1788
Pathway
Pyrimidine Ribonucleosides Degradation
Cytidine and uridine are transported through their corresponding nucleoside hydrogen symporters. Once cytidine is incorporated into the cytosol, it is deaminated through a reaction with water and a hydrogen ion through a cytidine deaminase resulting in the release of ammonium and uridine. Uridine is then lyased by a phosphate through a uridine phosphorylase resulting in the release of a uracil and an alpha-D-ribose-1-phosphate. This compound is then transformed into an isomer D-ribose 5-phosphate through an alpha-D-ribose 1,5-phosphomutase. This compound is then incorporated into the pentose phosphate pathway.
Metabolic
PW002024
Center
PathwayVisualizationContext2311
2001
1950
#000099
PathwayVisualization1772
1788
Pyrimidine Ribonucleosides Degradation
Cytidine and uridine are transported through their corresponding nucleoside hydrogen symporters. Once cytidine is incorporated into the cytosol, it is deaminated through a reaction with water and a hydrogen ion through a cytidine deaminase resulting in the release of ammonium and uridine. Uridine is then lyased by a phosphate through a uridine phosphorylase resulting in the release of a uracil and an alpha-D-ribose-1-phosphate. This compound is then transformed into an isomer D-ribose 5-phosphate through an alpha-D-ribose 1,5-phosphomutase. This compound is then incorporated into the pentose phosphate pathway.
Metabolic
3
3751
16540542
Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S: A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. doi: 10.1073/pnas.0600521103. Epub 2006 Mar 15.
1788
Pathway
3752
Neidhardt FC, Curtiss III R, Ingraham JL, Lin ECC, Low Jr KB, Magasanik B, Reznikoff WS, Riley M, Schaechter M, Umbarger HE. Escherichia coli and Salmonella, Cellular and Molecular Biology, Second Edition. American Society for Microbiology, Washington, D.C., 1996.
1788
Pathway
1
Cell
CL:0000000
5
Hepatocyte
CL:0000182
4
Cardiomyocyte
CL:0000746
3
Neuron
CL:0000540
7
Epithelial Cell
CL:0000066
2
Platelet
CL:0000233
1
Homo sapiens
9606
Eukaryote
Human
2
Bacteria
2
Prokaryote
Bacteria
3
Escherichia coli
562
Prokaryote
12
Mus musculus
10090
Eukaryote
Mouse
5
Bos taurus
9913
Eukaryote
Cattle
17
Rattus norvegicus
10116
Eukaryote
Rat
19
Schizosaccharomyces pombe
4896
Eukaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
25
Escherichia coli (strain K12)
83333
Prokaryote
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
23
Pseudomonas aeruginosa
287
Prokaryote
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
29
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
559292
Eukaryote
Baker's yeast
5
Cytoplasm
GO:0005737
6
Lysosome
GO:0005764
4
Peroxisome
GO:0005777
3
Mitochondrial Matrix
GO:0005759
2
Mitochondrion
GO:0005739
10
Cell Membrane
GO:0005886
11
Extracellular Space
GO:0005615
16
Lysosomal Lumen
GO:0043202
7
Endoplasmic Reticulum Membrane
GO:0005789
1
Cytosol
GO:0005829
18
Melanosome Membrane
GO:0033162
13
Endoplasmic Reticulum
GO:0005783
25
Golgi apparatus
GO:0005794
14
Mitochondrial Outer Membrane
GO:0005741
12
Mitochondrial Inner Membrane
GO:0005743
20
Endoplasmic Reticulum Lumen
GO:0005788
21
Synapse
GO:0045202
15
Nucleus
GO:0005634
31
Periplasmic Space
GO:0005620
35
Chloroplast
GO:0009507
36
Membrane
GO:0016020
53
Endoplasmic Reticulum Body
GO:0010168
34
Plant-Type Vacuole
GO:0000325
40
Periplasm
GO:0042597
24
Mitochondrial Intermembrane Space
GO:0005758
32
Inner Membrane
GO:0070258
19
sarcoplasmic reticulum
GO:0016529
27
Peroxisome Membrane
GO:0005778
26
Golgi apparatus membrane
GO:0000139
1
Liver
BTO:0000759
72
9
4
Adrenal Medulla
BTO:0000049
71
8
25
Intestine
BTO:0000648
28
Stomach
BTO:0001307
155
26
7
Nervous System
BTO:0001484
8
Blood Vessel
BTO:0001102
74
11
11
Heart
BTO:0000562
73
10
2
Endothelium
BTO:0000393
5
cardiocyte
BTO:0001539
8
5
1
1
PW_BS000008
9
6
1
1
PW_BS000009
5
4
1
1
PW_BS000005
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1
1
PW_BS000004
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2
1
1
PW_BS000003
14
10
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PW_BS000014
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1
2
1
PW_BS000013
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11
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PW_BS000015
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1
16
1
1
PW_BS000028
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1
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1
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PW_BS000010
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1
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25
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1
PW_BS000043
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4
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1
1
PW_BS000024
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14
1
1
PW_BS000022
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25
1
PW_BS000060
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1
1
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PW_BS000046
17
12
1
1
PW_BS000017
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1
1
1
PW_BS000029
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28
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1
1
PW_BS000070
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5
1
3
PW_BS000072
61
25
1
7
PW_BS000061
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1
20
1
1
PW_BS000036
37
7
21
1
3
PW_BS000037
93
25
20
1
1
PW_BS000093
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15
1
PW_BS000027
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1
1
PW_BS000007
97
1
5
2
1
PW_BS000097
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5
2
1
PW_BS000100
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3
PW_BS000094
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3
3
1
PW_BS000103
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11
3
PW_BS000105
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5
12
1
PW_BS000111
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6
12
1
PW_BS000113
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2
12
1
PW_BS000112
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2
3
1
PW_BS000110
123
1
7
5
1
PW_BS000123
125
13
5
1
PW_BS000125
126
6
5
1
PW_BS000126
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1
16
5
1
PW_BS000127
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13
12
1
PW_BS000130
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11
12
PW_BS000114
129
1
5
12
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PW_BS000129
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5
17
1
PW_BS000135
118
1
17
1
PW_BS000118
108
1
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PW_BS000108
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1
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10
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PW_BS000140
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5
3
1
PW_BS000101
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1
5
19
1
PW_BS000143
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5
19
1
PW_BS000146
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31
3
PW_BS000107
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1
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2
1
PW_BS000095
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1
24
1
PW_BS000147
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1
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PW_BS000151
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PW_BS000159
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PW_BS000166
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21
1
PW_BS000178
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2
21
1
PW_BS000180
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PW_BS000152
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1
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PW_BS000117
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1
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PW_BS000024
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1
18
1
PW_BS000160
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5
6
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PW_BS000024
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6
6
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PW_BS000024
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2
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PW_BS000024
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18
PW_BS000024
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7
18
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PW_BS000024
214
25
18
1
PW_BS000024
215
6
18
1
PW_BS000024
198
5
18
1
PW_BS000024
216
4
18
1
PW_BS000024
210
13
18
1
PW_BS000024
212
1
7
18
1
PW_BS000024
222
3
4
1
PW_BS000024
224
2
4
1
PW_BS000024
190
11
18
PW_BS000024
170
18
PW_BS000170
225
35
4
1
PW_BS000024
226
4
4
1
PW_BS000024
162
12
18
1
PW_BS000162
26
1
1
1
5
PW_BS000026
277
1
2
18
PW_BS000024
164
4
PW_BS000164
281
1
25
1
PW_BS000024
285
10
4
1
PW_BS000024
286
36
4
1
PW_BS000024
287
53
4
1
PW_BS000024
249
13
4
1
PW_BS000024
227
34
4
1
PW_BS000024
65
11
1
PW_BS000065
290
5
49
1
PW_BS000024
291
6
49
1
PW_BS000024
292
4
49
1
PW_BS000024
298
1
7
10
1
PW_BS000024
300
13
10
1
PW_BS000024
301
6
10
1
PW_BS000024
302
1
16
10
1
PW_BS000024
223
12
4
1
PW_BS000024
294
11
4
1
PW_BS000024
308
10
1
1
PW_BS000024
315
1
23
PW_BS000024
318
31
23
PW_BS000024
322
1
23
1
PW_BS000024
293
4
1
PW_BS000024
253
5
4
1
PW_BS000024
132
1
12
1
PW_BS000132
133
3
12
1
PW_BS000133
134
12
12
1
PW_BS000134
331
7
12
1
PW_BS000028
332
1
7
12
1
PW_BS000028
333
1
2
12
PW_BS000028
115
10
12
PW_BS000115
334
4
12
1
PW_BS000028
336
1
12
1
PW_BS000028
337
1
16
12
1
PW_BS000028
341
4
1
12
1
PW_BS000028
343
18
12
1
PW_BS000028
347
1
3
12
5
PW_BS000028
329
14
12
1
PW_BS000028
352
25
12
PW_BS000028
353
25
12
7
PW_BS000028
356
25
12
1
PW_BS000028
360
4
10
12
1
PW_BS000028
368
3
60
1
PW_BS000028
370
2
60
1
PW_BS000028
228
36
1
PW_BS000024
119
2
17
1
PW_BS000119
383
7
5
1
PW_BS000100
384
12
5
1
PW_BS000100
390
7
6
1
PW_BS000112
391
12
6
1
PW_BS000112
398
7
17
1
PW_BS000113
232
40
3
PW_BS000024
122
5
5
1
PW_BS000122
406
3
5
1
PW_BS000115
407
2
5
1
PW_BS000115
408
4
5
1
PW_BS000115
124
1
5
1
PW_BS000124
412
1
2
5
PW_BS000115
405
10
5
PW_BS000115
409
11
5
PW_BS000115
415
18
5
1
PW_BS000115
414
1
5
5
1
PW_BS000115
425
1
3
5
5
PW_BS000115
429
1
5
1
PW_BS000115
121
12
17
1
PW_BS000121
419
25
5
1
PW_BS000115
434
4
10
5
1
PW_BS000115
382
14
5
1
PW_BS000100
436
25
5
PW_BS000115
120
3
17
1
PW_BS000120
374
4
17
1
PW_BS000053
443
6
17
1
PW_BS000115
446
1
2
17
PW_BS000115
376
10
17
PW_BS000053
137
11
17
PW_BS000137
447
1
7
17
1
PW_BS000115
136
13
17
1
PW_BS000136
448
1
16
17
1
PW_BS000115
451
18
17
1
PW_BS000115
450
1
5
17
1
PW_BS000115
460
1
3
17
5
PW_BS000115
464
1
17
1
PW_BS000115
455
25
17
1
PW_BS000115
469
4
10
17
1
PW_BS000115
399
14
17
1
PW_BS000113
471
25
17
PW_BS000115
472
25
17
7
PW_BS000115
297
5
10
1
PW_BS000024
479
3
10
1
PW_BS000115
481
2
10
1
PW_BS000115
482
4
10
1
PW_BS000115
299
1
10
1
PW_BS000024
483
11
10
PW_BS000115
478
10
10
PW_BS000115
487
18
10
1
PW_BS000115
490
25
10
1
PW_BS000115
495
7
10
1
PW_BS000115
484
14
10
1
PW_BS000115
480
12
10
1
PW_BS000115
501
3
6
1
PW_BS000115
502
4
6
1
PW_BS000115
388
1
6
1
PW_BS000112
208
11
6
PW_BS000024
209
10
6
PW_BS000024
504
18
6
1
PW_BS000115
507
25
6
1
PW_BS000115
515
4
10
6
1
PW_BS000115
389
14
6
1
PW_BS000112
395
13
6
1
PW_BS000113
513
1
7
6
1
PW_BS000115
42
24
1
1
PW_BS000042
187
31
18
PW_BS000024
219
31
4
PW_BS000024
220
1
4
PW_BS000024
195
13
18
PW_BS000024
312
5
23
1
PW_BS000024
320
11
23
PW_BS000024
327
1
1
12
5
PW_BS000028
345
24
12
1
PW_BS000028
310
31
2
PW_BS000024
304
1
2
PW_BS000024
109
32
3
PW_BS000109
424
1
1
5
5
PW_BS000115
418
24
5
1
PW_BS000115
459
1
1
17
5
PW_BS000115
454
24
17
1
PW_BS000115
489
24
10
1
PW_BS000115
506
24
6
1
PW_BS000115
47
19
1
4
PW_BS000047
23
15
1
1
PW_BS000023
241
5
29
PW_BS000024
257
15
29
1
PW_BS000024
16
2
1
2
PW_BS000016
39
7
1
1
3
PW_BS000039
21
5
1
1
4
PW_BS000021
59
27
1
1
PW_BS000059
91
8
5
1
1
PW_BS000091
56
26
1
1
PW_BS000056
104
14
3
1
PW_BS000104
199
14
18
1
PW_BS000024
288
14
4
1
PW_BS000024
335
27
12
1
PW_BS000028
184
1
2
1
PW_BS000024
372
10
2
PW_BS000028
51
8
1
PW_BS000051
422
27
5
1
PW_BS000115
375
27
17
1
PW_BS000053
491
27
10
1
PW_BS000115
508
27
6
1
PW_BS000115
235
5
25
PW_BS000024
7227
Uridine 2',3'-cyclic phosphate
HMDB0011640
Uridine 2',3'-cyclic phosphate is a cyclic nucleotide. A cyclic nucleotide is any nucleotide in which the phosphate group is bonded to two of the sugar's hydroxyl groups, forming a cyclical or ring structure. Cyclic phosphates are commonly found at the 3' end of mRNAs and other small RNAs. Uridine 2',3'-cyclic phosphate is a substrate for the enzyme 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNPase, EC 3.1.4.37) which hydrolyses it to Uridine 2'-phosphate. CNPase is a unique RNase in that it only cleaves nucleoside 2',3'-cyclic phosphates and not the RNA internucleotide linkage, like other RNases such as RNase A and RNase T1.
606-02-0
C02355
439715
28637
388781
OC[C@H]1O[C@H]([C@@H]2OP(O)(=O)O[C@H]12)N1C=CC(=O)NC1=O
C9H11N2O8P
InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/t4-,6-,7-,8-/m1/s1
HWDMHJDYMFRXOX-XVFCMESISA-N
1-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
306.166
306.02530185
-1.17
3
2',3'-cyclic ump
0
-1
C02355
1-(2,3-o-phosphinico-a-d-ribofuranosyl)-2,4(1h,3h)-pyrimidinedione;1-(2,3-o-phosphinico-alpha-delta-ribofuranosyl)-2,4(1h,3h)-pyrimidinedione;2',3'-cump;Uridine 2',3'-cyclic monophosphate;Cump;Uridine 2',3'-cyclophosphate;Uridine, cyclic 2',3'-(hydrogen phosphate);Uridine 2',3'-cyclophosphoric acid;Uridine, cyclic 2',3'-(hydrogen phosphoric acid)
PW_C007227
Ur23CPh
1420
Water
HMDB0002111
Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).
7732-18-5
C00001
962
15377
937
O
H2O
InChI=1S/H2O/h1H2
XLYOFNOQVPJJNP-UHFFFAOYSA-N
water
18.0153
18.010564686
1
water
0
0
FDB013390
Dihydrogen oxide;Steam;[oh2];Acqua;Agua;Aqua;Bound water;Dihydridooxygen;Eau;H2o;Hoh;Hydrogen hydroxide;Wasser
PW_C001420
H2O
55
8
94
9
109
5
139
4
151
3
162
14
481
13
526
15
624
28
652
10
691
20
770
33
823
18
838
2
1094
31
1377
49
1465
54
1590
43
2018
24
2532
22
2678
60
2727
46
2778
17
2805
29
3143
70
3164
72
3634
61
4598
36
4727
37
4941
93
5030
27
5156
7
5195
97
5214
100
5227
94
5236
103
5297
105
5319
111
5343
113
5355
112
5402
110
5470
123
5483
125
5492
126
5507
127
5534
130
5537
114
5541
129
5591
135
5608
118
5622
108
5691
6
5759
140
5778
101
5841
143
5853
146
5877
107
5890
95
5910
147
5940
151
6032
155
6059
157
6087
161
6123
163
6133
159
6215
1
6218
166
6477
178
6507
180
6600
152
6713
117
6840
188
6888
160
7162
205
7181
207
7193
206
7211
211
7228
213
7238
214
7243
215
7295
198
7350
216
7388
210
7401
212
7467
222
7492
224
7500
190
7588
170
8201
225
8237
226
8414
162
9265
26
11850
277
11922
164
12011
281
12213
285
12250
286
12264
287
12327
249
12520
227
12632
65
12693
290
12705
291
12715
292
13007
298
13019
300
13025
301
13037
302
13261
223
13327
294
15340
308
42327
315
42695
318
43691
322
76914
293
77019
253
77102
132
77131
133
77215
134
77378
331
77397
332
77471
333
77516
115
77536
334
77628
336
77722
337
77759
341
77816
343
77982
347
78071
329
78235
352
78242
353
78270
356
79113
360
80014
368
80039
370
80591
228
80656
119
93830
383
94794
384
110557
390
110639
391
115844
398
119879
232
119915
122
119963
406
120008
407
120046
408
120113
124
120365
412
120430
405
120438
409
120606
415
120794
414
121158
425
121240
429
121351
121
121381
419
121607
434
122118
382
122384
436
122753
120
122797
374
122804
443
123012
446
123064
376
123072
137
123131
447
123142
136
123162
448
123231
451
123384
450
123730
460
123810
464
123940
455
124165
469
124670
399
124938
471
124945
472
125305
297
125353
479
125386
481
125424
482
125480
299
125682
483
125707
478
125745
487
126054
490
126238
495
126273
484
126764
480
126896
501
126963
502
127017
388
127177
208
127199
209
127227
504
127506
507
127576
515
127836
389
128082
395
128176
513
40034
Hydrogen Ion
HMDB0059597
Hydrogen ion is recommended by IUPAC as a general term for all ions of hydrogen and its isotopes. Depending on the charge of the ion, two different classes can be distinguished: positively charged ions and negatively charged ions. Under aqueous conditions found in biochemistry, hydrogen ions exist as the hydrated form hydronium, H3O+, but these are often still referred to as hydrogen ions or even protons by biochemists. [WikiPedia])
C00080
1038
15378
1010
[H+]
H
InChI=1S/p+1
GPRLSGONYQIRFK-UHFFFAOYSA-N
hydron
1.0079
1.007825032
0
hydron
1
0
H+;H(+);Hydrogen cation;Hydron;Proton
PW_C040034
H+
215
4
670
8
753
15
788
31
848
3
1116
2
1463
26
1464
54
2231
49
2780
17
4250
22
4254
42
4547
10
4576
18
4694
70
5241
103
5327
111
5353
112
5626
108
5639
107
5699
100
5720
105
5742
117
5963
147
6037
155
6070
157
6093
161
6130
159
6232
166
6483
178
6601
152
6692
101
6843
188
6910
187
7100
163
7168
205
7191
206
7453
219
7454
220
7472
222
7525
213
7532
210
7558
212
7572
160
7590
170
8195
225
8218
151
8243
226
8413
162
8420
224
9139
195
9155
249
11915
164
12015
281
12181
285
12246
286
12266
287
12521
227
13257
223
13325
294
15330
308
42329
315
42354
318
42401
322
42405
312
42454
320
76912
293
77136
133
77210
134
77372
331
77804
114
77955
132
77990
327
77991
347
78379
345
79929
130
80019
368
80387
310
80388
304
80722
119
93823
124
94823
383
110550
388
112855
94
113280
390
115537
398
115539
118
115856
336
116205
109
119973
406
120193
407
120549
122
120593
409
121170
424
121171
425
122569
418
122615
384
122687
125
122758
120
123183
135
123218
137
123742
459
123743
460
125141
454
125188
121
125273
136
125359
479
125550
481
125730
483
125736
297
125809
299
126517
495
126717
489
126766
480
126823
300
126902
501
127213
208
128308
506
128361
391
128430
395
41181
3'-UMP
HMDB0060282
3'-UMP belongs to the class of organic compounds known as ribonucleoside 3'-phosphates. These are ribonucleosides that contain a phosphate group attached to the C-3 carbon of the ribose or deoxyribose moiety. The nucleobases here are limited to purine, pyrimidine, and pyridine derivatives. 3'-UMP is soluble (in water) and an extremely strong acidic compound (based on its pKa). 3'-UMP exists in all living organisms, ranging from bacteria to humans. 3'-UMP participates in a number of enzymatic reactions. In particular, 3'-UMP can be biosynthesized from uridine 2',3'-cyclic phosphate; which is mediated by the enzyme 2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase. In addition, 3'-UMP can be converted into uridine; which is catalyzed by the enzyme 2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase.
101543
28895
[H][C@]1(CO)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])OP(O)(O)=O
C9H13N2O9P
InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
FOGRQMPFHUHIGU-XVFCMESISA-N
{[(2R,3S,4R,5R)-4-hydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid
324.1813
324.035866536
-1.31
5
disodium salt 3'-uridylic acid
0
-2
3'-ump;3'-uridinemonophosphate;3'-uridylate;3'-uridylic acid;4rsk;Uridine 3'-(dihydrogen phosphate);Uridine 3'-monophosphate;Uridine 3'-phosphate
PW_C041181
3UMP
202
Uridine
HMDB0000296
Uridine, also known as beta-uridine or 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione, is a member of the class of compounds known as pyrimidine nucleosides. Pyrimidine nucleosides are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety. More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine is soluble (in water) and a very weakly acidic compound (based on its pKa). Uridine can be synthesized from uracil. It is one of the five standard nucleosides which make up nucleic acids; the others being adenosine, thymidine, cytidine, and guanosine. The five nucleosides are commonly abbreviated to their one-letter codes U, A, T, C, and G respectively. Uridine is also a parent compound for other transformation products, including but not limited to, nikkomycin Z, 3'-(enolpyruvyl)uridine 5'-monophosphate and 5-aminomethyl-2-thiouridine. Uridine can be found in most biofluids, including urine, breast milk, cerebrospinal fluid (CSF), and blood. Within the cell, uridine is primarily located in the mitochondria, in the nucleus, and in the lysosome. It can also be found in the extracellular space. As an essential nucleoside, uridine exists in all living species, ranging from bacteria to humans. In humans, uridine is involved in several metabolic disorders, some of which include dhydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and beta-ureidopropionase deficiency. Uridine is a nucleoside consisting of uracil and D-ribose and is a component of RNA. Uridine plays a role in the glycolysis pathway of galactose. In humans there is no catabolic process to metabolize galactose. Therefore, galactose is converted to glucose and metabolized via the normal glucose metabolism pathways. More specifically, consumed galactose is converted into galactose 1-phosphate (Gal-1-P). This molecule is a substrate for the enzyme galactose-1-phosphate uridyl transferase which transfers a UDP molecule to the galactose molecule. The end result is UDP-galactose and glucose-1-phosphate. This process is continued to allow the proper glycolysis of galactose. Uridine is found in many foods (anything containing RNA) but is destroyed in the liver and gastrointestinal tract, and so no food, when consumed, has ever been reliably shown to elevate blood uridine levels. On the other hand, consumption of RNA-rich foods may lead to high levels of purines (adenine and guanosine) in blood. High levels of purines are known to increase uric acid production and may aggravate or lead to conditions such as gout.
58-96-8
C00299
6029
16704
URIDINE
5807
DB02745
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O
C9H12N2O6
InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
DRTQHJPVMGBUCF-XVFCMESISA-N
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
244.2014
244.069536126
-0.26
4
uridine
0
0
FDB007411
1-b-d-ribofuranosyl-2,4(1h,3h)-pyrimidinedione;1-b-d-ribofuranosyluracil;1-beta-delta-ribofuranosyl-2,4(1h,3h)-pyrimidinedione;1-beta-delta-ribofuranosyluracil;Uridin;B-d-ribofuranoside 2,4(1h,3h)-pyrimidinedione-1;B-uridine;Beta-uridine;Beta-delta-ribofuranoside 2,4(1h,3h)-pyrimidinedione-1;1-beta-d-ribofuranosylpyrimidine-2,4(1h,3h)-dione;1-beta-d-ribofuranosyluracil;U;Urd;1-b-d-ribofuranosylpyrimidine-2,4(1h,3h)-dione;1-β-d-ribofuranosylpyrimidine-2,4(1h,3h)-dione;1-β-d-ribofuranosyluracil;β-uridine
PW_C000202
Uridine
2738
2
6677
108
6823
107
43667
315
43771
318
78738
132
122218
124
124770
118
126381
299
127942
388
1104
Phosphate
HMDB0001429
Phosphate is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry, biogeochemistry and ecology. Phosphate (Pi) is an essential component of life. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi and at physiological (neutral) pH primarily consists of a mixture of HPO<sup>2-</sup><sub>4</sub> and H<sub>2</sub>PO<sup>-</sup><sub>4</sub> ions. phosphates are most commonly found in the form of adenosine phosphates, (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. Similar reactions exist for the other nucleoside diphosphates and triphosphates. Phosphoanhydride bonds in ADP and ATP, or other nucleoside diphosphates and triphosphates, contain high amounts of energy which give them their vital role in all living organisms. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Phosphate levels in the blood play an important role in hormone signaling and in bone homeostasis. In classical endocrine regulation, low serum phosphate induces the renal production of the seco-steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).This active metabolite of vitamin D acts to restore circulating mineral (i.e. phosphate and calcium) levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia (softening of the bones). Another complication of chronic renal failure is hyperphosphatemia (low levels of phosphate in the blood). Hyperphosphatemia (excess levels of phosphate in the blood) is a prevalent condition in kidney dialysis patients and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated to postoperative electrolyte aberrations and after parathyroidectomy. (PMID: 17581921, 11169009, 11039261, 9159312, 17625581)Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis, its most notable effect being promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumor-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans. In particular it was found that phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23.
14265-44-2
C00009
1061
18367
CPD-8587
1032
[O-]P([O-])([O-])=O
O4P
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
NBIIXXVUZAFLBC-UHFFFAOYSA-K
phosphoric acid
94.9714
94.95342
3
phosphoric acid
0
-2
DBMET00532
FDB022617
Nfb orthophosphate;O-phosphoric acid;Ortho-phosphate;Orthophosphate (po43-);Orthophosphate(3-);Phosphate;Phosphate (po43-);Phosphate anion(3-);Phosphate ion (po43-);Phosphate ion(3-);Phosphate trianion;Phosphate(3-);Phosphoric acid ion(3-);Pi;[po4](3-);Orthophosphate;Phosphate ion;Po4(3-);Phosphoric acid;Orthophosphoric acid;Phosphoric acid ion
PW_C001104
Pi
24
4
84
8
814
5
818
18
831
2
980
3
1763
14
1767
49
2500
10
2729
47
2737
46
3129
29
3166
72
3636
61
3851
23
4249
22
4475
31
5031
27
5158
7
5207
97
5216
100
5317
111
5351
112
5381
103
5447
120
5543
129
5573
133
5605
135
5625
108
5693
6
5848
143
5855
146
5911
147
5941
151
6040
155
6100
161
6294
107
6487
178
6691
101
6714
117
6842
188
6889
160
7161
205
7189
206
7212
211
7306
198
7389
210
7402
212
7436
163
7475
222
8196
225
8258
227
10118
241
10134
257
11748
132
11761
115
11773
213
11904
170
11927
164
12014
281
12728
290
13263
223
34819
17
42255
304
42350
315
42435
318
43692
322
77018
253
77194
293
77217
134
77940
336
77966
130
78048
332
78057
329
78245
353
78669
331
80022
368
89279
308
93831
383
94796
384
110558
390
110640
391
113235
94
115845
398
116206
109
119982
406
120069
122
120699
407
121057
124
121216
125
121268
429
121352
121
121409
123
121423
382
121852
405
123304
119
123621
118
123786
136
123838
464
123968
447
123981
399
124405
376
124948
472
125362
479
125446
297
125774
481
125954
299
126221
478
126594
300
126604
298
126723
484
126904
501
127413
388
127783
209
128166
395
128177
513
128315
389
22608
Ammonium
HMDB0041827
Ammonium is an important source of nitrogen for many plant species, especially those growing on hypoxic soils. However, it is also toxic to most crop species and is rarely applied as a sole nitrogen source. The ammonium (more obscurely: aminium) cation is a positively charged polyatomic cation with the chemical formula NH4+. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR4+), where one or more hydrogen atoms are replaced by organic radical groups (indicated by R).
14798-03-9
C01342
16741146
28938
218
[NH4+]
H4N
InChI=1S/H3N/h1H3/p+1
QGZKDVFQNNGYKY-UHFFFAOYSA-O
azanium
18.0385
18.034374133
1
azanium
1
1
Ammonium ion;Ammonia ion;Ammonium;Ammonium chloride;Ammonium(1+);Azanium;Nh4+;[nh4]+;[nh4](+);Nh4(+)
PW_C022608
Ammon
5751
108
5892
95
5969
100
6226
166
8273
151
8367
225
11909
170
12470
249
42627
315
116281
109
61
Cytidine
HMDB0000089
Cytidine is a nucleoside that is composed of the base cytosine linked to the five-carbon sugar D-ribose. Cytidine is a pyrimidine that besides being incorporated into nucleic acids, can serve as a substrate for the salvage pathway of pyrimidine nucleotide synthesis. It is a precursor of cytidine triphosphate (CTP) needed in the phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthetic pathways. These variations probably reflect the species differences in cytidine deaminase, the enzyme that converts cytidine to uridine in the body. The transport of cytidine into the brain's extracellular fluid, and then into neurons and glia, are essential prerequisites for cytidine to be utilized in the brain. An efficient mechanism mediating the brain uptake of circulating cytidine has not yet been demonstrated. The biosynthesis of PC, the most abundant phosphatide in the brain, via the Kennedy pathway requires phosphocholine and cytidine triphosphate (CTP), a cytidine nucleotide involved in the rate-limiting step. The enzyme that converts CTP to endogenous CDP-choline (CTP:phosphocholine cytidylyltransferase) is unsaturated at physiological brain CTP levels. APOBEC is a family of enzymes that has been discovered with the ability to deaminate cytidines on RNA or DNA. The human apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G protein (APOBEC3G, or hA3G), provides cells with an intracellular antiretroviral activity that is associated with the hypermutation of viral DNA through cytidine deamination. Indeed, hA3G belongs to a family of vertebrate proteins that contains one or two copies of a signature sequence motif unique to cytidine deaminases (CTDAs) (PMID: 16769123, 15780864, 16720547).
65-46-3
C00475
6175
17562
CYTIDINE
5940
NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
C9H13N3O5
InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1
UHDGCWIWMRVCDJ-XVFCMESISA-N
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
243.2166
243.085520541
-0.74
4
cytidine
0
0
FDB021809
1-(b-d-ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine;1-(b-delta-ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine;1-b-d-ribofuranosylcytosine;1-b-d-ribosyl-cytosine;1-beta-d-ribofuranosyl-cytosine;1-beta-d-ribofuranosylcytosine;1-beta-delta-ribofuranosyl-cytosine;1-beta-delta-ribofuranosylcytosine;1-beta-delta-ribosyl-cytosine;1beta-d-ribofuranosylcytosine;1beta-ribofuranosylcytosine;1beta-delta-ribofuranosylcytosine;4-amino-1-b-d-ribofuranosyl-2(1h)-pyrimidinone;4-amino-1-beta-delta-ribofuranosyl-2(1h)-pyrimidinone;Cytidine;Cytosine riboside;Cytosine-1b-d-ribofuranoside;Cytosine-1b-delta-ribofuranoside;Cytosine-1beta-d-ribofuranoside;Cytosine-1beta-delta-ribofuranoside;4-amino-1-beta-d-ribofuranosyl-2(1h)-pyrimidinone;4-amino-1-beta-d-ribofuranosylpyrimidin-2(1h)-one;4-amino-1beta-d-ribofuranosyl-2(1h)-pyrimidinone;Cyd;Cytidin;Zytidin;1-β-d-ribofuranosylcytosine;1b-d-ribofuranosylcytosine;1β-d-ribofuranosylcytosine;4-amino-1-β-d-ribofuranosyl-2(1h)-pyrimidinone;4-amino-1-b-d-ribofuranosylpyrimidin-2(1h)-one;4-amino-1-β-d-ribofuranosylpyrimidin-2(1h)-one;4-amino-1b-d-ribofuranosyl-2(1h)-pyrimidinone;4-amino-1β-d-ribofuranosyl-2(1h)-pyrimidinone;Cytosine-1β-d-ribofuranoside
PW_C000061
Cytdin
2735
2
6678
108
6679
107
43668
318
43669
315
78737
132
122217
124
124769
118
126379
299
127941
388
204
Uracil
HMDB0000300
Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thymine. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for many important biochemical reactions. UDP and UTP regulate CPSase II activity in animals. UDP-glucose regulates the conversion of glucose to galactose in the liver and other tissues in the process of carbohydrate metabolism. Uracil is also involved in the biosynthesis of polysaccharides and the transportation of sugars containing aldehydes.
66-22-8
C00106
1174
17568
URACIL
1141
DB03419
O=C1NC=CC(=O)N1
C4H4N2O2
InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
ISAKRJDGNUQOIC-UHFFFAOYSA-N
1,2,3,4-tetrahydropyrimidine-2,4-dione
112.0868
112.027277382
-0.63
2
uracil
0
0
FDB006426
2,4-dihydroxypyrimidine;2,4-dioxopyrimidine;2,4-pyrimidinediol;2,4-pyrimidinedione;Hybar x;Pirod;Pyrod;Uracil;Sq-8493sid51088798;Sq-6201sq-7726sid70371;Bms-205603-01uracil
PW_C000204
Uracil
538
8
2741
2
77589
111
78739
132
120451
122
122220
124
123085
135
124772
118
125695
297
126383
299
127189
205
127943
388
1146
Ribose 1-phosphate
HMDB0001489
Ribose 1-phosphate is an intermediate in the metabolism of Pyrimidine and the metabolism of Nicotinate and nicotinamide. It is a substrate for Uridine phosphorylase 2, Phosphoglucomutase, Purine nucleoside phosphorylase and Uridine phosphorylase 1. Ribose 1-phosphate can be formed from guanosine through the action of purine nucleoside phosphorylase. Ribose 1-phosphate can also act as a ribose donor in the synthesis of xanthosine as catalyzed by the same enzyme (purine nucleoside phosphorylase). The presence of guanase, which irreversibly converts guanine to xanthine, affects the overall process of guanosine transformation. As a result of this purine pathway, guanosine is converted into xanthosine, thus overcoming the lack of guanosine deaminase in mammals. The activated ribose moiety in Ribose 1-phosphate which stems from the catabolism of purine nucleosides can be transferred to uracil and, in the presence of ATP, used for the synthesis of pyrimidine nucleotides; therefore, purine nucleosides can act as ribose donors for the salvage of pyrimidine bases. (PMID: 9133638).
14075-00-4
C00620
439236
16300
RIBOSE-1P
388373
DB03101
OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O
C5H11O8P
InChI=1S/C5H11O8P/c6-1-2-3(7)4(8)5(12-2)13-14(9,10)11/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1
YXJDFQJKERBOBM-TXICZTDVSA-N
{[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}phosphonic acid
230.1098
230.01915384
-0.82
5
ribose 1-phosphate
0
-2
FDB022650
1-o-phosphono-d-ribofuranose;D-ribofuranose 1-(dihydrogen phosphate);D-ribofuranose 1-phosphate;D-ribose-1-phosphate;D-ribose-1p;Ribofuranose 1-phosphate;Ribose 1-phosphate;A-d-ribofuranose 1-(dihydrogen phosphate);A-d-ribose 1-phosphate;Alpha-d-ribofuranose 1-(dihydrogen phosphate);Alpha-d-ribofuranose 1-phosphate;Alpha-d-ribose 1-phosphate;D-ribose 1-phosphate;D-ribose 1-phosphoric acid;Ribose 1-phosphoric acid
PW_C001146
Rib-1P
1770
2
1818
8
11783
198
77175
132
78676
111
121864
122
121968
124
124417
135
124521
118
126344
299
127725
388
1191
D-Ribose 5-phosphate
HMDB0001548
D-Ribose 5-phosphate is an important intermediate metabolite in the Pentose phosphate pathway (KEGG, map00030) and in the Purine metabolism pathway (KEGG, map00230). The intracellular ribose 5-phosphate concentration is an important determinant of the rate of de novo purine synthesis. (PMID 6699001).
4300-28-1
C00117
439167
52742
RIBOSE-5P
388313
OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
C5H11O8P
InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5?/m1/s1
KTVPXOYAKDPRHY-SOOFDHNKSA-N
{[(2R,3S,4R)-3,4,5-trihydroxyoxolan-2-yl]methoxy}phosphonic acid
230.1098
230.01915384
-0.84
5
D-ribofuranose 5-phosphate
0
-2
FDB001615
D-ribose 5-phosphate;D-ribose-5-p;D-ribose-5-phosphate;D-ribose-5-phosphorate;D-ribose-5-phosphoric acid;Ribose-5-p;Ribose-5-phosphate;Ribose-5-phosphorate;Ribose-5-phosphoric acid;Ribose-5p;D-ribose 5'-phosphate;Ribose 5-phosphate;D-ribose 5'-phosphoric acid;D-ribofuranose 5-phosphoric acid;D-ribose 5-phosphoric acid;Ribose 5-phosphoric acid
PW_C001191
DRib-5P
1758
2
1838
8
11790
198
13295
225
77171
132
78680
111
121870
122
122183
124
124423
135
124735
118
126340
299
127904
388
423
Magnesium
HMDB0000547
Magnesium salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. Physiologically, it exists as an ion in the body. It is a component of both intra- and extracellular fluids and is excreted in the urine and feces. Deficiency causes irritability of the nervous system with tetany, vasodilatation, convulsions, tremors, depression, and psychotic behavior. Magnesium ion in large amounts is an ionic laxative, and magnesium sulfate (Epsom salts) is sometimes used for this purpose. So-called "milk of magnesia" is a water suspension of one of the few insoluble magnesium compounds, magnesium hydroxide; the undissolved particles give rise to its appearance and name. Milk of magnesia is a mild base, and is commonly used as an antacid.
22537-22-0
C00305
888
18420
13-HYDROXY-MAGNESIUM-PROTOPORP
865
DB01378
[Mg++]
Mg
InChI=1S/Mg/q+2
JLVVSXFLKOJNIY-UHFFFAOYSA-N
magnesium(2+) ion
24.305
23.985041898
0
magnesium(2+) ion
2
2
FDB003518
Magnesium;Magnesium ions;Magnesium ion;Magnesium, doubly charged positive ion;Magnesium, ion (mg(2+));Mg(2+);Mg2+
PW_C000423
Mg2+
86
8
227
4
268
16
476
2
727
26
811
5
819
18
883
22
936
39
983
3
992
21
1167
46
1483
49
1529
43
1764
14
2124
10
2411
59
2942
23
3126
29
3373
7
4540
31
4774
91
4869
54
4974
56
5253
104
5329
111
5356
112
5376
103
5906
147
5934
151
6038
155
6094
161
6250
166
6484
178
6594
164
6881
160
6979
199
7170
205
7194
206
7227
213
7233
211
7250
214
7310
216
7313
198
7473
222
11763
132
11843
210
12312
225
12324
249
12513
288
12581
226
12729
290
15275
285
15337
308
77137
133
77236
329
77937
336
78393
334
78417
335
78489
115
78522
331
78536
356
78574
130
80020
368
80045
184
80048
372
80623
118
80654
135
80865
15
80965
253
81841
51
93832
383
94900
27
108596
223
110559
390
115687
398
119974
406
120070
122
120247
382
120702
407
120981
408
121181
124
121265
429
121319
419
121924
125
122086
405
122408
422
122759
120
122921
399
123307
119
123546
374
123835
464
123889
455
124477
136
124637
376
124978
375
125447
297
125598
484
125669
479
125777
481
125921
482
125947
299
125973
495
126000
490
126243
478
126553
491
126753
300
127125
389
127164
501
127380
502
127407
388
127451
507
127804
209
128125
508
128347
395
5948
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
P08331
Involved in hydrolase activity. This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate.
cpdB
b4213
AP009048
3
3.1.3.6; 3.1.4.16
8873
232
7058
Nucleoside permease nupG
P0AFF4
Involved in nucleoside transmembrane transporter activity. Transports nucleosides with a high affinity. Driven by a proton motive force.
nupG
b2964
AP009048
3
8629
109
6175
Cytidine deaminase
P0ABF6
Involved in zinc ion binding. This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
cdd
b2143
AP009048
3
3.5.4.5
135966
304
10357
uridine phosphorylase
P12758
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
udp
25
2.4.2.3
8874
235
6000
Phosphopentomutase
P0A6K6
Involved in catalytic activity. Phosphotransfer between the C1 and C5 carbon atoms of pentose.
deoB
b4383
AP009048
3
5.4.2.7
8780
101
3971
2'3' cyclic nucleotide phosphodiesterase/3' nucleotidase
3
PW_P003971
10959
5948
3972
nucleoside:H+ symporter NupG
3
PW_P003972
10960
7058
3973
cytidine deaminase
3
PW_P003973
10961
6175
2
3974
uridine phosphorylase
3
PW_P003974
10962
10357
6
3638
phosphopentomutase
3
PW_P003638
10494
6000
480
423
5895
false
PW_R005895
Right
24045
7227
1
Compound
false
24046
1420
1
Compound
false
24047
40034
1
Compound
false
24048
41181
1
Compound
false
5858
3971
3.1.3.6
5896
false
PW_R005896
Right
24049
41181
1
Compound
false
24050
1420
1
Compound
false
24051
202
1
Compound
false
24052
1104
1
Compound
false
5859
3971
5898
false
PW_R005898
Right
24058
202
1
Compound
false
24059
1104
1
Compound
true
24060
204
1
Compound
false
24061
1146
1
Compound
true
5861
3974
2.4.2.3
5899
false
PW_R005899
Right
24062
1146
1
Compound
false
24063
1191
1
Compound
false
5862
3638
5897
false
PW_R005897
Right
24053
61
1
Compound
false
24054
40034
1
Compound
false
24055
1420
1
Compound
false
24056
202
1
Compound
false
24057
22608
1
Compound
false
5860
3973
3.5.4.5
488
PW_T000487
610
202
1
Compound
107
108
Right
611
40034
1
Compound
107
108
Right
420
3972
2015-09-29T11:17:04-06:00
2015-09-29T11:17:04-06:00
109
489
PW_T000489
612
61
1
Compound
107
108
Right
613
40034
1
Compound
107
108
Right
421
3972
2015-09-29T11:25:02-06:00
2015-09-29T11:25:02-06:00
109
69424
7227
3
false
295
190
10
regular
100
120
69425
1420
49
false
416
295
10
regular
78
78
69426
40034
55
false
666
291
10
regular
78
78
69427
41181
3
false
755
199
10
regular
100
100
69428
1420
49
false
856
286
10
regular
78
78
69429
202
3
false
1225
200
10
regular
100
100
69430
1104
46
false
1173
293
10
regular
44
43
69431
202
108
3
false
1226
595
10
regular
100
100
69432
40034
107
55
false
1332
301
10
regular
78
78
69433
40034
108
55
false
1331
486
10
regular
78
78
69435
40034
55
false
812
526
10
regular
78
78
69436
1420
49
false
797
699
10
regular
78
78
69437
22608
3
false
1101
500
10
regular
100
100
69441
61
107
3
false
230
595
10
regular
100
100
69442
61
108
3
false
675
595
10
regular
100
100
69443
40034
107
55
false
316
700
10
regular
78
78
69444
40034
108
55
false
581
690
10
regular
78
78
69445
1104
46
false
1332
728
10
regular
44
43
69446
204
3
false
1325
905
10
regular
100
100
69447
1146
3
false
1225
1020
10
regular
100
110
69448
1191
3
false
1225
1345
10
regular
100
110
69449
423
9
false
1225
1185
10
regular
100
25
31974
5948
232
2
false
505
214
8
subunit
regular
150
70
31975
5948
232
2
false
975
214
8
subunit
regular
150
70
31976
7058
109
76
false
1200
390
8
subunit
regular
150
70
31977
6175
6
false
926
605
8
subunit
regular
160
80
31979
7058
109
76
false
400
609
8
subunit
regular
150
70
31980
10357
235
17
false
1185
812
8
subunit
regular
180
85
31981
6000
101
2
false
1200
1200
8
subunit
regular
150
70
26911
3971
1772
31656
31974
26912
3971
1772
31657
31975
26913
3972
1772
31658
31976
26914
3973
1772
31659
31977
26916
3972
1772
31661
31979
26917
3974
1772
31662
31980
26918
3638
1772
31663
31981
3680
69449
98817
Cofactor
98786
M395 250 C425 250 475 249 505 249
5
false
18
98787
M455 295 C459 241 475 249 505 249
5
false
18
98788
M705 291 C704 252 690 250 655 249
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98789
M755 249 C725 249 685 249 655 249
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98790
M855 249 C885 249 945 249 975 249
5
false
18
98791
M895 286 C898 245 945 249 975 249
5
false
18
98792
M1225 250 C1195 250 1155 249 1125 249
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98793
M1197 293.5 C1195 250.5 1155 249 1125 249
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98794
M1275 300 C1275 330 1275 360 1275 390
83
false
18
98795
M1276 595 C1276 565 1275 490 1275 460
83
false
18
true
M 153.6135217108315 13.26155629629604 L 138.66666666666666 12 L 145.0475543878525 25.575134323078345
false
98796
M1332 340 C1274 343 1275 360 1275 390
83
false
18
98797
M1331 525 C1282 524 1275 490 1275 460
83
false
18
true
M 153.6135217108315 13.26155629629604 L 138.66666666666666 12 L 145.0475543878525 25.575134323078345
false
98807
M330 645 C360 645 370 644 400 644
83
false
18
98808
M675 645 C645 645 580 644 550 644
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98809
M355 700 C355 649 370 644 400 644
83
false
18
98810
M620 690 C620 645 580 644 550 644
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
98811
M1276 695 C1276 725 1275 782 1275 812
5
false
18
98812
M1332 749.5 C1285 749.5 1275 782 1275 812
5
false
18
98813
M1325 955 C1273 954 1275 927 1275 897
5
false
18
true
M 25.946855044164835 264.9282229629627 L 11 263.6666666666667 L 17.380887721185843 277.241800989745
false
98814
M1275 1020 C1275 990 1275 927 1275 897
5
false
18
true
M 25.946855044164835 264.9282229629627 L 11 263.6666666666667 L 17.380887721185843 277.241800989745
false
98815
M1275 1130 C1275 1160 1275 1170 1275 1200
5
false
18
98816
M1275 1345 C1275 1315 1275 1300 1275 1270
5
false
18
true
M 25.946855044164835 531.5948896296294 L 11 530.3333333333334 L 17.380887721185843 543.9084676564117
false
98817
M1095 1180 L1095 1230 L1145 1180 z
10
true
18
3659965
M775 645 C805 645 896 645 926 645
5
false
18
3659966
M851 604 C849 646 896 645 926 645
5
false
18
3659967
M836 699 C838 662 896 645 926 645
5
false
18
3659968
M1226 645 C1196 645 1116 645 1086 645
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659969
M1151 600 C1150 631 1116 645 1086 645
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
20238
1772
5895
78598
69424
98786
Left
78599
69425
98787
Left
78600
69426
98788
Right
78601
69427
98789
Right
20415
5858
26911
20239
1772
5896
78602
69427
98790
Left
78603
69428
98791
Left
78604
69429
98792
Right
78605
69430
98793
Right
20416
5859
26912
20241
1772
5898
78611
69431
98811
Left
78612
69445
98812
Left
78613
69446
98813
Right
78614
69447
98814
Right
20418
5861
26917
20242
1772
5899
78615
69447
98815
Left
78616
69448
98816
Right
20419
5862
26918
797582
1772
5897
3223574
69442
3659965
Left
3223575
69435
3659966
Left
3223576
69436
3659967
Left
3223577
69431
3659968
Right
3223578
69437
3659969
Right
753243
5860
26914
905
488
1772
2181
69429
98794
Left
2182
69431
98795
Right
2183
69432
98796
Left
2184
69433
98797
Right
665
26913
420
907
489
1772
2189
69441
98807
Left
2190
69442
98808
Right
2191
69443
98809
Left
2192
69444
98810
Right
667
26916
421
186420
565
800
1.3
1.3
0
2
92
479
481
3469
M125 225 C125 175 175 125 225 125 C680 125 1270 125 1725 125 C1775 125 1825 175 1825 225 C1825 695 1825 1306 1825 1776 C1825 1826 1775 1876 1725 1876 C1270 1876 680 1876 225 1876 C175 1876 125 1826 125 1776 C125 1306 125 695 125 225
1
true
6
1700.0
1751.0
3470
M477 524 C477 474 527 424 577 424 C819 424 1133 424 1375 424 C1425 424 1475 474 1475 524 C1475 796 1475 1151 1475 1423 C1475 1473 1425 1523 1375 1523 C1133 1523 819 1523 577 1523 C527 1523 477 1473 477 1423 C477 1151 477 796 477 524
1
true
6
998.0
1099.0