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Malate synthase 1, glyoxysomal malate synthase 2 Malate dehydrogenase, cytoplasmic citrate synthase aconitate hydratase aconitate hydratase Isocitrate lyase Glyoxylic acid Acetyl-CoA H 2 O CoA H + L-Malic acid NAD H + NADH Oxalacetic acid Acetyl-CoA H 2 O CoA H + Citric acid H 2 O cis-Aconitic acid H 2 O D-threo- Isocitric acid Succinic acid Glyoxylic acid
MLS1 DAL7 MDH2 CIT2 ACO1 ACO1 ICL1 Glyoxylic acid Acetyl-CoA Water Coenzyme A Hydrogen Ion L-Malic acid NAD Hydrogen Ion NADH Oxalacetic acid Acetyl-CoA Water Coenzyme A Hydrogen Ion Citric acid Water cis-Aconitic acid Water D-threo- Isocitric acid Succinic acid Glyoxylic acid