CHEBI:16136
ChEBI
cystathionine beta-lyase
454-29-5
CAS
cystathionine beta-lyase subunit 2
cystathionine beta-synthase
17215925
ChemSpider
6022
PubChem-compound
C2H4O2
Acetic acid
60.02113
Hydrogen sulfide
homoserine O-trans-acetylase
C23H38N7O17P3S
Acetyl-CoA
809.1258
O-acetylhomoserine (thiol)-lyase
Reaction2903
true
2-iminopropanoate + Hydrogen Ion + Water → Ammonium + Pyruvic acid
LEFT_TO_RIGHT
SMILES
N[C@@H](CS)C(O)=O
937
ChemSpider
22138-53-0
CAS
CYS
BioCyc
C05330
KEGG Compound
SMILES
N[C@@H](CCO)C(O)=O
18779926
PubChem-compound
64-19-7
CAS
57
ChemSpider
SMILES
O
P13663
UniProt
CHEBI:58020
ChEBI
Reaction6146
true
2-aminoprop-2-enoate → 2-iminopropanoate
LEFT_TO_RIGHT
Acetylhomoserine
1.0
HMDB0000099
HMDB
CHEBI:17115
ChEBI
P06106
UniProt
809
ChemSpider
C00441
KEGG Compound
HMDB0000538
HMDB
CHEBI:17230
ChEBI
ATP
BioCyc
SubPathwayInteraction111231
SubPathwayReaction
SubPathway111231Reaction
H4N
Ammonium
18.034374
1.0
ReactionCatalysis6229
ACTIVATION
6816
PubChem-compound
Pyruvic acid
ADP
BioCyc
C3H4O3
Pyruvic acid
88.016045
ReactionCatalysis6228
ACTIVATION
58
PubChem-compound
ReactionCatalysis6227
ACTIVATION
ReactionCatalysis6226
ACTIVATION
49791978
PubChem-compound
ReactionCatalysis6225
ACTIVATION
53-59-8
CAS
ReactionCatalysis6231
ACTIVATION
SMILES
NC(=C)C([O-])=O
ReactionCatalysis6230
ACTIVATION
1.0
5745
ChemSpider
1.0
5742
ChemSpider
1038
PubChem-compound
L-ASPARTATE
BioCyc
SMILES
CC(=N)C([O-])=O
CHEBI:17561
ChEBI
CHEBI:16474
ChEBI
P43623
UniProt
L-CYSTATHIONINE
BioCyc
1.0
ReactionCatalysis6233
ACTIVATION
391
ChemSpider
ReactionCatalysis6232
ACTIVATION
5736
ChemSpider
1.0
C00109
KEGG Compound
O4P
Phosphate
94.95342
Acetyl-CoA
NADPH
5862
PubChem-compound
P10869
UniProt
1010
ChemSpider
SER
BioCyc
Acetic acid
Saccharomyces cerevisiae
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS
600-18-0
CAS
NADP
C21H30N7O17P3
NADPH
745.0911
C21H29N7O17P3
NADP
744.08325
HMDB0003276
HMDB
1.0
NADPH
BioCyc
Ammonium
Hydrogen Ion
C3H4NO2
2-aminoprop-2-enoate
86.02475
672-15-1
CAS
218
ChemSpider
Adenosine triphosphate
C3H4NO2
2-iminopropanoate
86.02475
HMDB0000574
HMDB
HMDB0001423
HMDB
SMILES
[O-]P([O-])([O-])=O
C6H11NO4
Acetylhomoserine
161.0688
HMDB0000217
HMDB
C00009
KEGG Compound
C00008
KEGG Compound
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
HMDB0001429
HMDB
C00005
KEGG Compound
CHEBI:18367
ChEBI
2-OXOBUTANOATE
BioCyc
1032
ChemSpider
1031
ChemSpider
C00002
KEGG Compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
1.0
HMDB0000221
HMDB
1.0
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
C03082
KEGG Compound
2.3.1.31
false
2.3.1.31
Acetyl-CoA + L-Homoserine → Acetylhomoserine + Coenzyme A
LEFT_TO_RIGHT
cystathionine beta-lyase
O-acetylhomoserine (thiol)-lyase
2.5.1.49,2.5.1.47
false
2.5.1.49,2.5.1.47
Acetylhomoserine + Hydrogen sulfide → Acetic acid + Homocysteine + Hydrogen Ion
LEFT_TO_RIGHT
7783-06-4
CAS
4.4.1.8
false
4.4.1.8
Ammonium + Homocysteine + Pyruvic acid → L-Cystathionine + Water
LEFT_TO_RIGHT
cystathionine beta-synthase
cystathionine beta-lyase subunit 2
4.2.1.22
false
4.2.1.22
Homocysteine + L-Serine → L-Cystathionine + Water
LEFT_TO_RIGHT
HMDB0029423
HMDB
homoserine O-trans-acetylase
1.0
cystathionine gamma-lyase
53-57-6
CAS
1.0
aspartic beta semi-aldehyde dehydrogenase
Homoserine dehydrogenase
44367445
PubChem-compound
Cysteine Metabolism
CHEBI:17482
ChEBI
PW002383
PathWhiz
1.0
C01342
KEGG Compound
C00010
KEGG Compound
CHEBI:28938
ChEBI
5951
PubChem-compound
1.0
NAD(P)
BioCyc
HMDB0001206
HMDB
5957
PubChem-compound
SMILES
NC(CCS)C(O)=O
aspartokinase
12126
ChemSpider
H2S
Hydrogen sulfide
33.98772
H
Hydrogen Ion
1.007825
1.0
C00022
KEGG Compound
C00263
KEGG Compound
56-65-5
CAS
56-88-2
CAS
5653
ChemSpider
C00024
KEGG Compound
1.0
HMDB0000243
HMDB
SMILES
N[C@@H](CO)C(O)=O
Adenosine diphosphate
ACET
BioCyc
C10H15N5O10P2
Adenosine diphosphate
427.02942
L-Cystathionine
HMDB0000005
HMDB
SMILES
CCC(=O)C(O)=O
SMILES
N[C@@H](CC(O)=O)C(O)=O
SMILES
N[C@@H](CC=O)C(O)=O
SMILES
NC(CC(=O)OP(O)(O)=O)C(O)=O
C7H14N2O4S
L-Cystathionine
222.06743
1.0
SMP0002309
SMPDB
C00033
KEGG Compound
52-90-4
CAS
CPD-8587
BioCyc
L-Homoserine
CHEBI:30831
ChEBI
2.7.2.4
false
2.7.2.4
Adenosine triphosphate + L-Aspartic acid → Adenosine diphosphate + L-Aspartyl-4-phosphate
LEFT_TO_RIGHT
CHEBI:1146900
ChEBI
Reaction6305
false
L-Cysteine → 2-aminoprop-2-enoate + Hydrogen Ion + Hydrogen sulfide
LEFT_TO_RIGHT
Water
C00283
KEGG Compound
528
PubChem-compound
P32582
UniProt
P31373
UniProt
4.4.1.1
false
4.4.1.1
L-Cystathionine + Water → 2-Ketobutyric acid + Ammonium + L-Cysteine
LEFT_TO_RIGHT
Reaction6301
true
Acetylhomoserine + L-Cysteine → Acetic acid + Hydrogen Ion + L-Cystathionine
LEFT_TO_RIGHT
1.1.1.3
false
1.1.1.3
Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP
LEFT_TO_RIGHT
1.2.1.11
false
1.2.1.11
Hydrogen Ion + L-Aspartyl-4-phosphate + NADPH → L-Aspartate-semialdehyde + NADP + Phosphate
LEFT_TO_RIGHT
HMDB0001341
HMDB
CHEBI:15699
ChEBI
HMDB0012249
HMDB
CO-A
BioCyc
5675
ChemSpider
72-89-9
CAS
SMILES
S
C00049
KEGG Compound
L-Cysteine
Coenzyme A
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
C21H36N7O16P3S
Coenzyme A
767.11523
14798-03-9
CAS
SMILES
N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
CHEBI:15422
ChEBI
6557
ChemSpider
SMILES
CC(O)=O
12647
PubChem-compound
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
HMDB0012250
HMDB
1.0
7732-18-5
CAS
127-17-3
CAS
L-BETA-ASPARTYL-P
BioCyc
2-iminopropanoate
cystathionine beta-lyase
1.0
SMILES
[NH4+]
C10H16N5O13P3
Adenosine triphosphate
506.99576
1.0
CHEBI:17053
ChEBI
C00065
KEGG Compound
2-aminoprop-2-enoate
CHEBI:16761
ChEBI
HMDB0000719
HMDB
SMILES
CC(=O)C(O)=O
1.0
1.0
HMDB0000042
HMDB
Endocytosis
SubPathway
CHEBI:15366
ChEBI
962
PubChem-compound
392413
ChemSpider
5800
ChemSpider
388392
ChemSpider
Phosphate
1.0
439235
PubChem-compound
C00080
KEGG Compound
CHEBI:77456
ChEBI
7540-67-2
CAS
171
ChemSpider
CHEBI:32816
ChEBI
HMDB0002111
HMDB
15106-57-7
CAS
C4H9NO2S
Homocysteine
135.0354
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
14265-44-2
CAS
PYRUVATE
BioCyc
832
PubChem-compound
58-64-0
CAS
56-45-1
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
2-Ketobutyric acid
CHEBI:7671
ChEBI
HOMO-CYS
BioCyc
1.0
1.0
C4H8NO7P
L-Aspartyl-4-phosphate
213.00385
L-Aspartic acid
HMDB0000742
HMDB
L-Aspartate-semialdehyde
L-Serine
L-Aspartyl-4-phosphate
C4H6O3
2-Ketobutyric acid
102.03169
C4H7NO4
L-Aspartic acid
133.0375
C3H7NO3
L-Serine
105.042595
C4H7NO3
L-Aspartate-semialdehyde
117.042595
HMDB0000187
HMDB
P53101
UniProt
C3H7NO2S
L-Cysteine
121.01975
4932
TAXONOMY
444493
PubChem-compound
P31116
UniProt
16741146
PubChem-compound
25243997
PubChem-compound
388372
ChemSpider
C00097
KEGG Compound
757
ChemSpider
L-ASPARTATE-SEMIALDEHYDE
BioCyc
513
ChemSpider
HS
BioCyc
22833512
PubChem-compound
HOMO-SER
BioCyc
Homocysteine
ACETYL-COA
BioCyc
H2O
Water
18.010565
CHEBI:18051
ChEBI
HMDB0000191
HMDB
SMILES
CC(=O)OCCC(N)C(O)=O
C4H9NO3
L-Homoserine
119.05824
1060
PubChem-compound
1061
PubChem-compound
P08465
UniProt
HMDB0059597
HMDB
HMDB0041827
HMDB
cystathionine gamma-lyase
Homoserine dehydrogenase
56-84-8
CAS
aspartic beta semi-aldehyde dehydrogenase
aspartokinase
CHEBI:15351
ChEBI
176
PubChem-compound
C02291
KEGG Compound
85-61-0
CAS