RELA
1.0
1.0
17215925
ChemSpider
446013
PubChem-compound
Monocyte differentiation antigen CD14
C23H38N7O17P3S
Acetyl-CoA
809.1258
Q7TQN4
UniProt
Reaction147997
false
Acetyl-CoA → Malonyl-CoA
LEFT_TO_RIGHT
Toll-like receptor 4
31348
PubChem-compound
TNF receptor-associated factor 6
direct_interaction
NF-kappa-B inhibitor alpha
1.0
1.0
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
LPS Receptor Complex
1.0
Succinate dehydrogenase complex subunit C
NF-kappa-B inhibitor alpha
LPS and Citrate Signaling and Inflammation
C4H4O5
2-Hydroxybutanedioate
132.00697
H
Hydrogen ion
1.007825
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
C205H366N3O117P5
Lipopolysaccharide
4897.147
C4H2O5
2-Oxobutanedioate
129.99022
1.0
C6H5O7
Citrate
189.00352
TransportCatalysis1453
ACTIVATION
C23H38N7O17P3S
Acetyl Coenzyme A
809.1258
NF-kappa-B essential modulator
ReactionCatalysis169032
ACTIVATION
ReactionCatalysis169031
ACTIVATION
Transport10273
false
Citrate (→) Transport: Rattus norvegicus, Cell, Mitochondrial Inner Membrane to Rattus norvegicus, Cell, Mitochondrial Outer Membrane
LEFT_TO_RIGHT
1.0
Q641Z9
UniProt
TNF receptor-associated factor 6
HMDB0001197
HMDB
C3H4O3
Pyruvic acid
88.016045
Reaction179128
false
Citrate → 2-Oxobutanedioate
LEFT_TO_RIGHT
Reaction179127
false
Citrate → Acetyl-CoA
LEFT_TO_RIGHT
Reaction179126
false
FAD → FADH
LEFT_TO_RIGHT
Reaction179125
false
2-Oxobutanedioate + Acetyl Coenzyme A → Citrate
LEFT_TO_RIGHT
53-59-8
CAS
CHEBI:16238
ChEBI
Q920L2
UniProt
ReactionCatalysis169029
ACTIVATION
Reaction179129
false
2-Oxobutanedioate → 2-Hydroxybutanedioate
LEFT_TO_RIGHT
ReactionCatalysis169028
ACTIVATION
ReactionCatalysis169027
ACTIVATION
Citrate
NF-kappa-B essential modulator
CHEBI:16474
ChEBI
MD2
Tricarboxylate transport protein, mitochondrial
393487
ChemSpider
NADP-dependent malic enzyme
2.0
C27H35N9O15P2
FADH
787.1728
P13697
UniProt
MD2
1.0
Rattus norvegicus
C21H30N7O17P3
NADPH
745.0911
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Fatty Acid
Mitochondrion
C21H29N7O17P3
NADP
744.08325
Acetyl-CoA
NADPH
BioCyc
Q6PCV2
UniProt
Q63736
UniProt
MD2
SMILES
[O-]C(=O)CC(=O)C([O-])=O
1.0
HMDB0000217
HMDB
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
Malate dehydrogenase, cytoplasmic
SMILES
OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
Monocyte differentiation antigen CD14
Q6GT04
UniProt
SMILES
OC(CC([O-])=O)C([O-])=O
SMILES
CCCCCCCCCCCCCCCC1[C@@H](CP(O)(O)=O)OC(CO[C@@H]2OC(CO[C@@]3(CC(O[C@@]4(CC(O[C@@]5(CC(O)[C@@H](O)C(O5)C(O)CO)C(O)=O)[C@@H](O)C(O4)C(O)CO)C(O)=O)[C@@H](O[C@@H]4OC(C(O)CO)[C@@H](OP(O)(=O)OP(O)(=O)OCCN)C(O[C@H]5OC(C(O)CO[C@H]6OC[C@](O)(C(O)CO)C(O)[C@H]6O)[C@@H](OP(O)(O)=O)C(O[C@H]6OC(CO[C@H]7OC(CO)[C@H](O)C(O)C7O)[C@@H](O)C(O[C@H]7OC(CO)[C@H](O)C(O)C7O[C@H]7OC(CO)[C@@H](O[C@H]8OC(CO)[C@H](O)C(OC9O[C@@H](C)C(O[C@H]%10OC(CO)[C@@H](O)C(O[C@H]%11OC(C)[C@H](O)CC%11O)C%10O[C@H]%10OC(CO)[C@H](O)C(O)C%10O)C(O)[C@H]9O)C8O)C(O)C7O[C@H]7OC(CO)[C@@H](O)C(O)[C@@H]7NC(C)=O)C6O)[C@H]5O)[C@H]4O)C(O3)C(O)CO)C(O)=O)[C@@H](OP(O)(O)=O)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H]2NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H](O)[C@@H]1OC(=O)CC(O)CCCCCCCCCCC
Citrate synthase, mitochondrial
CHEBI:15531
ChEBI
C00006
KEGG Compound
CHEBI:18009
ChEBI
559059
ChemSpider
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1
Reaction179131
false
NADPH → NADP
LEFT_TO_RIGHT
Reaction179130
false
2-Hydroxybutanedioate → Pyruvic acid
LEFT_TO_RIGHT
C00005
KEGG Compound
1910-41-4
CAS
CHEBI:35366
ChEBI
1031
ChemSpider
NADP
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
Mitochondrial Inner Membrane
GO:0005634
GENE ONTOLOGY
2-Hydroxybutanedioate
53-57-6
CAS
C27H33N9O15P2
FAD
785.1571
C00016
KEGG Compound
FAD
Extracellular Space
Acetyl Coenzyme A
164550
PubChem-compound
NAD(P)
BioCyc
HMDB0001206
HMDB
GO:0005743
GENE ONTOLOGY
GO:0005741
GENE ONTOLOGY
FADH
1.0
Pyruvic acid
RELA
Inhibitor of nuclear factor kappa-B kinase subunit beta
Malonyl-CoA
C00022
KEGG Compound
C01352
KEGG Compound
C00024
KEGG Compound
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
B5DF45
UniProt
HMDB0000243
HMDB
CHUK-IKBKB-IKBKG complex
GO:0005739
GENE ONTOLOGY
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
Q8VHF5
UniProt
RCG22794, isoform CRA_a
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
ATP-citrate synthase
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
2-Oxobutanedioate
Mitochondrial Outer Membrane
NADP-dependent malic enzyme
Hydrogen ion
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
10116
TAXONOMY
1.0
Q56DL5
UniProt
Interaction2813
Citrate inhibits 6-phosphofructokinase, muscle type
Interaction2814
Citrate inhibits Succinate dehydrogenase
Interaction2815
Lipopolysaccharide activates LPS Receptor Complex
Interaction2816
Myeloid differentiation primary response protein MyD88 (Rattus norvegicus) + Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus) + TNF receptor-associated factor 6 (Rattus norvegicus) activates LPS Receptor Complex
Q9QY78
UniProt
1.0
NFKB1,NFKBIA,RELA Complex with Phosphate
B2RYS5
UniProt
Acetyl-CoA carboxylase 1
Citrate
ReactionCatalysis138263
ACTIVATION
Interaction2817
LPS Receptor Complex activates CHUK-IKBKB-IKBKG complex
1.0
Interaction2818
CHUK-IKBKB-IKBKG complex activates NFKB1,NFKBIA,RELA Complex with Phosphate
Toll-like receptor 4
RELA
Interaction2819
NFKB1,NFKBIA,RELA Complex with Phosphate activates Nuclear factor NF-kappa-B p105 subunit
Citrate
Lipopolysaccharide
1.0
CHEBI:17877
ChEBI
5675
ChemSpider
72-89-9
CAS
ATP-dependent 6-phosphofructokinase, muscle type
1.0
Reaction164136
false
Malonyl-CoA → Fatty Acid
LEFT_TO_RIGHT
Q0QEZ3
UniProt
4.0
Cytoplasm
ATP-citrate synthase
1.0
4.0
NADPH
10213
ChemSpider
1.0
643975
PubChem-compound
Succinate dehydrogenase
160434
PubChem-compound
Q6PCT8
UniProt
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
524-14-1
CAS
2-Oxobutanedioate
Citrate synthase, mitochondrial
1.0
127-17-3
CAS
HMDB0001248
HMDB
1.0
Nuclear factor NF-kappa-B p105 subunit
Reaction164141
false
Pyruvic acid → Hydrogen ion + NADPH
LEFT_TO_RIGHT
Reaction164142
false
NADP → Pyruvic acid
LEFT_TO_RIGHT
Toll-like receptor 4
1.0
Q498T8
UniProt
SMILES
CC(=O)C(O)=O
Tricarboxylate transport protein, mitochondrial
1.0
392413
ChemSpider
Q8VIQ1
UniProt
Fatty Acid
Q9QX05
UniProt
1.0
P97902
UniProt
Myeloid differentiation primary response protein MyD88
Myeloid differentiation primary response protein MyD88
RCG22794, isoform CRA_a
1.0
C00083
KEGG Compound
Malate dehydrogenase, cytoplasmic
CHEBI:32816
ChEBI
146-14-5
CAS
C24H38N7O19P3S
Malonyl-CoA
853.1156
NFKB1,NFKBIA,RELA Complex with Phosphate
PYRUVATE
BioCyc
SMP0120970
SMPDB
5886
PubChem-compound
NADP-dependent malic enzyme
PW122233
PathWhiz
Nuclear factor NF-kappa-B p105 subunit
LPS Receptor Complex
1.0
Inhibitor of nuclear factor kappa-B kinase subunit beta
1.0
Citrate synthase, mitochondrial
D3ZXA5
UniProt
444493
PubChem-compound
10663
PubChem-compound
22833512
PubChem-compound
ACETYL-COA
BioCyc
ATP-citrate synthase
Acetyl-CoA carboxylase 1
FAD
BioCyc
NF-kappa-B inhibitor alpha
FADH2
BioCyc
Nucleus
Nuclear factor NF-kappa-B p105 subunit
1060
PubChem-compound
SMILES
[H+]
1.0
Q63369
UniProt
CHEBI:15351
ChEBI
Succinate dehydrogenase complex subunit C
11970143
PubChem-compound
ATP-dependent 6-phosphofructokinase, muscle type
Myeloid differentiation primary response protein MyD88 (Rattus norvegicus)_Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus)_TNF receptor-associated factor 6 (Rattus norvegicus)
Monocyte differentiation antigen CD14
Q6TMG5
UniProt
MALONYL-COA
BioCyc
Q4QRC0
UniProt
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
HMDB0001175
HMDB
Citrate