1875
Pathway
D-Serine Degradation
The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate.
Metabolic
PW002101
Center
PathwayVisualizationContext2388
1950
1998
#FFFFFF
PathwayVisualization1859
1875
D-Serine Degradation
The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate.
Metabolic
3
3946
17785472
Anfora AT, Haugen BJ, Roesch P, Redford P, Welch RA: Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073. Infect Immun. 2007 Nov;75(11):5298-304. doi: 10.1128/IAI.00652-07. Epub 2007 Sep 4.
1875
Pathway
3947
1090588
Bloom FR, McFall E: Isolation and characterization of D-serine deaminase constitutive mutants by utilization of D-serine as sole carbon or nitrogen source. J Bacteriol. 1975 Mar;121(3):1078-84.
1875
Pathway
3948
4574697
Cosloy SD, McFall E: Metabolism of D-serine in Escherichia coli K-12: mechanism of growth inhibition. J Bacteriol. 1973 May;114(2):685-94.
1875
Pathway
3949
14216615
MCFALL E: GENETIC STRUCTURE OF THE D-SERINE DEAMINASE SYSTEM OF ESCHERICHIA COLI. J Mol Biol. 1964 Sep;9:746-53.
1875
Pathway
3950
14216616
MCFALL E: PLEIOTROPIC MUTATIONS IN THE D-SERINE DEAMINASE SYSTEM OF ESCHERICHIA COLI. J Mol Biol. 1964 Sep;9:754-62.
1875
Pathway
3951
17088369
Moritz RL, Welch RA: The Escherichia coli argW-dsdCXA genetic island is highly variable, and E. coli K1 strains commonly possess two copies of dsdCXA. J Clin Microbiol. 2006 Nov;44(11):4038-48. doi: 10.1128/JCM.01172-06.
1875
Pathway
3952
13271312
PARDEE AB, PRESTIDGE LS: Induced formation of serine and threonine deaminases by Escherichia coli. J Bacteriol. 1955 Dec;70(6):667-74.
1875
Pathway
3953
12823810
Roesch PL, Redford P, Batchelet S, Moritz RL, Pellett S, Haugen BJ, Blattner FR, Welch RA: Uropathogenic Escherichia coli use d-serine deaminase to modulate infection of the murine urinary tract. Mol Microbiol. 2003 Jul;49(1):55-67.
1875
Pathway
3954
19674114
Sakinc T, Michalski N, Kleine B, Gatermann SG: The uropathogenic species Staphylococcus saprophyticus tolerates a high concentration of D-serine. FEMS Microbiol Lett. 2009 Oct;299(1):60-4. doi: 10.1111/j.1574-6968.2009.01731.x. Epub 2009 Jul 17.
1875
Pathway
1
Cell
CL:0000000
5
Hepatocyte
CL:0000182
4
Cardiomyocyte
CL:0000746
3
Neuron
CL:0000540
7
Epithelial Cell
CL:0000066
6
Myocyte
CL:0000187
10
Glial cell
CL:0000125
1
Homo sapiens
9606
Eukaryote
Human
12
Mus musculus
10090
Eukaryote
Mouse
4
Arabidopsis thaliana
3702
Eukaryote
Thale cress
2
Bacteria
2
Prokaryote
Bacteria
3
Escherichia coli
562
Prokaryote
5
Bos taurus
9913
Eukaryote
Cattle
17
Rattus norvegicus
10116
Eukaryote
Rat
19
Schizosaccharomyces pombe
4896
Eukaryote
24
Solanum lycopersicum
4081
Eukaryote
Tomato
18
Saccharomyces cerevisiae
4932
Eukaryote
Yeast
21
Xenopus laevis
8355
Eukaryote
African clawed frog
6
Caenorhabditis elegans
6239
Eukaryote
Roundworm
25
Escherichia coli (strain K12)
83333
Prokaryote
49
Bathymodiolus platifrons
220390
Eukaryote
Deep sea mussel
10
Drosophila melanogaster
7227
Eukaryote
Fruit fly
23
Pseudomonas aeruginosa
287
Prokaryote
60
Nitzschia sp.
0001
Eukaryote
Nitzschia4
1
Cytosol
GO:0005829
5
Cytoplasm
GO:0005737
6
Lysosome
GO:0005764
4
Peroxisome
GO:0005777
3
Mitochondrial Matrix
GO:0005759
2
Mitochondrion
GO:0005739
10
Cell Membrane
GO:0005886
11
Extracellular Space
GO:0005615
16
Lysosomal Lumen
GO:0043202
7
Endoplasmic Reticulum Membrane
GO:0005789
18
Melanosome Membrane
GO:0033162
13
Endoplasmic Reticulum
GO:0005783
25
Golgi apparatus
GO:0005794
14
Mitochondrial Outer Membrane
GO:0005741
12
Mitochondrial Inner Membrane
GO:0005743
20
Endoplasmic Reticulum Lumen
GO:0005788
21
Synapse
GO:0045202
15
Nucleus
GO:0005634
31
Periplasmic Space
GO:0005620
35
Chloroplast
GO:0009507
36
Membrane
GO:0016020
53
Endoplasmic Reticulum Body
GO:0010168
34
Plant-Type Vacuole
GO:0000325
40
Periplasm
GO:0042597
24
Mitochondrial Intermembrane Space
GO:0005758
32
Inner Membrane
GO:0070258
1
Liver
BTO:0000759
72
9
4
Adrenal Medulla
BTO:0000049
71
8
25
Intestine
BTO:0000648
28
Stomach
BTO:0001307
155
26
7
Nervous System
BTO:0001484
8
Blood Vessel
BTO:0001102
74
11
11
Heart
BTO:0000562
73
10
9
Muscle
BTO:0000887
141
18
24
Brain
BTO:0000142
89
16
2
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1
1
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PW_BS000170
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3
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136
13
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PW_BS000136
448
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18
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1
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PW_BS000113
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25
17
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PW_BS000115
297
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10
1
PW_BS000024
479
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481
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482
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299
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10
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1938
2-Aminoacrylic acid
HMDB0003609
2-Aminoacrylic acid, also known as 2,3-didehydroalanine or 2-aminoacrylate, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). 2-Aminoacrylic acid is soluble (in water) and a moderately acidic compound (based on its pKa). In humans, 2-aminoacrylic acid is involved in thyroid hormone synthesis pathway. Outside of the human body, 2-aminoacrylic acid can be found in a number of food items such as evergreen huckleberry, welsh onion, japanese pumpkin, and lemon grass. This makes 2-aminoacrylic acid a potential biomarker for the consumption of these food products. Dehydroalanine (or (alpha)-(beta)-di-dehydroalanine) is an uncommon amino acid found in peptides of microbial origin (an unsaturated amino acid).
1948-56-7
C02218
123991
17123
110510
DB02688
NC(=C)C(O)=O
C3H5NO2
InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6)
UQBOJOOOTLPNST-UHFFFAOYSA-N
2-aminoprop-2-enoic acid
87.0773
87.032028409
0.43
2
dehydroalanine
0
0
FDB023206
(alpha)-(beta)-di-dehydroalanine;2-aminoacrylate;2-aminoacrylic acid;Dehydroalanine;A-b-di-dehydroalanine;Alpha-beta-di-dehydroalanine;2-aminoprop-2-enoate;2-aminoprop-2-enoic acid
PW_C001938
2Amnaa
4537
2
79043
132
40928
2-iminopropanoate
2-Iminopropanoate belongs to the class of organic compounds known as ketimines. These are organic compounds bearing the ketimine functional group, with the general structure R2C=NR' ( R is not a hydrogen ). 2-Iminopropanoate is slightly soluble (in water) and a weakly acidic compound (based on its pKa).
77456
CC(=N)C([O-])=O
C3H4NO2
InChI=1S/C3H5NO2/c1-2(4)3(5)6/h4H,1H3,(H,5,6)/p-1
DUAWRLXHCUAWMK-UHFFFAOYSA-M
2-iminopropanoate
86.071
86.024751953
-1.21
1
2-iminopropanoate
-1
0
PW_C040928
2-Isopa
8366
151
1420
Water
HMDB0002111
Water is a chemical substance that is essential to all known forms of life. It appears colorless to the naked eye in small quantities, though it is actually slightly blue in color. It covers 71% of Earth's surface. Current estimates suggest that there are 1.4 billion cubic kilometers (330 million m3) of it available on Earth, and it exists in many forms. It appears mostly in the oceans (saltwater) and polar ice caps, but it is also present as clouds, rain water, rivers, freshwater aquifers, lakes, and sea ice. Water in these bodies perpetually moves through a cycle of evaporation, precipitation, and runoff to the sea. Clean water is essential to human life. In many parts of the world, it is in short supply. From a biological standpoint, water has many distinct properties that are critical for the proliferation of life that set it apart from other substances. It carries out this role by allowing organic compounds to react in ways that ultimately allow replication. All known forms of life depend on water. Water is vital both as a solvent in which many of the body's solutes dissolve and as an essential part of many metabolic processes within the body. Metabolism is the sum total of anabolism and catabolism. In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). Water is thus essential and central to these metabolic processes. Water is also central to photosynthesis and respiration. Photosynthetic cells use the sun's energy to split off water's hydrogen from oxygen. Hydrogen is combined with CO2 (absorbed from air or water) to form glucose and release oxygen. All living cells use such fuels and oxidize the hydrogen and carbon to capture the sun's energy and reform water and CO2 in the process (cellular respiration). Water is also central to acid-base neutrality and enzyme function. An acid, a hydrogen ion (H+, that is, a proton) donor, can be neutralized by a base, a proton acceptor such as hydroxide ion (OH-) to form water. Water is considered to be neutral, with a pH (the negative log of the hydrogen ion concentration) of 7. Acids have pH values less than 7 while bases have values greater than 7. Stomach acid (HCl) is useful to digestion. However, its corrosive effect on the esophagus during reflux can temporarily be neutralized by ingestion of a base such as aluminum hydroxide to produce the neutral molecules water and the salt aluminum chloride. Human biochemistry that involves enzymes usually performs optimally around a biologically neutral pH of 7.4. (Wikipedia).
7732-18-5
C00001
962
15377
937
O
H2O
InChI=1S/H2O/h1H2
XLYOFNOQVPJJNP-UHFFFAOYSA-N
water
18.0153
18.010564686
1
water
0
0
FDB013390
Dihydrogen oxide;Steam;[oh2];Acqua;Agua;Aqua;Bound water;Dihydridooxygen;Eau;H2o;Hoh;Hydrogen hydroxide;Wasser
PW_C001420
H2O
55
8
94
9
109
5
139
4
151
3
162
14
481
13
526
15
624
28
652
10
691
20
770
33
823
18
838
2
1094
31
1377
49
1465
54
1590
43
2018
24
2532
22
2678
60
2727
46
2778
17
2805
29
3143
70
3164
72
3634
61
4598
36
4727
37
4941
93
5030
27
5156
7
5195
97
5214
100
5227
94
5236
103
5297
105
5319
111
5343
113
5355
112
5402
110
5470
123
5483
125
5492
126
5507
127
5534
130
5537
114
5541
129
5591
135
5608
118
5622
108
5691
6
5759
140
5778
101
5841
143
5853
146
5877
107
5890
95
5910
147
5940
151
6032
155
6059
157
6087
161
6123
163
6133
159
6215
1
6218
166
6477
178
6507
180
6600
152
6713
117
6840
188
6888
160
7162
205
7181
207
7193
206
7211
211
7228
213
7238
214
7243
215
7295
198
7350
216
7388
210
7401
212
7467
222
7492
224
7500
190
7588
170
8201
225
8237
226
8414
162
9265
26
11850
277
11922
164
12011
281
12213
285
12250
286
12264
287
12327
249
12520
227
12632
65
12693
290
12705
291
12715
292
13007
298
13019
300
13025
301
13037
302
13261
223
13327
294
15340
308
42327
315
42695
318
43691
322
76914
293
77019
253
77102
132
77131
133
77215
134
77378
331
77397
332
77471
333
77516
115
77536
334
77628
336
77722
337
77759
341
77816
343
77982
347
78071
329
78235
352
78242
353
78270
356
79113
360
80014
368
80039
370
80591
228
80656
119
93830
383
94794
384
110557
390
110639
391
115844
398
119879
232
119915
122
119963
406
120008
407
120046
408
120113
124
120365
412
120430
405
120438
409
120606
415
120794
414
121158
425
121240
429
121351
121
121381
419
121607
434
122118
382
122384
436
122753
120
122797
374
122804
443
123012
446
123064
376
123072
137
123131
447
123142
136
123162
448
123231
451
123384
450
123730
460
123810
464
123940
455
124165
469
124670
399
124938
471
124945
472
125305
297
125353
479
125386
481
125424
482
125480
299
125682
483
125707
478
125745
487
126054
490
126238
495
126273
484
126764
480
126896
501
126963
502
127017
388
127177
208
127199
209
127227
504
127506
507
127576
515
127836
389
128082
395
128176
513
40034
Hydrogen Ion
HMDB0059597
Hydrogen ion is recommended by IUPAC as a general term for all ions of hydrogen and its isotopes. Depending on the charge of the ion, two different classes can be distinguished: positively charged ions and negatively charged ions. Under aqueous conditions found in biochemistry, hydrogen ions exist as the hydrated form hydronium, H3O+, but these are often still referred to as hydrogen ions or even protons by biochemists. [WikiPedia])
C00080
1038
15378
1010
[H+]
H
InChI=1S/p+1
GPRLSGONYQIRFK-UHFFFAOYSA-N
hydron
1.0079
1.007825032
0
hydron
1
0
H+;H(+);Hydrogen cation;Hydron;Proton
PW_C040034
H+
215
4
670
8
753
15
788
31
848
3
1116
2
1463
26
1464
54
2231
49
2780
17
4250
22
4254
42
4547
10
4576
18
4694
70
5241
103
5327
111
5353
112
5626
108
5639
107
5699
100
5720
105
5742
117
5963
147
6037
155
6070
157
6093
161
6130
159
6232
166
6483
178
6601
152
6692
101
6843
188
6910
187
7100
163
7168
205
7191
206
7453
219
7454
220
7472
222
7525
213
7532
210
7558
212
7572
160
7590
170
8195
225
8218
151
8243
226
8413
162
8420
224
9139
195
9155
249
11915
164
12015
281
12181
285
12246
286
12266
287
12521
227
13257
223
13325
294
15330
308
42329
315
42354
318
42401
322
42405
312
42454
320
76912
293
77136
133
77210
134
77372
331
77804
114
77955
132
77990
327
77991
347
78379
345
79929
130
80019
368
80387
310
80388
304
80722
119
93823
124
94823
383
110550
388
112855
94
113280
390
115537
398
115539
118
115856
336
116205
109
119973
406
120193
407
120549
122
120593
409
121170
424
121171
425
122569
418
122615
384
122687
125
122758
120
123183
135
123218
137
123742
459
123743
460
125141
454
125188
121
125273
136
125359
479
125550
481
125730
483
125736
297
125809
299
126517
495
126717
489
126766
480
126823
300
126902
501
127213
208
128308
506
128361
391
128430
395
22608
Ammonium
HMDB0041827
Ammonium is an important source of nitrogen for many plant species, especially those growing on hypoxic soils. However, it is also toxic to most crop species and is rarely applied as a sole nitrogen source. The ammonium (more obscurely: aminium) cation is a positively charged polyatomic cation with the chemical formula NH4+. It is formed by the protonation of ammonia (NH3). Ammonium is also a general name for positively charged or protonated substituted amines and quaternary ammonium cations (NR4+), where one or more hydrogen atoms are replaced by organic radical groups (indicated by R).
14798-03-9
C01342
16741146
28938
218
[NH4+]
H4N
InChI=1S/H3N/h1H3/p+1
QGZKDVFQNNGYKY-UHFFFAOYSA-O
azanium
18.0385
18.034374133
1
azanium
1
1
Ammonium ion;Ammonia ion;Ammonium;Ammonium chloride;Ammonium(1+);Azanium;Nh4+;[nh4]+;[nh4](+);Nh4(+)
PW_C022608
Ammon
5751
108
5892
95
5969
100
6226
166
8273
151
8367
225
11909
170
12470
249
42627
315
116281
109
164
Pyruvic acid
HMDB0000243
Pyruvic acid is an intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed.) Biological Source: Intermediate in primary metabolism including fermentation processes. Present in muscle in redox equilibrium with Lactic acid. A common constituent, as a chiral cyclic acetal linked to saccharide residues, of bacterial polysaccharides. Isolated from cane sugar fermentation broth and peppermint. Constituent of Bauhinia purpurea, Cicer arietinum (chickpea), Delonix regia, Pisum sativum (pea) and Trigonella caerulea (sweet trefoil) Use/Importance: Reagent for regeneration of carbonyl compdounds from semicarbazones, phenylhydrazones and oximes. Flavoring ingredient (Dictionary of Organic Compounds).
127-17-3
C00022
1060
32816
PYRUVATE
1031
DB00119
CC(=O)C(O)=O
C3H4O3
InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
LCTONWCANYUPML-UHFFFAOYSA-N
2-oxopropanoic acid
88.0621
88.016043994
0.18
1
pyruvic acid
0
-1
FDB008293
2-oxopropanoate;2-oxopropanoic acid;2-oxopropionate;2-oxopropionic acid;Acetylformate;Acetylformic acid;Bts;Pyroracemate;Pyroracemic acid;Pyruvate;A-ketopropionate;A-ketopropionic acid;Alpha-ketopropionate;Alpha-ketopropionic acid;2-ketopropionic acid;2-oxopropansaeure;2-oxopropionsaeure;Acide pyruvique;Alpha-oxopropionsaeure;Brenztraubensaeure;Ch3cocooh;2-ketopropionate;α-ketopropionate;α-ketopropionic acid;A-oxopropionsaeure;α-oxopropionsaeure
PW_C000164
Pyr
17
2
20
4
422
8
1181
3
1449
50
1457
26
5365
103
5405
117
5440
118
5444
120
5566
132
5570
133
5893
95
5920
147
5951
151
6022
155
6067
156
6074
161
6126
160
6383
1
6467
178
6510
177
6532
85
7457
222
7495
220
8200
225
12622
31
15292
249
15349
18
77310
111
77972
346
77978
327
78090
112
80004
368
80042
367
80695
135
112879
94
115683
121
119950
406
120011
124
120175
122
120878
407
121148
423
121154
424
123454
119
123720
458
123726
459
125340
479
125390
299
125534
297
125854
481
126883
501
126931
388
127067
205
127858
206
1875
D-Serine
HMDB0003406
D-Serine is a non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines, pyrimidines, and other amino acids. As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation. This might be important in explaining some of the devastating consequences of diabetes. It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signalling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Serine proteases are a common type of protease. Serine (IPA [sejin]), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the L-stereoisomer appears in mammalian protein. It is not essential to the human diet, since it can be synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serine's structure was established in 1902.
312-84-5
C00740
6857549
16523
Serines
64231
DB03929
N[C@H](CO)C(O)=O
C3H7NO3
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
MTCFGRXMJLQNBG-UWTATZPHSA-N
(2R)-2-amino-3-hydroxypropanoic acid
105.0926
105.042593095
0.66
3
D-serine
0
0
FDB023164
(2r)-2-amino-3-hydroxypropanoate;(2r)-2-amino-3-hydroxypropanoic acid;(r)-2-amino-3-hydroxypropanoate;(r)-2-amino-3-hydroxypropanoic acid;D-serin;Dl-serine;Dsn;Serine d-form;(r)-2-amino-3-hydroxy-propionic acid;(r)-2-amino-3-hydroxy-propionate
PW_C001875
D-Ser
3519
2
6813
107
6814
108
7088
202
7089
48
7094
71
7095
201
8361
219
8362
220
8363
151
43767
318
43768
315
78123
132
122172
124
124724
118
126330
299
127892
388
40711
4Fe-4S
HMDB0061380
Tetrakis(λ¹-iron(1+) ion) tetrasulfane tetrasulfanide belongs to the class of inorganic compounds known as transition metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
33723
S[Fe]12[S]3[Fe]4(S)[S]1[Fe]1(S)[S]2[Fe]3(S)[S]41
Fe4H4S8
InChI=1S/4Fe.4H2S.4S/h;;;;4*1H2;;;;/q4*+1;;;;;;;;/p-4
CFWDOBXUEATMSD-UHFFFAOYSA-J
tetrakis(lambda1-iron(1+) ion) tetrasulfane tetrasulfanide
483.932
483.54763418
0
tetrakis(lambda1-iron(1+) ion) tetrasulfane tetrasulfanide
0
1
PW_C040711
4Fe-4S
4738
3
4859
8
5051
4
5065
2
5403
110
6060
157
6124
163
6508
180
7493
224
12618
164
77160
112
78003
111
80040
370
80681
135
117797
133
117828
132
120009
407
120161
122
122658
406
122673
124
122784
119
125233
120
125248
118
125387
481
125522
297
126790
479
126806
299
126928
206
127057
205
128387
501
128404
388
6861
D-serine/D-alanine/glycine transporter
P0AAE1
Involved in transport. Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine.
cycA
AE005174
3
8603
109
6494
L-serine dehydratase 2
P30744
Involved in L-serine ammonia-lyase activity. Deaminates also threonine, particularly when it is present in high concentration.
sdaB
b2797
AP009048
3
4.3.1.17
1438
serine / alanine / glycine / cycloserine:H+symporter
3
PW_P001438
1679
6861
3799
L-serine deaminase II
3
PW_P003799
10726
6494
554
40711
2902
true
PW_R002902
Right
11528
1938
1
Compound
false
11529
40928
1
Compound
false
2903
true
PW_R002903
Right
11530
40928
1
Compound
false
11531
1420
1
Compound
false
11532
40034
1
Compound
false
11533
22608
1
Compound
false
11534
164
1
Compound
false
179447
PW_R179447
Right
677124
1875
1
Compound
false
677125
3799
1
ProteinComplex
false
179449
PW_R179449
Unknown
677130
3799
1
ProteinComplex
false
677131
1938
1
Compound
false
677132
1420
1
Compound
false
677133
40034
1
Compound
false
514
PW_T000514
654
1875
1
Compound
107
108
Right
655
40034
1
Compound
107
108
Right
443
1438
2015-10-14T10:35:16-06:00
2015-10-14T10:35:16-06:00
94
71674
1938
3
false
1203
1192
10
regular
100
110
71676
40928
3
false
1203
977
10
regular
100
110
71677
1420
49
false
1139
891
10
regular
78
78
71678
40034
55
false
1304
884
10
regular
78
78
71679
22608
3
false
1113
726
10
regular
100
100
71680
164
3
false
1203
616
10
regular
100
100
71686
1875
107
3
false
219
1192
10
regular
100
100
71687
1875
108
3
false
734
1192
10
regular
100
100
71688
40034
107
55
false
345
1292
10
regular
78
78
71689
40034
108
55
false
645
1292
10
regular
78
78
2679342
40711
9
false
939
1199
10
regular
100
25
2679348
1420
94
49
false
1109
1121
10
regular
78
78
2679349
40034
94
55
false
1094
1294
10
regular
78
78
32838
6861
109
76
false
449
1206
8
subunit
regular
150
70
948521
6494
2
false
919
1209
8
subunit
regular
150
70
27574
1438
1859
32519
32838
803256
3799
1859
944376
948521
36018
2679342
3660786
Cofactor
101735
M1303.3333333333335 1238 C1333.3333333333335 1238 1354.3333333333335 1192 1378.3333333333335 1238
5
true
18
101736
M1253 1087.5 C1253 1107.5 1253 1158.5 1253 1182.5
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
101737
M1253 977.5 C1253 959.5 1253 740 1253 716
5
false
18
101738
M1217 930 C1264 929 1253 804 1253 716
5
false
18
101739
M1304 923 C1244 920 1254 785 1253 716
5
false
18
101740
M1213 776 C1261 787 1254 837 1253 977
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
101741
M1253 716 C1254 767 1253 929 1253 977
5
false
18
true
M 25.946855044164835 13.26155629629604 L 11 12 L 17.380887721185843 25.575134323078345
false
101751
M319 1242 C349 1242 419 1241 449 1241
83
false
18
101752
M734 1242 C704 1242 629 1241 599 1241
83
false
18
true
M 153.6135217108315 264.9282229629627 L 138.66666666666666 263.6666666666667 L 145.0475543878525 277.241800989745
false
101753
M384 1292 C384 1237 398 1242 449 1241
83
false
18
101754
M684 1292 C685 1247 641 1242 599 1241
83
false
18
true
M 153.6135217108315 264.9282229629627 L 138.66666666666666 263.6666666666667 L 145.0475543878525 277.241800989745
false
3660785
M829 1237.5 C859 1237.5 886.5 1242.5 916.5 1242.5
5
true
18
3660786
M984 1184.5 L984 1234.5 L1034 1184.5 z
10
true
18
3660787
M919 1244 C891 1243 864 1242 834 1242
5
false
18
true
M 2437.9468550441647 3387.261556296296 L 2423 3386 L 2429.380887721186 3399.575134323078
false
3660796
M1203 1237.5 C1173 1237.5 1176 1232 1146 1232
5
true
18
3660797
M1148 1199 C1148 1239 1126 1243 1069 1244
5
false
18
3660798
M1133 1294 C1136 1263 1113 1244 1069 1244
5
false
18
3660799
M1069 1244 C1099 1244 1173 1244 1203 1244
5
false
18
true
M 3480.0096189432334 3880.5 L 3493 3873 L 3480.0096189432334 3865.5
false
20784
1859
2902
80760
71674
101735
Left
80761
71676
101736
Right
20785
1859
2903
80762
71676
101737
Left
80763
71677
101738
Left
80764
71678
101739
Left
80765
71679
101740
Right
80766
71680
101741
Right
797694
1859
179447
3224070
71687
3660785
Left
18645
803256
3660787
Right
797697
1859
179449
94
3224078
71674
3660796
Right
3224079
2679348
3660797
Right
3224080
2679349
3660798
Right
18647
803256
3660799
Left
969
514
1859
2373
71686
101751
Left
2374
71687
101752
Right
2375
71688
101753
Left
2376
71689
101754
Right
721
27574
443
186352
636
723
0.8
0.8
0
2
92
479
481
3625
M525 625 C525 575 575 525 625 525 C852 525 1146 525 1373 525 C1423 525 1473 575 1473 625 C1473 838 1473 1114 1473 1327 C1473 1377 1423 1427 1373 1427 C1146 1427 852 1427 625 1427 C575 1427 525 1377 525 1327 C525 1114 525 838 525 625
1
true
6
948.0
902.0
3626
M125 225 C125 175 175 125 225 125 C694 125 1304 125 1773 125 C1823 125 1873 175 1873 225 C1873 680 1873 1270 1873 1725 C1873 1775 1823 1825 1773 1825 C1304 1825 694 1825 225 1825 C175 1825 125 1775 125 1725 C125 1270 125 680 125 225
1
true
6
1748.0
1700.0