3-ketoacyl-CoA
synthase ELO1
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
Acyl-CoA
synthase
3-oxoacyl-
[acyl- carrier-
protein]
reductase
Peroxisomal
hydratase-
dehydrogenase-
epimerase
dihydrosphingosine
C-4 hydroxylase
3-
ketosphinganine
reductase
Ceramide
synthase
subunit LIP1
Serine
palmitoyltransferase
1
2-enoyl
thioester
reductase
Palmityl-CoA
Malonyl-CoA
H+
CO2
3-
Oxooctadecanoyl-
CoA
CoA
Palmitic acid
ATP
CoA
AMP
PPi
H+
NADPH
NADP
(3R)-3-
hydroxy-
stearoyl-CoA
(2E)-
Octadecenoyl-
CoA
H2O
H+
O2
Sphinganine
H2O
Phytosphingosine
H+
NADPH
3-
Dehydrosphinganine
NADP
Stearoyl-CoA
CoA
H+
N-
stearoylphytosphingosine
Palmityl-CoA
L-Serine
CO2
H+
NADPH
NADP
ferrocytochrome
b5
ferricytochrome
b5