Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Solute carrier
family 22
member 11
Solute carrier
family 22
member 6
Solute carrier
family 22
member 8
Solute carrier
organic anion
transporter
family member
2B1
Multidrug
resistance-
associated
protein 4
Multidrug
resistance-
associated
protein 5
Leukotriene-
B(4) omega-
hydroxylase 1
Leukotriene
A-4 hydrolase
Leukotriene C4
synthase
Gamma-
glutamyltranspeptidase
1
Glutathione
peroxidase 1
Prostacyclin
synthase
Prostaglandin-
H2 D-isomerase
Aldo-keto
reductase
family 1
member C3
Thromboxane-A
synthase
Prostaglandin
E synthase
Prostamide/prostaglandin
F synthase
Carbonyl
reductase
[NADPH] 1
Arachidonate
15-lipoxygenase
Cytochrome
P450 2C8
Cytochrome
P450 2C8
Cytochrome
P450 2C8
Cytochrome
P450 2C8
Cytochrome
P450 2C8
Cytochrome
P450 2B6
Epoxide
hydratase 2
Cytochrome
P450 2B6
Epoxide
hydratase 2
Arachidonate
5-lipoxygenase
Arachidonate
5-lipoxygenase
Glutathione
peroxidase 1
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
Cytochrome
P450 2B6
Epoxide
hydratase 2
Cytochrome
P450 2B6
Epoxide
hydratase 2
Arachidonate
15-lipoxygenase
B
Cytochrome
P450 2E1
Arachidonate
12-
lipoxygenase,
12R-type
Cytochrome
P450 2J2
Cytochrome
P450 2U1
Cytochrome
P450 4A11
Cytochrome
P450 2U1
Arachidonate
12-
lipoxygenase,
12S-type
Cytosolic
phospholipase
A2 beta
Cytochrome
P450 4F8
Leukotriene-
B(4) omega-
hydroxylase 2
Piroxicam
Piroxicam
Prostaglandin H2
Prostaglandin H2
20-Hydroxy-leukotriene B4
20-Carboxy-leukotriene B4
Leukotriene B4
NADPH
O
2
NADP
H
2
O
Leukotriene A4
H
2
O
12-Keto-leukotriene B4
Glutathione
Leukotriene C4
H
2
O
Leukotriene D4
L-Glutamic
acid
5,6-Epoxytetraene
15(S)-HPETE
Glutathione
15(S)-HETE
Oxidized glutathione
H
2
O
δ-12-Prostaglandin J2
15-Deoxy-d-12,14-PGJ2
6-Keto-prostaglandin F1a
6-Ketoprostaglandin E1
5-HETE
5-KETE
Prostaglandin J2
Prostaglandin I2
Prostaglandin D2
NADPH
11-Epi-PGF2a
NADP
Thromboxane A2
Prostaglandin E2
Prostaglandin F2a
NADPH
NADP
Prostaglandin A2
Prostaglandin-c2
Thromboxane B2
Prostaglandin B2
11-Dehydro-thromboxane B2
Arachidonic acid
O
2
O
2
11H-14,15-EETA
H
2
O
O
2
11,14,15-THETA
H
2
O
O
2
15H-11,12-EETA
H
2
O
O
2
11,12,15-THETA
H
2
O
O
2
16(R)-HETE
H
2
O
O
2
14,15-Epoxy-5,8,11-
eicosatrienoic acid
H
2
O
H
2
O
14,15-DiHETrE
O
2
11,12-Epoxyeicosatrienoic acid
H
2
O
H
2
O
11,12-DiHETrE
5-HPETE
O
2
H
2
O
O
2
H
2
O
Glutathione
Oxidized glutathione
H
2
O
Prostaglandin G2
H
2
O
O
2
O
2
8,9-Epoxyeicosatrienoic acid
H
2
O
H
2
O
8,9-DiHETrE
O
2
5,6-Epoxy-8,11,14-
eicosatrienoic acid
H
2
O
H
2
O
5,6-DHET
O
2
8(S)-HPETE
O
2
19(S)-HETE
H
2
O
O
2
12(R)-HPETE
8-HETE
Arachidonic acid
8-Isoprostane
O
2
H
2
O
O
2
H
2
O
O
2
20-Hydroxyeicosatetraenoic
acid
H
2
O
O
2
H
2
O
O
2
12(S)-HPETE
12(R)-HETE
12-KETE
12(S)-HETE
PC(14:0/20:4(5Z,8Z,11Z,14Z))
H
2
O
LysoPC(14:0/0:0)
NADPH
O
2
NADP
H
2
O
2,3-Dinor-8iso prostaglandin
F1α
2,3-Dinor-8iso prostaglandin
F2α
Heme
Heme
Heme
Zinc (II) ion
Heme
Heme
Glutathione
Fe3+
Heme
Heme
Heme
Heme
Heme
Heme
Magnesium
Heme
Magnesium
Fe3+
Calcium
Fe3+
Calcium
Heme
Heme
Heme
Magnesium
Heme
Magnesium
Fe3+
Heme
Fe3+
Heme
Heme
Heme
Heme
Fe3+
Calcium
Heme
Heme
Cytosol
Lumen
Lumen
Cytosol
Lumen
Cytosol
Lumen
Cytosol
Lumen
Extracellular Space
Intracellular Space