PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128302 View Pathway	drug action Brexpiprazole Dopamine Agonist Action Pathway Homo sapiens Although the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and antagonist activity at 5-HT2A receptors. Brexpiprazole is predominantly, a 5-HT1A, D2, and D3 partial agonist and a 5-HT2A, 5-HT2B, 5-HT7, alpha1A, alpha1B, alpha1D, and alpha2C antagonist with a chemical formula of 7-{4-[4-(1-Benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one. Brexpiprazole is indicated as adjunctive therapy to antidepressants for the treatment of major depressive disorder in adults. It is also indicated for the treatment of schizophrenia in patients 13 years of age and older. Brexpiprazole is also indicated for the treatment of agitation associated with dementia due to Alzheimer’s disease. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 16, 2023 at 15:41 Last Updated: August 16, 2023 at 15:41
PW145997 View Pathway	drug action Brexpiprazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:09 Last Updated: October 07, 2023 at 17:09
PW176324 View Pathway	metabolic Brexpiprazole Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:05 Last Updated: December 07, 2023 at 15:05
PW128303 View Pathway	drug action Brexpiprazole Serotonin Action Action Pathway Homo sapiens Although the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and antagonist activity at 5-HT2A receptors. Brexpiprazole is predominantly, a 5-HT1A, D2, and D3 partial agonist and a 5-HT2A, 5-HT2B, 5-HT7, alpha1A, alpha1B, alpha1D, and alpha2C antagonist with a chemical formula of 7-{4-[4-(1-Benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one. Brexpiprazole is indicated as adjunctive therapy to antidepressants for the treatment of major depressive disorder in adults. It is also indicated for the treatment of schizophrenia in patients 13 years of age and older. Brexpiprazole is also indicated for the treatment of agitation associated with dementia due to Alzheimer’s disease. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 16, 2023 at 15:41 Last Updated: August 16, 2023 at 15:41
PW146508 View Pathway	drug action Brigatinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:22 Last Updated: October 07, 2023 at 18:22
PW132401 View Pathway	metabolic Brilliant blue G Drug Metabolism Homo sapiens Brilliant blue G is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Brilliant blue G passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:29 Last Updated: September 21, 2023 at 21:29
PW146931 View Pathway	drug action Brilliant blue G Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:23 Last Updated: October 07, 2023 at 19:23
PW146338 View Pathway	drug action Brilliant green cation Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:58 Last Updated: October 07, 2023 at 17:58
PW144606 View Pathway	drug action Brimonidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:00 Last Updated: October 07, 2023 at 14:00
PW127462 View Pathway	drug action Brincidofovir Action Pathway Homo sapiens Brincidofovir is an oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. It is a lipid conjugate pro-drug of the acyclic nucleotide analogue cidofovir. . Brincidofovir is a pro-drug comprising cidofovir conjugated to a lipid molecule - the lipid component mimics an endogenous lipid, lysophosphatidylcholine, which allows the molecule to hijack endogenous lipid uptake pathways to enter infected cells. Following uptake, the lipid molecule is cleaved to generate cidofovir, which is then phosphorylated to generate the active antiviral compound, cidofovir disphosphate. Cidofovir acts through the selective inhibition of viral DNA polymerase. After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to the active metabolite cidofovir diphosphate. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis. Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Less viral proteins produced, fewer viruses can form. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: March 01, 2023 at 10:33 Last Updated: March 01, 2023 at 10:33