1.0
17215925
ChemSpider
1.0
937
ChemSpider
P48775
UniProt
SMILES
OC(=O)C1=CC(=O)C2=CC=CC=C2N1
SMILES
O
16597-58-3
CAS
1.0
C7H5NO4
Quinolinic acid
167.02185
492-27-3
CAS
C00328
KEGG Compound
4444266
ChemSpider
Trypto
C7H7NO2
Anthranilic Acid
137.04768
910
PubChem-compound
SMILES
NC(CC(=O)C1=C(N)C(O)=CC=C1)C(O)=O
Water
25244175
PubChem-compound
53-59-8
CAS
BTO:0000759
BRENDA TISSUE ONTOLOGY
Kynureninase
C03722
KEGG Compound
CHEBI:16474
ChEBI
952
ChemSpider
L-3-Hydroxykynurenine
278
ChemSpider
CHEBI:995
ChEBI
86
PubChem-compound
C11H12N2O4
N'-Formylkynurenine
236.07971
C02406
KEGG Compound
HMDB0000684
HMDB
ReactionCatalysis1357
ACTIVATION
Kynurenic acid
73-22-3
CAS
Kynurenine--oxoglutarate transaminase 3
C10H12N2O4
L-3-Hydroxykynurenine
224.07971
C21H30N7O17P3
NADPH
745.0911
ReactionCatalysis1351
ACTIVATION
C21H29N7O17P3
NADP
744.08325
ReactionCatalysis1353
ACTIVATION
NADPH
BioCyc
1.0
C11H12N2O2
L-Tryptophan
204.08987
1.14.13.9
false
1.14.13.9
L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
LEFT_TO_RIGHT
3-HYDROXY-ANTHRANILATE
BioCyc
11811
PubChem-compound
CPD-6641
BioCyc
2.0
CHEBI:17380
ChEBI
1.0
HMDB0000217
HMDB
Anthranilic Acid
3.5.1.9
false
3.5.1.9
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
LEFT_TO_RIGHT
SMILES
NC1=CC=CC=C1C(O)=O
1037
ChemSpider
C00007
KEGG Compound
1.13.11.11
false
1.13.11.11
L-Tryptophan + Oxygen → N'-Formylkynurenine
LEFT_TO_RIGHT
C00006
KEGG Compound
1.0
CHEBI:18009
ChEBI
C00001
KEGG Compound
Tryptophan 2,3-dioxygenase
C00005
KEGG Compound
Quinolinic acid
SMILES
NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O
548-93-6
CAS
Liver
NADP
SMILES
N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
5280673
PubChem-compound
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
87
ChemSpider
84
ChemSpider
1.0
Oxygen
53-57-6
CAS
227
PubChem-compound
C7H7NO3
3-Hydroxyanthranilic acid
153.04259
161166
PubChem-compound
C02794
KEGG Compound
HMDB0001200
HMDB
HMDB0000232
HMDB
QUINOLINATE
BioCyc
NAD(P)
BioCyc
1.0
C7H7NO5
2-Amino-3-carboxymuconic acid semialdehyde
185.03242
CHEBI:16946
ChEBI
CHEBI:16828
ChEBI
Kynurenine formamidase
CHEBI:18344
ChEBI
6066
ChemSpider
Kynurenine 3-monooxygenase
GO:0005737
GENE ONTOLOGY
PW122293
PathWhiz
1.0
Reaction1622
false
2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
LEFT_TO_RIGHT
1.13.11.6
false
1.13.11.6
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
LEFT_TO_RIGHT
1022-31-7
CAS
HMDB0001330
HMDB
L-Kynurenine
6305
PubChem-compound
ReactionCatalysis154508
ACTIVATION
HMDB0000929
HMDB
3-Hydroxyanthranilic acid
Kynurenine--oxoglutarate transaminase 3
SMILES
N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O
ReactionCatalysis154510
ACTIVATION
C04409
KEGG Compound
Kynureninase
Kynurenine 3-monooxygenase
5675
ChemSpider
886
ChemSpider
HMDB0001476
HMDB
SMILES
N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O
BiologicalState393
Liver
18971002
PubChem-compound
Cytoplasm
Q16719
UniProt
2-AMINO-3-CARBOXYMUCONATE_SEMIAL
BioCyc
484-78-6
CAS
TRP
BioCyc
3,4-Dihydroxyphenylacetaldehyde
NADPH
HMDB0000142
HMDB
1.0
Homo sapiens
CHEBI:18377
ChEBI
7732-18-5
CAS
Q6YP21
UniProt
C00058
KEGG Compound
89-00-9
CAS
Reaction164146
false
L-Kynurenine → Kynurenic acid
LEFT_TO_RIGHT
O2
Oxygen
31.98983
CH2O2
Formic acid
46.005478
ReactionCatalysis154613
ACTIVATION
3-hydroxyanthranilate 3,4-dioxygenase
Reaction164147
false
L-Kynurenine → Anthranilic Acid
LEFT_TO_RIGHT
SMILES
OC(=O)C1=CC=CN=C1C(O)=O
FORMATE
BioCyc
3712
ChemSpider
C10H12N2O3
L-Kynurenine
208.0848
3-HYDROXY-L-KYNURENINE
BioCyc
C01717
KEGG Compound
2-Amino-3-carboxymuconic acid semialdehyde
HMDB0000715
HMDB
CHEBI:15793
ChEBI
7782-44-7
CAS
606-14-4
CAS
HMDB0001377
HMDB
1.0
3845
PubChem-compound
SMILES
NC1=C(O)C=CC=C1C(O)=O
Reaction164272
false
Hydroxykynurenine → 3-Hydroxyanthranilic acid
LEFT_TO_RIGHT
9606
TAXONOMY
962
PubChem-compound
C00078
KEGG Compound
1.0
C03227
KEGG Compound
C00632
KEGG Compound
L-KYNURENINE
BioCyc
SMILES
O=O
CHEBI:30751
ChEBI
HMDB0000732
HMDB
P46952
UniProt
ReactionCatalysis1361
ACTIVATION
HMDB0002111
HMDB
2922-83-0
CAS
Q63HM1
UniProt
SMILES
OC=O
CHEBI:15377
ChEBI
CHEBI:15379
ChEBI
N'-Formylkynurenine
Hydroxykynurenine
SMP0121026
SMPDB
5886
PubChem-compound
HMDB0011631
HMDB
SMILES
N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O
CHEBI:16675
ChEBI
11318
ChemSpider
Kynurenine formamidase
C10H7NO3
Kynurenic acid
189.04259
64-18-6
CAS
N-FORMYLKYNURENINE
BioCyc
3-hydroxyanthranilate 3,4-dioxygenase
1.0
O15229
UniProt
22833512
PubChem-compound
H2O
Water
18.010565
1.0
L-Tryptophan
CHEBI:1547
ChEBI
141580
ChemSpider
977
PubChem-compound
Tryptophan 2,3-dioxygenase
1.0
1066
PubChem-compound
Formic acid
C10H12N2O4
Hydroxykynurenine
224.07971