454-29-5
CAS
1.0
365-07-1
CAS
937
ChemSpider
964-26-1
CAS
SMP0122040
SMPDB
CHEBI:16134
ChEBI
Bifunctional protein FolD
1.0
58-05-9
CAS
10-FORMYL-THF
BioCyc
C03838
KEGG Compound
Reaction179458
false
10-Formyltetrahydrofolate → N5-Formyl-THF
LEFT_TO_RIGHT
CHEBI:20506
ChEBI
7444-29-3
CAS
CHEBI:17115
ChEBI
C19H21N7O6
Dihydrofolic acid
443.15533
CHEBI:17119
ChEBI
C10H15N2O8P
5-Thymidylic acid
322.0566
C00440
KEGG Compound
CHEBI:17230
ChEBI
S-Aminomethyldihydrolipoylprotein;
C00445
KEGG Compound
6137
PubChem-compound
5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
BioCyc
5-METHYL-THF
BioCyc
18714427
ChemSpider
1.0
Bifunctional purine biosynthesis protein PurH
2.1.2.1
false
2.1.2.1
L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water
REVERSIBLE
Tetrahydrofolic acid
2.0
SMILES
[H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N=CO)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O
Dihydrofolic acid
SubPathwayOutput
CHEBI:16474
ChEBI
1.0
SMILES
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O
439175
PubChem-compound
Folic acid
A6V726
UniProt
10-Formyltetrahydrofolate
5736
ChemSpider
A6UX80
UniProt
METHYLENE-THF
BioCyc
Formate-dependent phosphoribosylglycinamide formyltransferase
1.0
1010
ChemSpider
C00101
KEGG Compound
6037
PubChem-compound
10074-18-7
CAS
B7UYK0
UniProt
1.0
C15H23N3O16P2
UDP-4-Deoxy-4-formamido-β-L-arabinose
563.05536
1.0
10-Formyltetrahydrofolate
Cytosol
C00234
KEGG Compound
5-FORMYL-THF
BioCyc
122347
PubChem-compound
Unknown
C00006
KEGG Compound
CHEBI:18009
ChEBI
Hydrogen Ion
C00001
KEGG Compound
Bifunctional polymyxin resistance protein ArnA
C00364
KEGG Compound
C00005
KEGG Compound
135-16-0
CAS
NADPH
388320
ChemSpider
C00365
KEGG Compound
Folate Biosynthesis
SubPathway
1.0
C00014
KEGG Compound
NAD(P)
BioCyc
CHEBI:18349
ChEBI
H
Hydrogen Ion
1.007825
SMILES
[H][C@]1(COP(O)(=O)OP(O)(=O)O[C@@]2([H])OC[C@]([H])(N)[C@]([H])(O)[C@@]2([H])O)O[C@@]([H])(N2C=CC(O)=NC2=O)[C@]([H])(O)[C@]1([H])O
58574
ChemSpider
C00143
KEGG Compound
MET
BioCyc
5,10-Methenyltetrahydrofolic acid
CHEBI:17013
ChEBI
3432-99-3
CAS
1.0
NADP
SMP0000925
SMPDB
C5H11NO2S
L-Methionine
149.05106
1.0
C03541
KEGG Compound
C00037
KEGG Compound
Formic acid
Water
HMDB0001227
HMDB
FAICAR
L-Methionyl-tRNA(Met)
98792
PubChem-compound
N-formylmethionyl-tRNA(fMet)
5-Thymidylic acid
Bifunctional purine biosynthesis protein PurH
644350
PubChem-compound
dihydrolipoylprotein
C04640
KEGG Compound
Glycineamideribotide
HMDB0001354
HMDB
DIHYDROFOLATE
BioCyc
1.0
HMDB0000142
HMDB
1.0
2.1.1.13
false
2.1.1.13
5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
LEFT_TO_RIGHT
2.1.2.9
false
2.1.2.9
N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid ? 10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met)
Reaction185647
false
FAICAR + Tetrahydrofolic acid → 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + 10-Formyltetrahydrofolate
LEFT_TO_RIGHT
2.1.2.-
false
2.1.2.-
5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Glycineamideribotide
LEFT_TO_RIGHT
3.5.1.10
false
3.5.1.10
Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Water
LEFT_TO_RIGHT
A6V1P0
UniProt
7732-18-5
CAS
C00058
KEGG Compound
Q02FG6
UniProt
AMMONIA
BioCyc
SMILES
N
Reaction185644
false
10-Formyltetrahydrofolate + 4-Amino-4-deoxy-L-arabinose → Tetrahydrofolate + UDP-4-Deoxy-4-formamido-β-L-arabinose
LEFT_TO_RIGHT
1.5.1.5
false
1.5.1.5
5,10-Methenyltetrahydrofolic acid + NADPH → 5,10-Methylene-THF + NADP
LEFT_TO_RIGHT
63-68-3
CAS
2.1.2.-
false
2.1.2.-
5'-phosphoribosyl-a-N-formylglycineamidine + Tetrahydrofolic acid → 5,10-Methenyltetrahydrofolic acid + Glycineamideribotide + Water
LEFT_TO_RIGHT
FORMATE
BioCyc
5,10-Methylene-THF
5907
ChemSpider
C20H23N7O7
10-Formyltetrahydrofolate
473.1659
56-40-6
CAS
SMILES
O[C@H]1[C@@H](O)[C@H](NC(=O)CNC=O)O[C@@H]1COP(O)(O)=O
C00065
KEGG Compound
5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
BioCyc
2800-34-2
CAS
4033-27-6
CAS
C19H23N7O6
Tetrahydrofolate
445.171
ReactionCatalysis175486
ACTIVATION
1.0
Tetrahydrofolate
ReactionCatalysis175487
ACTIVATION
CHEBI:18381
ChEBI
C00073
KEGG Compound
ReactionCatalysis175488
ACTIVATION
ReactionCatalysis175489
ACTIVATION
ReactionCatalysis175484
ACTIVATION
ReactionCatalysis175485
ACTIVATION
962
PubChem-compound
1.0
C8H16N3O8P
5'-phosphoribosyl-a-N-formylglycineamidine
313.0675
Tetrahydrofolic acid
C00080
KEGG Compound
730
ChemSpider
1.0
ReactionCatalysis175497
ACTIVATION
ReactionCatalysis175498
ACTIVATION
ReactionCatalysis175499
ACTIVATION
ReactionCatalysis175493
ACTIVATION
ReactionCatalysis175494
ACTIVATION
ReactionCatalysis175495
ACTIVATION
HMDB0000051
HMDB
Pseudomonas aeruginosa
1.0
ReactionCatalysis175496
ACTIVATION
HMDB0002111
HMDB
ReactionCatalysis175490
ACTIVATION
ReactionCatalysis175491
ACTIVATION
SMILES
OC=O
C4H9NO2S
Homocysteine
135.0354
ReactionCatalysis175492
ACTIVATION
TMP
BioCyc
5,10-Methenyltetrahydrofolic acid
5,10-methenyl-thf
BioCyc
Reaction185657
false
10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water
REVERSIBLE
2.1.2.10
false
2.1.2.10
5,10-Methenyltetrahydrofolic acid + Water → N5-Formyl-THF
LEFT_TO_RIGHT
C03479
KEGG Compound
1.0
HOMO-CYS
BioCyc
CHEBI:209153
ChEBI
SMILES
OC(=O)CCC(NC(=O)C1=CC=C(NCC2CNC3=C(N2C=O)C(O)=NC(=N)N3)C=C1)C(O)=O
FOLATE
BioCyc
SMILES
CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2
2.1.2.10
false
2.1.2.10
S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein
REVERSIBLE
1.5.1.3
false
1.5.1.3
Dihydrofolic acid + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
LEFT_TO_RIGHT
1.5.1.3
false
1.5.1.3
Dihydrofolic acid + NADP → Folic acid + Hydrogen Ion + NADPH
LEFT_TO_RIGHT
1.5.1.3
false
1.5.1.3
Folic acid + 2 Hydrogen Ion + 2 NADPH → 2 NADP + Tetrahydrofolic acid
LEFT_TO_RIGHT
2.1.1.45
false
2.1.1.45
5-Thymidylic acid + Dihydrofolic acid → 5,10-Methylene-THF + dUMP
LEFT_TO_RIGHT
C3H7NO3
L-Serine
105.042595
1.5.1.20
false
1.5.1.20
5,10-Methylene-THF + Hydrogen Ion + NADPH → 5-Methyltetrahydrofolic acid + NADP
LEFT_TO_RIGHT
HMDB0000187
HMDB
HMDB0001396
HMDB
SMILES
[H]C(=O)NC1=CN(N=C1C(N)=O)C1OC(COP(O)(O)=O)C(O)C1O
UDP-L-Ara4N formyltransferase / UDP-GlcA C-4"-decarboxylase
1.0
160913
PubChem-compound
64-18-6
CAS
SMILES
NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
757
ChemSpider
N-formylmethionyl-tRNA(fMet)
A6UYE6
UniProt
SMILES
[H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O
22833512
PubChem-compound
Glycine
SMILES
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1
1.0
H2O
Water
18.010565
SMILES
NCC(O)=O
5'-Phosphoribosyl-N-formylglycinamide
287
TAXONOMY
1.0
5815
ChemSpider
HMDB0059597
HMDB
559356
ChemSpider
5'-phosphoribosyl-a-N-formylglycineamidine
PW000908
PathWhiz
SMILES
[H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O
134-35-0
CAS
HMDB0001056
HMDB
HMDB0002022
HMDB
141370
ChemSpider
17215925
ChemSpider
C10H15N4O9P
FAICAR
366.05768
C9H15N4O8P
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
338.06274
1.0
1.0
1.0
C05330
KEGG Compound
Formate-dependent phosphoribosylglycinamide formyltransferase
ReactionCatalysis173310
ACTIVATION
Dihydrofolic acid
2.0
SMILES
O
H3N
Ammonia
17.026548
1.0
C8H15N2O9P
5'-Phosphoribosyl-N-formylglycinamide
314.0515
1.0
1.0
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1
5-Methyltetrahydrofolic acid
49791978
PubChem-compound
53-59-8
CAS
1038
PubChem-compound
C04376
KEGG Compound
SMILES
CSCC[C@H](N)C(O)=O
143
PubChem-compound
GO:0005829
GENE ONTOLOGY
278
ChemSpider
C19H23N7O6
Tetrahydrofolic acid
445.171
DUMP
BioCyc
Ammonia
Thymidylate synthase
HMDB0001409
HMDB
NADPH
1.0
SER
BioCyc
PW123348
PathWhiz
149
ChemSpider
HMDB0001533
HMDB
Glycineamideribotide
C7H15N2O8P
Glycineamideribotide
286.0566
NADP
C21H30N7O17P3
NADPH
745.0911
140
ChemSpider
C21H29N7O17P3
NADP
744.08325
THF
BioCyc
CHEBI:15641
ChEBI
NADPH
BioCyc
GLY
BioCyc
L-Methionyl-tRNA(Met)
217
ChemSpider
1.0
SMILES
NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1
HMDB0000696
HMDB
C20H21N7O6
5,10-Methenyltetrahydrofolic acid
455.15533
1.0
HMDB0000217
HMDB
CHEBI:15637
ChEBI
1.0
C2H5NO2
Glycine
75.03203
C19H19N7O6
Folic acid
441.13968
dUMP
N5-Formyl-THF
Methionyl-tRNA formyltransferase
Bifunctional protein FolD
9319
ChemSpider
HMDB0001308
HMDB
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
5,10-Methylene-THF
5257127
PubChem-compound
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
C20H23N7O6
5,10-Methylene-THF
457.171
SMILES
NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
7664-41-7
CAS
53-57-6
CAS
1.0
SMILES
OC=NCC(=N)NC1OC(COP(O)(O)=O)C(O)C1O
5951
PubChem-compound
222
PubChem-compound
Homocysteine
5,10-Methenyltetrahydrofolic acid
SMILES
NC(CCS)C(O)=O
1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
HMDB0001562
HMDB
5,10-Methenyltetrahydrofolic acid
Bifunctional protein FolD
CHEBI:15633
ChEBI
CHEBI:15636
ChEBI
1.0
HMDB0000123
HMDB
SMILES
N[C@@H](CO)C(O)=O
HMDB0002305
HMDB
HMDB0000121
HMDB
Bifunctional polymyxin resistance protein ArnA
CHEBI:17622
ChEBI
2.0
C9H13N2O8P
dUMP
308.04095
1.0
1.0
C14H23N3O15P2
4-Amino-4-deoxy-L-arabinose
535.0604
5675
ChemSpider
65063
PubChem-compound
1.0
dihydrolipoylprotein
1.0
18971002
PubChem-compound
Formate-dependent phosphoribosylglycinamide formyltransferase
CHEBI:16635
ChEBI
One Carbon Pool by Folate
CH2O2
Formic acid
46.005478
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O
Water
UDP-4-Deoxy-4-formamido-β-L-arabinose
C00504
KEGG Compound
9700
PubChem-compound
CHEBI:16643
ChEBI
Thymidylate synthase
349-34-8
CAS
SMILES
NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1
S-Aminomethyldihydrolipoylprotein;
N5-Formyl-THF
C20H23N7O7
N5-Formyl-THF
473.1659
C20H25N7O6
5-Methyltetrahydrofolic acid
459.18665
CHEBI:15428
ChEBI
115687
ChemSpider
1.0
130805
PubChem-compound
L-Methionine
439234
PubChem-compound
HMDB0000972
HMDB
CHEBI:30751
ChEBI
SMILES
NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1
Methionyl-tRNA formyltransferase
CHEBI:27470
ChEBI
L-Serine
1.0
CHEBI:15377
ChEBI
CHEBI:15378
ChEBI
SMILES
[H+]
CHEBI:18406
ChEBI
56-45-1
CAS
5886
PubChem-compound
SubPathwayInteraction112130
SubPathwayReaction
SubPathway112130Reaction
154
PubChem-compound
1.0
1.0
HMDB0000742
HMDB
C00415
KEGG Compound
89228
ChemSpider
1.0
388371
ChemSpider
17756769
PubChem-compound
4-Amino-4-deoxy-L-arabinose
Unknown
6.0
109092
ChemSpider
HMDB0001846
HMDB
13781857
PubChem-compound
59-30-3
CAS
1.0