1832
Pathway
Pyrimidine Deoxyribonucleosides Degradation
The degradation of deoxycytidine starts with deoxycytidine being introduced into the cytosol through either a nupG or nupC symporter.
Once inside, it can can be degrade through water,a hydrogen ion and a deoxycytidien deaminsa resultin in the release of a ammonium and a a deoxyuridine. The deoxyuridine is then degraded through a uracil phosphorylase resulting in the release of a deoxyribose 1-phosphate and a uracil.
The degradation of thymidine starts with thymidine being introduced into the cytosol through either a nupG or nupC symporter.
Thymidine is then degrades through a phosphorylase resulting in the release of a thymine and a deoxyribose 1-phosphate.
Metabolic
PW002063
Center
PathwayVisualizationContext2350
1604
2052
#000099
PathwayVisualization1816
1832
Pyrimidine Deoxyribonucleosides Degradation
The degradation of deoxycytidine starts with deoxycytidine being introduced into the cytosol through either a nupG or nupC symporter.
Once inside, it can can be degrade through water,a hydrogen ion and a deoxycytidien deaminsa resultin in the release of a ammonium and a a deoxyuridine. The deoxyuridine is then degraded through a uracil phosphorylase resulting in the release of a deoxyribose 1-phosphate and a uracil.
The degradation of thymidine starts with thymidine being introduced into the cytosol through either a nupG or nupC symporter.
Thymidine is then degrades through a phosphorylase resulting in the release of a thymine and a deoxyribose 1-phosphate.
Metabolic
3
3840
16540542
Loh KD, Gyaneshwar P, Markenscoff Papadimitriou E, Fong R, Kim KS, Parales R, Zhou Z, Inwood W, Kustu S: A previously undescribed pathway for pyrimidine catabolism. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5114-9. doi: 10.1073/pnas.0600521103. Epub 2006 Mar 15.
1832
Pathway
1
Cell
CL:0000000
4
Cardiomyocyte
CL:0000746
3
Neuron
CL:0000540
7
Epithelial Cell
CL:0000066
5
Hepatocyte
CL:0000182
12
Astrocyte
CL:0000127
1
Homo sapiens
9606
Eukaryote
Human
3
Escherichia coli
562
Prokaryote
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
23
Pseudomonas aeruginosa
287
Prokaryote
12
Mus musculus
10090
Eukaryote
Mouse
5
Bos taurus
9913
Eukaryote
Cattle
17
Rattus norvegicus
10116
Eukaryote
Rat
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
2
Bacteria
2
Prokaryote
Bacteria
19
Schizosaccharomyces pombe
4896
Eukaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
29
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
559292
Eukaryote
Baker's yeast
25
Escherichia coli (strain K12)
83333
Prokaryote
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
202
Spathaspora passalidarum
340170
Eukaryote
Spathaspora passalidarum
1
Cytosol
GO:0005829
31
Periplasmic Space
GO:0005620
3
Mitochondrial Matrix
GO:0005759
5
Cytoplasm
GO:0005737
4
Peroxisome
GO:0005777
13
Endoplasmic Reticulum
GO:0005783
2
Mitochondrion
GO:0005739
10
Cell Membrane
GO:0005886
7
Endoplasmic Reticulum Membrane
GO:0005789
19
Sarcoplasmic Reticulum
GO:0016529
15
Nucleus
GO:0005634
14
Mitochondrial Outer Membrane
GO:0005741
35
Chloroplast
GO:0009507
34
Plant-Type Vacuole
GO:0000325
12
Mitochondrial Inner Membrane
GO:0005743
32
Inner Membrane
GO:0070258
11
Extracellular Space
GO:0005615
24
Mitochondrial Intermembrane Space
GO:0005758
36
Membrane
GO:0016020
53
Endoplasmic Reticulum Body
GO:0010168
6
Lysosome
GO:0005764
16
Lysosomal Lumen
GO:0043202
18
Melanosome Membrane
GO:0033162
25
Golgi Apparatus
GO:0005794
20
Endoplasmic Reticulum Lumen
GO:0005788
21
Synapse
GO:0045202
40
Periplasm
GO:0042597
1
Liver
BTO:0000759
72
9
25
Intestine
BTO:0000648
28
Stomach
BTO:0001307
155
26
8
Blood Vessel
BTO:0001102
74
11
24
Brain
BTO:0000142
89
16
4
Adrenal Medulla
BTO:0000049
71
8
7
Nervous System
BTO:0001484
11
Heart
BTO:0000562
73
10
6
Kidney
BTO:0000671
71
8
2
1
1
1
PW_BS000002
107
31
3
PW_BS000107
108
1
3
PW_BS000108
151
1
4
1
PW_BS000151
315
1
23
PW_BS000024
318
31
23
PW_BS000024
132
1
12
1
PW_BS000132
124
1
5
1
PW_BS000124
118
1
17
1
PW_BS000118
299
1
10
1
PW_BS000024
388
1
6
1
PW_BS000112
4
3
1
1
PW_BS000004
8
5
1
1
PW_BS000008
5
4
1
1
PW_BS000005
18
13
1
1
PW_BS000018
3
2
1
1
PW_BS000003
14
10
1
PW_BS000014
49
7
1
1
PW_BS000049
10
1
7
1
1
PW_BS000010
47
19
1
4
PW_BS000047
46
1
1
4
PW_BS000046
29
1
1
1
PW_BS000029
72
5
1
3
PW_BS000072
61
25
1
7
PW_BS000061
23
15
1
1
PW_BS000023
22
14
1
1
PW_BS000022
31
1
5
1
1
PW_BS000031
27
15
1
PW_BS000027
7
1
1
PW_BS000007
97
1
5
2
1
PW_BS000097
100
5
2
1
PW_BS000100
111
5
12
1
PW_BS000111
112
2
12
1
PW_BS000112
103
3
3
1
PW_BS000103
120
3
17
1
PW_BS000120
129
1
5
12
1
PW_BS000129
133
3
12
1
PW_BS000133
135
5
17
1
PW_BS000135
6
1
3
1
PW_BS000006
143
1
5
19
1
PW_BS000143
146
5
19
1
PW_BS000146
147
1
24
1
PW_BS000147
155
3
24
1
PW_BS000155
161
3
18
1
PW_BS000161
178
3
21
1
PW_BS000178
101
5
3
1
PW_BS000101
117
1
3
1
PW_BS000117
188
1
18
PW_BS000024
160
1
18
1
PW_BS000160
205
5
6
1
PW_BS000024
206
2
6
1
PW_BS000024
211
10
18
PW_BS000024
198
5
18
1
PW_BS000024
210
13
18
1
PW_BS000024
212
1
7
18
1
PW_BS000024
163
2
18
1
PW_BS000163
222
3
4
1
PW_BS000024
225
35
4
1
PW_BS000024
227
34
4
1
PW_BS000024
241
5
29
PW_BS000024
257
15
29
1
PW_BS000024
115
10
12
PW_BS000115
213
7
18
1
PW_BS000024
170
18
PW_BS000170
164
4
PW_BS000164
281
1
25
1
PW_BS000024
290
5
49
1
PW_BS000024
223
12
4
1
PW_BS000024
17
12
1
1
PW_BS000017
304
1
2
PW_BS000024
322
1
23
1
PW_BS000024
253
5
4
1
PW_BS000024
293
4
1
PW_BS000024
134
12
12
1
PW_BS000134
336
1
12
1
PW_BS000028
130
13
12
1
PW_BS000130
332
1
7
12
1
PW_BS000028
329
14
12
1
PW_BS000028
353
25
12
7
PW_BS000028
331
7
12
1
PW_BS000028
368
3
60
1
PW_BS000028
308
10
1
1
PW_BS000024
383
7
5
1
PW_BS000100
384
12
5
1
PW_BS000100
390
7
6
1
PW_BS000112
391
12
6
1
PW_BS000112
94
3
PW_BS000094
398
7
17
1
PW_BS000113
109
32
3
PW_BS000109
406
3
5
1
PW_BS000115
122
5
5
1
PW_BS000122
407
2
5
1
PW_BS000115
125
13
5
1
PW_BS000125
429
1
5
1
PW_BS000115
121
12
17
1
PW_BS000121
123
1
7
5
1
PW_BS000123
382
14
5
1
PW_BS000100
405
10
5
PW_BS000115
119
2
17
1
PW_BS000119
136
13
17
1
PW_BS000136
464
1
17
1
PW_BS000115
447
1
7
17
1
PW_BS000115
399
14
17
1
PW_BS000113
376
10
17
PW_BS000053
472
25
17
7
PW_BS000115
479
3
10
1
PW_BS000115
297
5
10
1
PW_BS000024
481
2
10
1
PW_BS000115
478
10
10
PW_BS000115
300
13
10
1
PW_BS000024
298
1
7
10
1
PW_BS000024
484
14
10
1
PW_BS000115
501
3
6
1
PW_BS000115
209
10
6
PW_BS000024
395
13
6
1
PW_BS000113
513
1
7
6
1
PW_BS000115
389
14
6
1
PW_BS000112
294
11
4
1
PW_BS000024
15
11
1
PW_BS000015
26
1
1
1
5
PW_BS000026
54
1
3
1
5
PW_BS000054
42
24
1
1
PW_BS000042
70
28
5
1
1
PW_BS000070
105
11
3
PW_BS000105
157
2
24
1
PW_BS000157
159
24
PW_BS000159
166
1
1
PW_BS000166
152
8
4
PW_BS000152
187
31
18
PW_BS000024
219
31
4
PW_BS000024
220
1
4
PW_BS000024
226
4
4
1
PW_BS000024
162
12
18
1
PW_BS000162
224
2
4
1
PW_BS000024
195
13
18
PW_BS000024
249
13
4
1
PW_BS000024
285
10
4
1
PW_BS000024
286
36
4
1
PW_BS000024
287
53
4
1
PW_BS000024
312
5
23
1
PW_BS000024
320
11
23
PW_BS000024
114
11
12
PW_BS000114
327
1
1
12
5
PW_BS000028
347
1
3
12
5
PW_BS000028
345
24
12
1
PW_BS000028
310
31
2
PW_BS000024
409
11
5
PW_BS000115
424
1
1
5
5
PW_BS000115
425
1
3
5
5
PW_BS000115
418
24
5
1
PW_BS000115
137
11
17
PW_BS000137
459
1
1
17
5
PW_BS000115
460
1
3
17
5
PW_BS000115
454
24
17
1
PW_BS000115
483
11
10
PW_BS000115
495
7
10
1
PW_BS000115
489
24
10
1
PW_BS000115
480
12
10
1
PW_BS000115
208
11
6
PW_BS000024
506
24
6
1
PW_BS000115
882
31
202
PW_BS000552
883
1
202
1
PW_BS000552
167
31
1
PW_BS000167
168
32
1
PW_BS000168
788
24
11
1
3
PW_BS000524
597
24
1
12
PW_BS000336
185
3
2
1
PW_BS000024
9
6
1
1
PW_BS000009
13
1
2
1
PW_BS000013
28
1
16
1
1
PW_BS000028
20
4
1
1
1
PW_BS000020
33
18
1
1
PW_BS000033
43
25
1
1
PW_BS000043
24
4
10
1
1
PW_BS000024
60
25
1
PW_BS000060
36
1
20
1
1
PW_BS000036
37
7
21
1
3
PW_BS000037
93
25
20
1
1
PW_BS000093
113
6
12
1
PW_BS000113
110
2
3
1
PW_BS000110
126
6
5
1
PW_BS000126
127
1
16
5
1
PW_BS000127
140
10
3
PW_BS000140
95
1
7
2
1
PW_BS000095
1
1
PW_BS000001
180
2
21
1
PW_BS000180
207
6
6
1
PW_BS000024
214
25
18
1
PW_BS000024
215
6
18
1
PW_BS000024
216
4
18
1
PW_BS000024
190
11
18
PW_BS000024
277
1
2
18
PW_BS000024
65
11
1
PW_BS000065
291
6
49
1
PW_BS000024
292
4
49
1
PW_BS000024
301
6
10
1
PW_BS000024
302
1
16
10
1
PW_BS000024
333
1
2
12
PW_BS000028
334
4
12
1
PW_BS000028
337
1
16
12
1
PW_BS000028
341
4
1
12
1
PW_BS000028
343
18
12
1
PW_BS000028
352
25
12
PW_BS000028
356
25
12
1
PW_BS000028
360
4
10
12
1
PW_BS000028
370
2
60
1
PW_BS000028
228
36
1
PW_BS000024
232
40
3
PW_BS000024
408
4
5
1
PW_BS000115
412
1
2
5
PW_BS000115
415
18
5
1
PW_BS000115
414
1
5
5
1
PW_BS000115
419
25
5
1
PW_BS000115
434
4
10
5
1
PW_BS000115
436
25
5
PW_BS000115
374
4
17
1
PW_BS000053
443
6
17
1
PW_BS000115
446
1
2
17
PW_BS000115
448
1
16
17
1
PW_BS000115
451
18
17
1
PW_BS000115
450
1
5
17
1
PW_BS000115
455
25
17
1
PW_BS000115
469
4
10
17
1
PW_BS000115
471
25
17
PW_BS000115
482
4
10
1
PW_BS000115
487
18
10
1
PW_BS000115
490
25
10
1
PW_BS000115
502
4
6
1
PW_BS000115
504
18
6
1
PW_BS000115
507
25
6
1
PW_BS000115
515
4
10
6
1
PW_BS000115
790
6
11
1
PW_BS000524
834
6
1
1
1
PW_BS000549
7
Deoxyuridine
HMDB0000012
2'-Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2'-hydroxyl group. It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies.
951-78-0
C00526
13712
16450
DEOXYURIDINE
13118
OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O
C9H12N2O5
InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
MXHRCPNRJAMMIM-SHYZEUOFSA-N
228.202
228.074621504
FDB021870
1-(2-deoxy-d-erythro-pentofuranosyl)uracil;1-(2-deoxy-beta-d-erythro-pentofuranosyl)-2,4(1h,3h)-pyrimidinedione;1-(2-deoxy-beta-d-ribofuranosyl)-2,4(1h,3h)-pyrimidinedione;1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2,4(1h,3h)-pyrimidinedione;1-(2-deoxy-beta-delta-ribofuranosyl)-2,4(1h,3h)-pyrimidinedione;1-(2-deoxy-delta-erythro-pentofuranosyl)uracil;2'-deoxyuridine;2'-desoxyuridine;Deoxyribose uracil;Desoxyuridine;Uracil deoxyriboside;Uracil desoxyuridine;2-deoxyuridine;Deoxyuridine;Du
PW_C000007
Du
2755
2
6745
107
6746
108
12751
151
43715
315
43717
318
78745
132
122231
124
124783
118
126395
299
127956
388
1104
Phosphate
HMDB0001429
Phosphate is a salt of phosphoric acid. In organic chemistry, a phosphate, or organophosphate, is an ester of phosphoric acid. Organic phosphates are important in biochemistry, biogeochemistry and ecology. Phosphate (Pi) is an essential component of life. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi and at physiological (neutral) pH primarily consists of a mixture of HPO<sup>2-</sup><sub>4</sub> and H<sub>2</sub>PO<sup>-</sup><sub>4</sub> ions. phosphates are most commonly found in the form of adenosine phosphates, (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. Similar reactions exist for the other nucleoside diphosphates and triphosphates. Phosphoanhydride bonds in ADP and ATP, or other nucleoside diphosphates and triphosphates, contain high amounts of energy which give them their vital role in all living organisms. Phosphate must be actively transported into cells against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent Pi transporters carry out this task. Remarkably, the two families transport different Pi species: whereas type II Na+/Pi cotransporters (SCL34) prefer divalent HPO4(2), type III Na+/Pi cotransporters (SLC20) transport monovalent H2PO4. The SCL34 family comprises both electrogenic and electroneutral members that are expressed in various epithelia and other polarized cells. Through regulated activity in apical membranes of the gut and kidney, they maintain body Pi homeostasis, and in salivary and mammary glands, liver, and testes they play a role in modulating the Pi content of luminal fluids. Phosphate levels in the blood play an important role in hormone signaling and in bone homeostasis. In classical endocrine regulation, low serum phosphate induces the renal production of the seco-steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).This active metabolite of vitamin D acts to restore circulating mineral (i.e. phosphate and calcium) levels by increasing absorption in the intestine, reabsorption in the kidney, and mobilization of calcium and phosphate from bone. Thus, chronic renal failure is associated with hyperparathyroidism, which in turn contributes to osteomalacia (softening of the bones). Another complication of chronic renal failure is hyperphosphatemia (low levels of phosphate in the blood). Hyperphosphatemia (excess levels of phosphate in the blood) is a prevalent condition in kidney dialysis patients and is associated with increased risk of mortality. Hypophosphatemia (hungry bone syndrome) has been associated to postoperative electrolyte aberrations and after parathyroidectomy. (PMID: 17581921, 11169009, 11039261, 9159312, 17625581)Fibroblast growth factor 23 (FGF-23) has recently been recognized as a key mediator of phosphate homeostasis, its most notable effect being promotion of phosphate excretion. FGF-23 was discovered to be involved in diseases such as autosomal dominant hypophosphatemic rickets, X-linked hypophosphatemia, and tumor-induced osteomalacia in which phosphate wasting was coupled to inappropriately low levels of 1,25(OH)2D3. FGF-23 is regulated by dietary phosphate in humans. In particular it was found that phosphate restriction decreased FGF-23, and phosphate loading increased FGF-23.
14265-44-2
C00009
1061
18367
CPD-8587
1032
OP(O)(O)=O
H3O4P
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
NBIIXXVUZAFLBC-UHFFFAOYSA-N
97.9952
97.976895096
DBMET00532
FDB022617
Nfb orthophosphate;O-phosphoric acid;Ortho-phosphate;Orthophosphate (po43-);Orthophosphate(3-);Phosphate;Phosphate (po43-);Phosphate anion(3-);Phosphate ion (po43-);Phosphate ion(3-);Phosphate trianion;Phosphate(3-);Phosphoric acid ion(3-);Pi;[po4](3-);Orthophosphate;Phosphate ion;Po4(3-);Phosphoric acid;Orthophosphoric acid;Phosphoric acid ion
PW_C001104
Pi
24
4
84
8
814
5
818
18
831
2
980
3
1763
14
1767
49
2500
10
2729
47
2737
46
3129
29
3166
72
3636
61
3851
23
4249
22
4475
31
5031
27
5158
7
5207
97
5216
100
5317
111
5351
112
5381
103
5447
120
5543
129
5573
133
5605
135
5625
108
5693
6
5848
143
5855
146
5911
147
5941
151
6040
155
6100
161
6294
107
6487
178
6691
101
6714
117
6842
188
6889
160
7161
205
7189
206
7212
211
7306
198
7389
210
7402
212
7436
163
7475
222
8196
225
8258
227
10118
241
10134
257
11748
132
11761
115
11773
213
11904
170
11927
164
12014
281
12728
290
13263
223
34819
17
42255
304
42350
315
42435
318
43692
322
77018
253
77194
293
77217
134
77940
336
77966
130
78048
332
78057
329
78245
353
78669
331
80022
368
89279
308
93831
383
94796
384
110558
390
110640
391
113235
94
115845
398
116206
109
119982
406
120069
122
120699
407
121057
124
121216
125
121268
429
121352
121
121409
123
121423
382
121852
405
123304
119
123621
118
123786
136
123838
464
123968
447
123981
399
124405
376
124948
472
125362
479
125446
297
125774
481
125954
299
126221
478
126594
300
126604
298
126723
484
126904
501
127413
388
127783
209
128166
395
128177
513
128315
389
204
Uracil
HMDB0000300
Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thymine. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for many important biochemical reactions. UDP and UTP regulate CPSase II activity in animals. UDP-glucose regulates the conversion of glucose to galactose in the liver and other tissues in the process of carbohydrate metabolism. Uracil is also involved in the biosynthesis of polysaccharides and the transportation of sugars containing aldehydes.
66-22-8
C00106
1174
17568
URACIL
1141
DB03419
O=C1NC=CC(=O)N1
C4H4N2O2
InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
ISAKRJDGNUQOIC-UHFFFAOYSA-N
112.0868
112.027277382
FDB006426
2,4-dihydroxypyrimidine;2,4-dioxopyrimidine;2,4-pyrimidinediol;2,4-pyrimidinedione;Hybar x;Pirod;Pyrod;Uracil;Sq-8493sid51088798;Sq-6201sq-7726sid70371;Bms-205603-01uracil
PW_C000204
Uracil
538
8
2741
2
77589
111
78739
132
120451
122
122220
124
123085
135
124772
118
125695
297
126383
299
127189
205
127943
388
8
Deoxycytidine
HMDB0000014
One of the principal nucleosides of DNA composed of cytosine and deoxyribose. A nucleoside consists of only a pentose sugar linked to a purine or pyrimidine base, without a phosphate group. When N1 is linked to the C1 of deoxyribose, deoxynucleosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), deoxycytidine triphosphate (dCTP). CTP is the source of the cytidine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of the deoxycytidine in DNA (deoxyribonucleic acid).
951-77-9
C00881
13711
15698
DEOXYCYTIDINE
13117
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1
C9H13N3O4
InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
CKTSBUTUHBMZGZ-SHYZEUOFSA-N
227.2172
227.090605919
FDB021871
1-(2-deoxy-b-d-ribofuranosyl)cytosine;1-(2-deoxy-beta-d-erythro-pentofuranosyl)-cytosine;1-(2-deoxy-beta-d-ribofuranosyl)cytosine;1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-cytosine;1-(2-deoxy-beta-delta-ribofuranosyl)cytosine;2'-deoxycytidine;2-deoxy-cytidine;4-amino-1-(2-deoxy-b-d-erythro-pentofuranosyl)-2(1h)-pyrimidinone;4-amino-1-(2-deoxy-beta-d-erythro-pentofuranosyl)-2(1h)-pyrimidinone;4-amino-1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2(1h)-pyrimidinone;Cytosine deoxyribonucleoside;Cytosine deoxyriboside;Deoxy-cytidine;Deoxyribose cytidine;Desoxycytidine;4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1h)-one;Dc;Dcyd;Deoxycytidine
PW_C000008
DC
2753
2
6743
107
6744
108
12749
151
12763
294
43714
315
43716
318
78744
132
122229
124
124781
118
126393
299
127954
388
40034
Hydrogen Ion
HMDB0059597
Hydrogen ion is recommended by IUPAC as a general term for all ions of hydrogen and its isotopes. Depending on the charge of the ion, two different classes can be distinguished: positively charged ions and negatively charged ions. Under aqueous conditions found in biochemistry, hydrogen ions exist as the hydrated form hydronium, H3O+, but these are often still referred to as hydrogen ions or even protons by biochemists. [WikiPedia])
C00080
1038
15378
1010
[H+]
H
InChI=1S/p+1
GPRLSGONYQIRFK-UHFFFAOYSA-N
1.0079
1.007825032
H+;H(+);Hydrogen cation;Hydron;Proton
PW_C040034
H+
215
4
670
8
753
15
788
31
848
3
1116
2
1463
26
1464
54
2231
49
2780
17
4250
22
4254
42
4547
10
4576
18
4694
70
5241
103
5327
111
5353
112
5626
108
5639
107
5699
100
5720
105
5742
117
5963
147
6037
155
6070
157
6093
161
6130
159
6232
166
6483
178
6601
152
6692
101
6843
188
6910
187
7100
163
7168
205
7191
206
7453
219
7454
220
7472
222
7525
213
7532
210
7558
212
7572
160
7590
170
8195
225
8218
151
8243
226
8413
162
8420
224
9139
195
9155
249
11915
164
12015
281
12181
285
12246
286
12266
287
12521
227
13257
223
13325
294
15330
308
42329
315
42354
318
42401
322
42405
312
42454
320
76912
293
77136
133
77210
134
77372
331
77804
114
77955
132
77990
327
77991
347
78379
345
79929
130
80019
368
80387
310
80388
304
80722
119
93823
124
94823
383
110550
388
112855
94
113280
390
115537
398
115539
118
115856
336
116205
109
119973
406
120193
407
120549
122
120593
409
121170
424
121171
425
122569
418
122615
384
122687
125
122758
120
123183
135
123218
137
123742
459
123743
460
125141
454
125188
121
125273
136
125359
479
125550
481
125730
483
125736
297
125809
299
126517
495
126717
489
126766
480
126823
300
126902
501
127213
208
128308
506
128361
391
128430
395
140692
882
140693
883
140699
167
140707
168
140715
14
140742
788
140743
597
140760
185
187
Thymidine
HMDB0000273
Thymidine is non-toxic and is a naturally occurring compound that exists in all living organisms and DNA viruses. 25% of DNA is composed of thymidine. RNA does not have thymidine and has uridine instead. Thymidine is a chemical compound which is a pyrimidine nucleoside. Thymidine is the DNA base T, which pairs with adenosine in double stranded DNA.
50-89-5
C00214
5789
17748
THYMIDINE
5585
DB04485
CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
C10H14N2O5
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
IQFYYKKMVGJFEH-XLPZGREQSA-N
242.2286
242.090271568
FDB012757
1-(2-deoxy-b-d-erythro-pentofuranosyl)-5-methyl-2,4(1h,3h)-pyrimidinedione;1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-5-methyl-2,4(1h,3h)-pyrimidinedione;1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione;2'-deoxy-5-methyl-uridine;2'-deoxythymidine;5-methyl-2'-deoxyuridine;5-methyldeoxyuridine;Dt;Dthyd;Deoxyribothymidine;Deoxythymidine;Thymidin;Thymidine;Thymine 2-desoxyriboside;Thymine deoxyriboside;Thymine-1 2-deoxy-b-d-ribofuranoside;Thymine-1 2-deoxy-beta-delta-ribofuranoside;1-(2-deoxy-beta-d-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1h,3h)-dione;2'-deoxy-5-methyluridine;2'-thymidine;Dthd;T;Thymine 2'-deoxyriboside;1-(2-deoxy-b-d-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1h,3h)-dione;1-(2-deoxy-β-d-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1h,3h)-dione
PW_C000187
T
2773
2
6752
107
6753
108
12758
151
12765
294
43725
318
43726
315
78751
132
122241
124
124794
118
126404
299
127967
388
179
Thymine
HMDB0000262
One of the pyrimidine bases of living matter. Derivation: Hydrolysis of deoxyribonucleic acid, from methylcyanoacetylurea by catalytic reduction. Use: Biochemical research. (Hawley's Condensed Chemical Dictionary). Thymine is a pyrimidine nucleobase. As the name implies, thymine may be derived by methylation of uracil at the 5th carbon. Thymine is found in the nucleic acid DNA. In RNA thymine is replaced with uracil in most cases. In DNA, thymine binds to adenine via two hydrogen bonds to assist in stabilizing the nucleic acid structures.
65-71-4
C00178
1135
17821
THYMINE
1103
DB03462
CC1=CNC(=O)NC1=O
C5H6N2O2
InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
RWQNBRDOKXIBIV-UHFFFAOYSA-N
126.1133
126.042927446
FDB021922
2,4-dihydroxy-5-methylpyrimidine;4-hydroxy-5-methylpyrimidin-2(1h)-one;5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-methyl-2,4(1h,3h)-pyrimidinedione;5-methyl-2,4-dihydroxypyrimidine;5-methylpyrimidine-2,4-dione;5-methyluracil;Thymine
PW_C000179
Thymine
2782
2
78752
132
122242
124
124795
118
126405
299
127968
388
1042
Deoxyribose 1-phosphate
HMDB0001351
Deoxyribose 1-phosphate belongs to the class of organic compounds known as pentoses. These are monosaccharides in which the carbohydrate moiety contains five carbon atoms. Deoxyribose 1-phosphate is soluble (in water) and a moderately acidic compound (based on its pKa). Within the cell, deoxyribose 1-phosphate is primarily located in the cytoplasm. Deoxyribose 1-phosphate exists in all living organisms, ranging from bacteria to humans. Deoxyribose 1-phosphate participates in a number of enzymatic reactions. In particular, Hypoxanthine and deoxyribose 1-phosphate can be biosynthesized from deoxyinosine through its interaction with the enzyme purine nucleoside phosphorylase. Furthermore, Adenine and deoxyribose 1-phosphate can be biosynthesized from deoxyadenosine through its interaction with the enzyme purine nucleoside phosphorylase. Furthermore, Uracil and deoxyribose 1-phosphate can be biosynthesized from deoxyuridine through its interaction with the enzyme thymidine phosphorylase / uracil phosphorylase. Finally, Thymine and deoxyribose 1-phosphate can be biosynthesized from thymidine; which is catalyzed by the enzyme thymidine phosphorylase / uracil phosphorylase. In humans, deoxyribose 1-phosphate is involved in the thioguanine action pathway, the azathioprine action pathway, the mercaptopurine action pathway, and the purine metabolism pathway. Deoxyribose 1-phosphate is also involved in several metabolic disorders, some of which include the gout or kelley-seegmiller syndrome pathway, purine nucleoside phosphorylase deficiency, UMP synthase deficiency (orotic aciduria), and molybdenum cofactor deficiency. Deoxyribose 1-phosphate is an intermediate in the metabolism of Pyrimidine. It is a substrate for Purine nucleoside phosphorylase and Thymidine phosphorylase.
17210-42-3
C00672
439287
28542
DEOXY-RIBOSE-1P
388420
OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O
C5H11O7P
InChI=1S/C5H11O7P/c6-2-4-3(7)1-5(11-4)12-13(8,9)10/h3-7H,1-2H2,(H2,8,9,10)/t3-,4+,5?/m0/s1
KBDKAJNTYKVSEK-PYHARJCCSA-N
214.1104
214.024239218
FDB022571
2-deoxy-d-erythro-pentofuranose 1-phosphate;2-deoxy-d-ribose 1-phosphate;2-deoxy-d-ribose-1-phosphate;2-deoxy-alpha-d-ribose 1-phosphate;2-deoxy-alpha-delta-ribose 1-phosphate;2-deoxy-delta-erythro-pentofuranose 1-phosphate;2-deoxy-delta-ribose 1-phosphate;2-deoxy-delta-ribose-1-phosphate;2-deoxyribofuranose 1-phosphate;D-2-deoxy-ribofuranose 1-phosphate;Deoxyribose 1-phosphate;Deoxyribose-1-phosphate;Delta-2-deoxy-ribofuranose 1-phosphate;2-deoxy-1-o-phosphono-d-erythro-pentofuranose;2-deoxy-1-o-phosphono-d-ribofuranose
PW_C001042
D1P
1801
2
1823
8
11784
198
77189
132
78678
111
121867
122
122198
124
124420
135
124750
118
126358
299
127921
388
1420
Water
HMDB0002111
Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).
7732-18-5
C00001
962
15377
937
O
H2O
InChI=1S/H2O/h1H2
XLYOFNOQVPJJNP-UHFFFAOYSA-N
18.0153
18.010564686
FDB013390
Dihydrogen oxide;Steam;[oh2];Acqua;Agua;Aqua;Bound water;Dihydridooxygen;Eau;H2o;Hoh;Hydrogen hydroxide;Wasser
PW_C001420
H2O
55
8
94
9
109
5
139
4
151
3
162
14
481
13
526
15
624
28
652
10
691
20
770
33
823
18
838
2
1094
31
1377
49
1465
54
1590
43
2018
24
2532
22
2678
60
2727
46
2778
17
2805
29
3143
70
3164
72
3634
61
4598
36
4727
37
4941
93
5030
27
5156
7
5195
97
5214
100
5227
94
5236
103
5297
105
5319
111
5343
113
5355
112
5402
110
5470
123
5483
125
5492
126
5507
127
5534
130
5537
114
5541
129
5591
135
5608
118
5622
108
5691
6
5759
140
5778
101
5841
143
5853
146
5877
107
5890
95
5910
147
5940
151
6032
155
6059
157
6087
161
6123
163
6133
159
6215
1
6218
166
6477
178
6507
180
6600
152
6713
117
6840
188
6888
160
7162
205
7181
207
7193
206
7211
211
7228
213
7238
214
7243
215
7295
198
7350
216
7388
210
7401
212
7467
222
7492
224
7500
190
7588
170
8201
225
8237
226
8414
162
9265
26
11850
277
11922
164
12011
281
12213
285
12250
286
12264
287
12327
249
12520
227
12632
65
12693
290
12705
291
12715
292
13007
298
13019
300
13025
301
13037
302
13261
223
13327
294
15340
308
42327
315
42695
318
43691
322
76914
293
77019
253
77102
132
77131
133
77215
134
77378
331
77397
332
77471
333
77516
115
77536
334
77628
336
77722
337
77759
341
77816
343
77982
347
78071
329
78235
352
78242
353
78270
356
79113
360
80014
368
80039
370
80591
228
80656
119
93830
383
94794
384
110557
390
110639
391
115844
398
119879
232
119915
122
119963
406
120008
407
120046
408
120113
124
120365
412
120430
405
120438
409
120606
415
120794
414
121158
425
121240
429
121351
121
121381
419
121607
434
122118
382
122384
436
122753
120
122797
374
122804
443
123012
446
123064
376
123072
137
123131
447
123142
136
123162
448
123231
451
123384
450
123730
460
123810
464
123940
455
124165
469
124670
399
124938
471
124945
472
125305
297
125353
479
125386
481
125424
482
125480
299
125682
483
125707
478
125745
487
126054
490
126238
495
126273
484
126764
480
126896
501
126963
502
127017
388
127177
208
127199
209
127227
504
127506
507
127576
515
127836
389
128082
395
128176
513
140674
790
140675
834
140755
185
22608
Ammonium
HMDB0041827
Ammonium is an important source of nitrogen for many plant species, especially those growing on hypoxic soils. However, it is also toxic to most crop species and is rarely applied as a sole nitrogen source. The ammonium (more obscurely: aminium) cation is a positively charged polyatomic cation with the chemical formula NH4+. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR4+), where one or more hydrogen atoms are replaced by organic radical groups (indicated by R).
14798-03-9
C01342
16741146
28938
218
[NH4+]
H4N
InChI=1S/H3N/h1H3/p+1
QGZKDVFQNNGYKY-UHFFFAOYSA-O
18.0385
18.034374133
Ammonium ion;Ammonia ion;Ammonium;Ammonium chloride;Ammonium(1+);Azanium;Nh4+;[nh4]+;[nh4](+);Nh4(+)
PW_C022608
Ammon
5751
108
5892
95
5969
100
6226
166
8273
151
8367
225
11909
170
12470
249
42627
315
116281
109
7057
Nucleoside permease nupC
P0AFF2
Involved in nucleoside:sodium symporter activity. Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force.
nupC
b2393
AP009048
3
8888
109
5930
Thymidine phosphorylase
P07650
Involved in transferase activity, transferring glycosyl groups. The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
deoA
b4382
AP009048
3
2.4.2.4
135965
304
7058
Nucleoside permease nupG
P0AFF4
Involved in nucleoside transmembrane transporter activity. Transports nucleosides with a high affinity. Driven by a proton motive force.
nupG
b2964
AP009048
3
8629
109
6175
Cytidine deaminase
P0ABF6
Involved in zinc ion binding. This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
cdd
b2143
AP009048
3
3.5.4.5
135966
304
4042
nucleoside:H+ symporter NupC
3
PW_P004042
11043
7057
4044
thymidine phosphorylase / uracil phosphorylase
3
PW_P004044
11045
5930
2
3972
nucleoside:H+ symporter NupG
3
PW_P003972
10960
7058
3973
cytidine deaminase
3
PW_P003973
10961
6175
2
6032
false
PW_R006032
Both
24661
187
1
Compound
false
24662
1104
1
Compound
false
24663
179
1
Compound
false
24664
1042
1
Compound
false
5997
4044
6018
false
PW_R006018
Right
24597
7
1
Compound
false
24598
1104
1
Compound
true
24599
204
1
Compound
false
24600
1042
1
Compound
true
5979
4044
2.4.2.4
6014
false
PW_R006014
Right
24575
8
1
Compound
false
24576
1420
1
Compound
false
24577
40034
1
Compound
false
24578
22608
1
Compound
false
24579
7
1
Compound
false
5975
3973
503
PW_T000503
635
187
1
Compound
107
108
Right
636
40034
1
Compound
107
108
Right
434
4042
2015-10-09T13:13:23-06:00
2015-10-09T13:13:23-06:00
109
504
PW_T000504
637
187
1
Compound
107
108
Right
638
40034
1
Compound
107
108
Right
435
3972
2015-10-09T13:14:48-06:00
2015-10-09T13:14:48-06:00
109
498
PW_T000498
625
8
1
Compound
107
108
Right
626
40034
1
Compound
107
108
Right
429
3972
2015-10-09T10:52:55-06:00
2015-10-09T10:52:55-06:00
109
499
PW_T000499
627
8
1
Compound
107
108
Right
628
40034
1
Compound
107
108
Right
430
4042
2015-10-09T10:58:42-06:00
2015-10-09T10:58:42-06:00
109
71035
7
3
false
1574
517
10
regular
100
100
71036
1104
46
false
1670
705
10
regular
44
43
71037
204
3
false
1678
907
10
regular
100
100
71045
8
107
3
false
301
402
10
regular
100
100
71047
40034
107
55
false
466
413
10
regular
78
78
71048
40034
108
55
false
816
413
10
regular
78
78
71050
8
108
3
false
946
517
10
regular
100
100
71053
187
3
false
895
1098
10
regular
100
100
71054
1104
46
false
1050
1202
10
regular
44
43
71055
179
3
false
1326
1203
10
regular
100
100
71056
1042
3
false
1576
1093
10
regular
100
110
71057
187
107
3
false
356
1100
10
regular
100
100
71059
40034
107
55
false
491
1190
10
regular
78
78
71060
40034
108
55
false
802
1195
10
regular
78
78
71063
40034
107
55
false
507
955
10
regular
78
78
71064
40034
108
55
false
817
790
10
regular
78
78
2679014
187
108
3
false
381
870
10
regular
100
100
2679015
1420
304
49
false
1072
446
10
regular
78
78
2679016
40034
304
55
false
1187
444
10
regular
78
78
2679017
22608
304
3
false
1474
427
10
regular
100
100
32585
7057
109
76
false
610
532
8
subunit
regular
150
70
32587
5930
6
false
1146
1108
8
subunit
regular
160
80
32588
7057
109
76
false
611
1114
8
subunit
regular
150
70
32589
7058
109
76
false
611
884
8
subunit
regular
150
70
948352
5930
304
6
false
1542
794
8
subunit
regular
160
80
948353
7058
76
false
610
287
8
subunit
regular
150
70
948354
6175
304
6
false
1290
528
8
subunit
regular
160
80
27406
4042
1816
32266
32585
27408
4044
1816
32268
32587
27409
4042
1816
32269
32588
27410
3972
1816
32270
32589
803151
4044
1816
304
944223
948352
803152
3972
1816
944224
948353
803153
3973
1816
304
944225
948354
100930
M995 1148 C1038 1148 1113 1147 1146 1148
5
false
18
true
M 25.946855044164835 798.261556296296 L 11 797 L 17.380887721185843 810.5751343230784
false
100931
M1072 1202 C1071 1171 1065 1149 1146 1148
5
false
18
true
M 25.946855044164835 798.261556296296 L 11 797 L 17.380887721185843 810.5751343230784
false
100932
M1376 1203 C1376 1173 1376 1148 1306 1148
5
false
18
true
M 25.946855044164835 798.261556296296 L 11 797 L 17.380887721185843 810.5751343230784
false
100933
M1576 1148 C1514 1147 1345 1148 1306 1148
5
false
18
true
M 25.946855044164835 798.261556296296 L 11 797 L 17.380887721185843 810.5751343230784
false
3659978
M456 1150 C486 1150 581 1149 611 1149
83
false
18
3659979
M895 1148 C865 1148 791 1149 761 1149
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659980
M530 1190 C530 1142 581 1149 611 1149
83
false
18
3659981
M841 1195 C838 1145 791 1149 761 1149
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659986
M945 1098 C945 1049 945 988 945 920 C881 921 833 919 761 919
83
false
18
3659987
M481 920 C533 920 580 919 611 919
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659988
M546 955 C547 921 581 919 611 919
83
false
18
3659989
M856 868 C857 925 791 919 761 919
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659990
M1624 617 C1622 664 1624 756 1622 794
5
false
18
3659991
M1670 726.5 C1633 729.5 1624 745 1622 794
5
false
18
3659992
M1678 957 C1628 956 1622 934 1622 874
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659993
M1626 1093 C1625 989 1623 979 1622 874
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659994
M351 402 C352 375 352 358 352 323 C392 323 566 322 610 322
83
false
18
3659995
M996 517 C996 406 996 370 997 324 C940 324 928 324 760 322
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659996
M505 413 C505 335 559 323 610 322
83
false
18
3659997
M855 413 C854 377 848 323 760 322
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3659998
M351 502 C351 520 351 543 351 568 C393 569 571 567 610 567
83
false
18
3659999
M946 567 C868 567 867 566 760 567
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3660000
M505 491 C505 545 560 568 610 567
83
false
18
3660001
M855 491 C853 540 830 566 760 567
83
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3660002
M1046 567 C1158 570 1212 567 1290 568
5
false
18
3660003
M1111 524 C1111 577 1251 567 1290 568
5
false
18
3660004
M1226 522 C1228 563 1271 568 1290 568
5
false
18
3660005
M1524 527 C1525 561 1494 569 1450 568
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
3660006
M1574 567 C1503 569 1547 568 1450 568
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
20645
1816
6032
80199
71053
100930
Left
80200
71054
100931
Left
80201
71055
100932
Right
80202
71056
100933
Right
20831
5997
27408
797584
1816
6018
304
3223586
71035
3659990
Left
3223587
71036
3659991
Left
3223588
71037
3659992
Right
3223589
71056
3659993
Right
753245
5979
803151
797585
1816
6014
304
3223590
71050
3660002
Left
3223591
2679015
3660003
Left
3223592
2679016
3660004
Left
3223593
2679017
3660005
Right
3223594
71035
3660006
Right
753246
5975
803153
78067
503
1816
156907
71057
3659978
Left
156908
71053
3659979
Right
156909
71059
3659980
Left
156910
71060
3659981
Right
24700
27409
434
78069
504
1816
156915
71053
3659986
Left
156916
2679014
3659987
Right
156917
71063
3659988
Left
156918
71064
3659989
Right
24702
27410
435
78070
498
1816
156919
71045
3659994
Left
156920
71050
3659995
Right
156921
71047
3659996
Left
156922
71048
3659997
Right
24703
803152
429
78071
499
1816
156923
71045
3659998
Left
156924
71050
3659999
Right
156925
71047
3660000
Left
156926
71048
3660001
Right
24704
27406
430
186430
1031
606
1.0
1.0
0
2
92
479
481
369659
M228 326 C228 276 278 226 328 226 C752 226 1303 226 1727 226 C1777 226 1827 276 1827 326 C1827 614 1827 990 1827 1278 C1827 1328 1777 1378 1727 1378 C1303 1378 752 1378 328 1378 C278 1378 228 1328 228 1278 C228 990 228 614 228 326
1
true
6
1599.0
1152.0
369660
M125 225 C125 175 175 125 225 125 C710 125 1342 125 1827 125 C1877 125 1927 175 1927 225 C1927 575 1927 1029 1927 1379 C1927 1429 1877 1479 1827 1479 C1342 1479 710 1479 225 1479 C175 1479 125 1429 125 1379 C125 1029 125 575 125 225
1
true
6
1802.0
1354.0