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3-oxo-5-alpha- steroid 4-dehydrogenase 1 Aldo-keto reductase family 1 member C4 UDP- glucuronosyltransferase 1-1 Cytochrome P450 19A1 Cytochrome P450 19A1 Cytochrome P450 19A1 Testosterone 17-beta- dehydrogenase 3 Cytochrome P450 11B1, mitochondrial 3-oxo-5-beta- steroid 4-dehydrogenase UDP- glucuronosyltransferase 1-1 Corticosteroid 11-beta- dehydrogenase isozyme 1 Aldo-keto reductase family 1 member C4 11b- Hydroxyandrost- 4-ene-3,17- dione 11b- Hydroxyandrost- 4-ene-3,17- dione Androstenedione NADPH H+ Androstanedione NADP NADH H+ Androsterone NAD Uridine diphosphate glucuronic acid Androsterone glucuronide Uridine 5'-diphosphate O2 19- Hydroxyandrost- 4-ene-3,17- dione H2O O2 19-Oxoandrost- 4-ene-3,17- dione H2O O2 Estrone Formic acid H2O Testosterone NAD NADH H+ O2 H+ H2O NADPH H+ NADP Etiocholanedione Etiocholanolone Uridine diphosphate glucuronic acid Etiocholanolone glucuronide Uridine 5'-diphosphate NADP NADPH H+ Adrenosterone NADH H+ NAD Heme Reduced flavoprotein Oxidized flavoprotein Reduced flavoprotein Oxidized flavoprotein Reduced flavoprotein Oxidized flavoprotein Reduced adrenal ferredoxin Oxidized adrenal ferredoxin Heme Heme Heme Endoplasmic Reticulum Membrane Cytosol
SRD5A1 AKR1C4 ERP29 CYP19A1 CYP19A1 CYP19A1 HSD17B3 CYP11B1 AKR1D1 ERP29 HSD11B1 AKR1C4 4AO3D 4AO3D Adione NADPH H+ Androst NADP NADH H+ Androtn NAD UDPGlcA AGlcA UDP O2 19-Haon H2O O2 19O4e H2O O2 Estrone Formate H2O Oreton NAD NADH H+ O2 H+ H2O NADPH H+ NADP Etiocon Etiocho UDPGlcA Etiocho UDP NADP NADPH H+ Adreno NADH H+ NAD Heme RF OF RF OF RF OF RAF OAF Heme Heme Heme Endoplasmic Reticulum Membrane Cytosol
Endoplasmic Reticulum SRD5A1 AKR1C4 ERP29 CYP19A1 CYP19A1 CYP19A1 HSD17B3 CYP11B1 AKR1D1 ERP29 HSD11B1 AKR1C4 4AO3D 4AO3D Adione NADPH H+ Androst NADP NADH H+ Androtn NAD UDPGlcA AGlcA UDP O2 19-Haon H2O O2 19O4e H2O O2 Estrone Formate H2O Oreton NAD NADH H+ O2 H+ H2O NADPH H+ NADP Etiocon Etiocho UDPGlcA Etiocho UDP NADP NADPH H+ Adreno NADH H+ NAD RF OF RF OF RF OF RAF OAF