI
SMILES
N[C@@H](CCC(O)=O)C(O)=O
PW000816
PathWhiz
SMILES
OC=O
CHEBI:15377
ChEBI
C10H10NO5
4-amino-4-deoxychorismate
224.05644
CHEBI:15378
ChEBI
SMILES
[H+]
14265-44-2
CAS
C7H8N5O8P2
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
351.9848
C7H9N5O2
6-hydroxymethyl-7,8-dihydropterin
195.07562
PYRUVATE
BioCyc
6569
ChemSpider
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
GTP
BioCyc
SMILES
NC1=CC=C(C=C1)C(O)=O
1.0
1.0
CHEBI:57602
ChEBI
165
ChemSpider
HMDB0001392
HMDB
HMDB0001273
HMDB
644102
PubChem-compound
6083
PubChem-compound
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
639
ChemSpider
64-18-6
CAS
SMILES
N[C@@H](CCC(N)=O)C(O)=O
C9H13N5O4
7,8-Dihydroneopterin
255.09676
2134-76-1
CAS
22833512
PubChem-compound
Aminodeoxychorismate lyase
1.0
1.0
CHEBI:18050
ChEBI
Bifunctional protein folC
H2O
Water
18.010565
CHEBI:17083
ChEBI
PW000910
PathWhiz
86-01-1
CAS
HMDB0003344
HMDB
1060
PubChem-compound
1061
PubChem-compound
SMILES
NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1
HMDB0059597
HMDB
HMDB0001846
HMDB
SMILES
[H][C@@](O)(COP(O)([O-])=O)[C@@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2[O-]
12039
PubChem-compound
SMILES
[H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O
PW000908
PathWhiz
HMDB0000641
HMDB
SMILES
OCC=O
13781857
PubChem-compound
1.5.1.3
false
1.5.1.3
7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
LEFT_TO_RIGHT
6.3.2.17
false
6.3.2.17
7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate
LEFT_TO_RIGHT
2.6.1.85
false
2.6.1.85
Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid
LEFT_TO_RIGHT
4.1.3.38
false
4.1.3.38
4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid
LEFT_TO_RIGHT
2.5.1.15
false
2.5.1.15
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate
LEFT_TO_RIGHT
1.0
2.7.6.3
false
2.7.6.3
6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion
LEFT_TO_RIGHT
One Carbon Pool by Folate
SubPathway