C5H11O7P
1-Deoxy-D-xylulose 5-phosphate
214.02425
1.0
17215925
ChemSpider
6022
PubChem-compound
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
937
ChemSpider
CHEBI:16493
ChEBI
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
BiologicalState304
Bacteria
Cytidine triphosphate
SMILES
O
HMDB0000095
HMDB
PW000975
PathWhiz
CHEBI:57919
ChEBI
2.0
Pyrophosphate
1.0
6131
PubChem-compound
1.0
1.0
HMDB0000538
HMDB
ATP
BioCyc
1.0
559142
ChemSpider
Isopentenyl-diphosphate Delta-isomerase
ADP
BioCyc
53-59-8
CAS
1.0
358-72-5
CAS
1.0
5742
ChemSpider
1038
PubChem-compound
CHEBI:16474
ChEBI
GO:0005829
GENE ONTOLOGY
5.3.3.2
false
5.3.3.2
Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate
REVERSIBLE
Reaction3694
false
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Dimethylallylpyrophosphate + NADP + Water
LEFT_TO_RIGHT
1.17.1.2
false
1.17.1.2
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + NADPH → Isopentenyl pyrophosphate + NADPH + Water
LEFT_TO_RIGHT
1.17.7.1
false
1.17.7.1
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + a reduced flavodoxin → 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate + Hydrogen Ion + Water + an oxidized flavodoxin
LEFT_TO_RIGHT
4.6.1.12
false
4.6.1.12
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol → 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate + Cytidine monophosphate
LEFT_TO_RIGHT
2.7.1.148
false
2.7.1.148
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine triphosphate → 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Adenosine diphosphate + Hydrogen Ion
LEFT_TO_RIGHT
274
ChemSpider
Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis
SubPathway
PW000958
PathWhiz
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CHEBI:58483
ChEBI
709
ChemSpider
C14H23N3O14P2
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
519.06665
NADPH
C5H10O9P2
2-C-Methyl-D-erythritol-2,4-cyclodiphosphate
275.98
1-Deoxy-D-xylulose 5-phosphate
C14H22N3O17P3
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
597.0184
1010
ChemSpider
CHEBI:57823
ChEBI
NADP
PPI
BioCyc
C21H30N7O17P3
NADPH
745.0911
C21H29N7O17P3
NADP
744.08325
2.7.7.60
false
2.7.7.60
2-C-methyl-D-erythritol 4-phosphate + Cytidine triphosphate + Hydrogen Ion → 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol + Pyrophosphate
LEFT_TO_RIGHT
1.1.1.267
false
1.1.1.267
1-Deoxy-D-xylulose 5-phosphate + Hydrogen Ion + NADPH → 2-C-methyl-D-erythritol 4-phosphate + NADP
LEFT_TO_RIGHT
63-37-6
CAS
C3H7O6P
D-Glyceraldehyde 3-phosphate
169.99803
2.0
1.0
NADPH
BioCyc
Hydrogen Ion
PW000785
PathWhiz
SMILES
[H][C@@](O)(COP(O)(O)=O)[C@@](C)(O)CO
C5H12O7P2
Isopentenyl pyrophosphate
246.00583
Cytosol
C00235
KEGG Compound
CHEBI:16057
ChEBI
Adenosine triphosphate
HMDB0000217
HMDB
1.0
124-38-9
CAS
2.0
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
C00008
KEGG Compound
C00129
KEGG Compound
1158
ChemSpider
C00006
KEGG Compound
Isopentenyl-diphosphate Delta-isomerase
CHEBI:18009
ChEBI
C5H12O7P2
Dimethylallylpyrophosphate
246.00583
SMP0000974
SMPDB
C00001
KEGG Compound
CTP
BioCyc
CHEBI:18361
ChEBI
C00005
KEGG Compound
an oxidized flavodoxin
C00002
KEGG Compound
a reduced flavodoxin
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
3.0
1.0
53-57-6
CAS
an oxidized flavodoxin
a reduced flavodoxin
Glycolysis and Pyruvate Dehydrogenase
SubPathway
CHEBI:17361
ChEBI
C00011
KEGG Compound
SMILES
O=C=O
Dimethylallylpyrophosphate
SubPathwayInput
443201
PubChem-compound
C00013
KEGG Compound
O7P2
Pyrophosphate
173.91193
NAD(P)
BioCyc
Q46893
UniProt
1-deoxy-D-xylulose 5-phosphate reductoisomerase
P45568
UniProt
5957
PubChem-compound
CHEBI:128753
ChEBI
C9H16N3O14P3
Cytidine triphosphate
482.9845
562
TAXONOMY
CHEBI:17138
ChEBI
H
Hydrogen Ion
1.007825
D-Glyceraldehyde 3-phosphate
SubPathwayInput
56-65-5
CAS
Isopentenyl pyrophosphate
SubPathwayInput
Cytidine monophosphate
DEOXYXYLULOSE-5P
BioCyc
Adenosine diphosphate
HMDB0001213
HMDB
C10H15N5O10P2
Adenosine diphosphate
427.02942
SMP0000991
SMPDB
1.0
C9H14N3O8P
Cytidine monophosphate
323.05185
1.0
647
PubChem-compound
SMP0000807
SMPDB
2.0
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
Water
4-diphosphocytidyl-2-C-methylerythritol kinase
HMDB0001347
HMDB
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Reaction3713
false
D-Glyceraldehyde 3-phosphate + Hydrogen Ion → 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
LEFT_TO_RIGHT
HMDB0000250
HMDB
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
14000-31-8
CAS
HMDB0001341
HMDB
SMILES
[H][C@@]1(O)COP([O-])(=O)OP([O-])(=O)O[C@@]1(C)CO
5675
ChemSpider
SMILES
[H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@@](C)(O)CO
SMILES
[H][C@@](O)(COP(O)(=O)OP([O-])(=O)OC[C@@]1([H])O[C@@]([H])(N2C=CC(=N)N=C2[O-])[C@]([H])(O)[C@]1([H])O)[C@](C)(CO)OP([O-])([O-])=O
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
HMDB0001112
HMDB
SMILES
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
P77488
UniProt
1-deoxy-D-xylulose-5-phosphate synthase
5901
ChemSpider
CHEBI:15422
ChEBI
1.0
SMILES
[H]\C(COP([O-])(=O)OP([O-])([O-])=O)=C(\C)CO
C00055
KEGG Compound
Escherichia coli
1.0
7732-18-5
CAS
591-59-3
CAS
SMILES
CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
1.0
C00063
KEGG Compound
1-deoxyxylulose-5-phosphate synthase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
1.0
HMDB0001120
HMDB
Isopentenyl pyrophosphate
CPD-4211
BioCyc
C10H16N5O13P3
Adenosine triphosphate
506.99576
CHEBI:16526
ChEBI
1-deoxy-D-xylulose 5-phosphate reductoisomerase
CHEBI:16761
ChEBI
65-47-4
CAS
391473
ChemSpider
962
PubChem-compound
C5H9O8P2
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
258.97726
358-71-4
CAS
5800
ChemSpider
CO2
Carbon dioxide
43.98983
1.0
Secondary Metabolites: Isoprenoid Biosynthesis (Nonmevalonate Pathway)
ReactionCatalysis3668
ACTIVATION
CMP
BioCyc
C00080
KEGG Compound
ReactionCatalysis3669
ACTIVATION
ReactionCatalysis3666
ACTIVATION
ReactionCatalysis3667
ACTIVATION
SubPathwayInteraction109896
SubPathway109896Reaction
SubPathwayReaction
729
PubChem-compound
SubPathwayInteraction109895
SubPathway109895Reaction
SubPathwayReaction
SubPathwayInteraction109897
SubPathwayReaction
SubPathway109897Reaction
HMDB0002111
HMDB
ReactionCatalysis3665
ACTIVATION
CHEBI:17677
ChEBI
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
6176
PubChem-compound
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
2-C-methyl-D-erythritol 4-phosphate
Q46822
UniProt
1.0
CHEBI:16584
ChEBI
1-deoxy-D-xylulose-5-phosphate synthase
1.0
190079-18-6
CAS
280
PubChem-compound
ReactionCatalysis3671
ACTIVATION
ReactionCatalysis3672
ACTIVATION
ReactionCatalysis3670
ACTIVATION
1.0
P62617
UniProt
P62615
UniProt
2
TAXONOMY
644102
PubChem-compound
1195
PubChem-compound
5941
ChemSpider
SMILES
CC(=C)CCOP(O)(=O)OP(O)(O)=O
C5H13O7P
2-C-methyl-D-erythritol 4-phosphate
216.03989
SMILES
OC(COP(O)(O)=O)C=O
22833512
PubChem-compound
H2O
Water
18.010565
1.0
ReactionCatalysis3686
ACTIVATION
1.0
GAP
BioCyc
Dimethylallylpyrophosphate
HMDB0059597
HMDB
2.0
P62623
UniProt
C00661
KEGG Compound
Carbon dioxide
P62620
UniProt
HMDB0001967
HMDB
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
627
ChemSpider
SMILES
CC(C)=CCO[P@](O)(=O)OP(O)(O)=O
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
C11437
KEGG Compound
1-deoxy-D-xylulose 5-phosphate reductoisomerase
HMDB0000082
HMDB