CHEBI:16015
ChEBI
30572
ChemSpider
17215925
ChemSpider
937
ChemSpider
57
ChemSpider
SMILES
O
50
ChemSpider
1.0
73-32-5
CAS
PW002476
PathWhiz
H4N
Ammonium
18.034374
1.0
51
PubChem-compound
46
ChemSpider
Pyruvic acid
Unknown
19796801
PubChem-compound
58
PubChem-compound
C3H4O3
Pyruvic acid
88.016045
6288
PubChem-compound
562-43-6
CAS
53-59-8
CAS
Reaction2924
true
2-iminobutanoate + Hydrogen Ion + Water → 2-Ketobutyric acid + Ammonium
LEFT_TO_RIGHT
THR
BioCyc
1038
PubChem-compound
CHEBI:16474
ChEBI
274
ChemSpider
Reaction2923
true
(2Z)-2-aminobut-2-enoate → 2-iminobutanoate
LEFT_TO_RIGHT
C5H6O5
Oxoglutaric acid
146.02153
C6H10O3
3-Methyl-2-oxovaleric acid
130.06299
4.0
2-dehydropantoate 2-reductase
C00109
KEGG Compound
NADPH
SMILES
CC=C(N)C([O-])=O
1010
ChemSpider
SMP0121161
SMPDB
Saccharomyces cerevisiae
C6H12O4
(R) 2,3-Dihydroxy-3-methylvalerate
148.07356
(R) 2,3-Dihydroxy-3-methylvalerate
2.0
600-18-0
CAS
NADP
C21H30N7O17P3
NADPH
745.0911
C21H29N7O17P3
NADP
744.08325
1.0
NADPH
BioCyc
Ammonium
Threo-3-hydroxyaspartate ammonia-lyase
CHEBI:16857
ChEBI
Hydrogen Ion
Pyruvate decarboxylase isozyme 3
HMDB0000208
HMDB
218
ChemSpider
P26263
UniProt
(S)-2-Aceto-2-hydroxybutanoic acid
SMILES
CCC(C)C(=O)C(O)=O
72-19-5
CAS
L-Glutamic acid
CHEBI:27512
ChEBI
1.0
HMDB0000217
HMDB
SMILES
OC(=O)CCC(=O)C(O)=O
124-38-9
CAS
CHEBI:30915
ChEBI
Reaction5890
true
3-Methyl-2-oxovaleric acid ↔ 2-Keto-3-methyl-valerate
REVERSIBLE
1.0
1.0
6.0
2-iminobutanoate
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
1460-34-0
CAS
C00005
KEGG Compound
2-OXOBUTANOATE
BioCyc
C4H6NO2
(2Z)-2-aminobut-2-enoate
100.040405
1031
ChemSpider
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
6051
ChemSpider
(2Z)-2-aminobut-2-enoate
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
SMILES
CC[C@@](C)(O)[C@@H](O)C(O)=O
GLT
BioCyc
53-57-6
CAS
Dihydroxy-acid dehydratase, mitochondrial
C4H6NO2
2-iminobutanoate
100.040405
1.0
C01342
KEGG Compound
C00011
KEGG Compound
SMILES
O=C=O
CHEBI:28938
ChEBI
SMILES
C[C@@H](O)[C@H](N)C(O)=O
4.3.1.19
false
4.3.1.19
L-Threonine → (2Z)-2-aminobut-2-enoate + Hydrogen Ion + Water
LEFT_TO_RIGHT
NAD(P)
BioCyc
SMILES
CC[C@H](C)[C@H](N)C(O)=O
47
PubChem-compound
H
Hydrogen Ion
1.007825
1.0
C00022
KEGG Compound
Threonine Biosynthesis
SubPathway
C06006
KEGG Compound
6067
ChemSpider
C06007
KEGG Compound
C00026
KEGG Compound
440875
PubChem-compound
C00025
KEGG Compound
HMDB0000243
HMDB
HMDB0000005
HMDB
SMILES
CCC(=O)C(O)=O
HMDB0006900
HMDB
1.0
SMP0002375
SMPDB
1-KETO-2-METHYLVALERATE
BioCyc
448154
PubChem-compound
6306
PubChem-compound
2.0
CHEBI:30831
ChEBI
ReactionCatalysis6738
ACTIVATION
328-50-7
CAS
ReactionCatalysis6737
ACTIVATION
Water
ReactionCatalysis6736
ACTIVATION
ReactionCatalysis6735
ACTIVATION
1.0
ReactionCatalysis6739
ACTIVATION
HMDB0000491
HMDB
ReactionCatalysis6734
ACTIVATION
395044
ChemSpider
dihydroxy acid dehydratase, mitochondrial
5675
ChemSpider
ILE
BioCyc
acetohydroxy acid isomeroreductase
14798-03-9
CAS
HMDB0000148
HMDB
CHEBI:58739
ChEBI
CHEBI:17191
ChEBI
2.2.1.6
false
2.2.1.6
2-Ketobutyric acid + Hydrogen Ion + Pyruvic acid → (S)-2-Aceto-2-hydroxybutanoic acid + Carbon dioxide
LEFT_TO_RIGHT
ReactionCatalysis6740
ACTIVATION
Reaction6771
false
(S)-2-Aceto-2-hydroxybutanoic acid + Hydrogen Ion + NADPH → (R) 2,3-Dihydroxy-3-methylvalerate + NADP
LEFT_TO_RIGHT
P39522
UniProt
Reaction6772
false
(R) 2,3-Dihydroxy-3-methylvalerate → 3-Methyl-2-oxovaleric acid + Water
LEFT_TO_RIGHT
Threo-3-hydroxyaspartate ammonia-lyase
Reaction6773
false
3-Methyl-2-oxovaleric acid + L-Glutamic acid → L-Isoleucine + Oxoglutaric acid
LEFT_TO_RIGHT
Pyruvate decarboxylase isozyme 3
4.0
2-dehydropantoate 2-reductase
7732-18-5
CAS
1.0
C6H10O4
(S)-2-Aceto-2-hydroxybutanoic acid
146.0579
127-17-3
CAS
1.0
56-86-0
CAS
389708
ChemSpider
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
SMILES
[NH4+]
6857401
PubChem-compound
CHEBI:16526
ChEBI
C00188
KEGG Compound
HMDB0012140
HMDB
1.0
CHEBI:35146
ChEBI
HMDB0000167
HMDB
SMILES
CC(=O)C(O)=O
1.0
CHEBI:35932
ChEBI
SMILES
CC[C@H](C)C(=O)C([O-])=O
962
PubChem-compound
C4H9NO3
L-Threonine
119.05824
2-KETOGLUTARATE
BioCyc
SMILES
CCC(=N)C([O-])=O
2-KETO-3-METHYL-VALERATE
BioCyc
Unknown
CO2
Carbon dioxide
43.98983
C03465
KEGG Compound
2.0
C00080
KEGG Compound
Oxoglutaric acid
SMILES
CC[C@](O)(C(C)=O)C(O)=O
3-Methyl-2-oxovaleric acid
C6H13NO2
L-Isoleucine
131.09464
HMDB0000172
HMDB
HMDB0002111
HMDB
1.0
CHEBI:32816
ChEBI
SMILES
N[C@@H](CCC(O)=O)C(O)=O
Isoleucine Biosynthesis
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
PYRUVATE
BioCyc
2-Keto-3-methyl-valerate
C00407
KEGG Compound
5886
PubChem-compound
2-Ketobutyric acid
SubPathwayInteraction110064
SubPathway110064Reaction
SubPathwayReaction
1.0
1.0
acetohydroxybutanoate synthase / acetolactate synthase
280
PubChem-compound
C4H6O3
2-Ketobutyric acid
102.03169
C6H9O3
2-Keto-3-methyl-valerate
129.05518
4932
TAXONOMY
P36007
UniProt
16741146
PubChem-compound
22833512
PubChem-compound
acetolactate synthase / acetohydroxybutanoate synthase 3
threonine deaminase
L-Isoleucine
H2O
Water
18.010565
acetohydroxybutanoate synthase / acetolactate synthase 2
branched-chain amino-acid aminotransferase
P38787
UniProt
1.0
1060
PubChem-compound
HMDB0059597
HMDB
HMDB0041827
HMDB
Carbon dioxide
HMDB0001967
HMDB
L-Threonine
SubPathwayOutput
PW122449
PathWhiz
Dihydroxy-acid dehydratase, mitochondrial
CHEBI:27681
ChEBI