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Showing 1 - 50 of 2719 proteins
ID Protein Pathways


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succinate:quinone oxidoreductase, FAD binding protein

Gene Name: SdhA


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5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Gene Name: mtn

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n-butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza-adenosylhomocysteine as substrates.


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5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase

Gene Name: yigB

Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway (PubMed:24123841). Is also able to dephosphorylate flavin mononucleotide (FMN) and other phosphoric acid esters (PubMed:16990279) (PubMed:24123841). YigB is important for the formation of dormant persister cells (PubMed:18519731).


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dTDP-glucose pyrophosphorylase

Gene Name: rmlA1

Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.


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Galactoside O-acetyltransferase

Gene Name: lacA


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glycerol 3-phosphatase 2

Gene Name: GPP2

Glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation.


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L-cystine ABC transporter - periplasmic binding protein

Gene Name: fliY

FliY is the periplasmic binding protein of an L-cystine/L-cysteine ABC transport system in E. coli K-12. (EcoCyc)


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putative protein secretion protein for export L

Gene Name: gspL

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.


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putative protein secretion protein for export M

Gene Name: gspM

Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.


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(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Gene Name: fabZ

Involved in hydro-lyase activity. Involved in saturated fatty acids biosynthesis.


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1,4-alpha-glucan-branching enzyme

Gene Name: GBE1

Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells.


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1,4-alpha-glucan-branching enzyme

Gene Name: glgB

Involved in 1,4-alpha-glucan branching enzyme activity. Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Has a preference for transferring chains of 5 to 16 glucose units.


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1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene Name: menA

Involved in transferase activity. Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA as CO(2), the attachment of the isoprenoid side chain, and a quinol-to-quinone oxidation, which is thought to be spontaneous.


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1,4-dihydroxy-2-naphthoyl-CoA thioesterase

Gene Name: menI

Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). Also shows significant activity toward a wide range of acyl-CoA thioesters, and minimal activity toward benzoyl-holoEntB.


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1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD

Gene Name: ampD

Involved in N-acetylmuramoyl-L-alanine amidase activity. Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety.


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1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene Name: hisA

Involved in catalytic activity. 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5- ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5- phosphoribosyl)imidazole-4-carboxamide.


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1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene Name: HIS6

Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR.


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1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene Name: plsC

Involved in transferase activity, transferring acyl groups. Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor.


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1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Gene Name: AGPAT1

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.


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1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene Name: dxr

Involved in 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity. Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).


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1-deoxy-D-xylulose-5-phosphate synthase

Gene Name: dxs

Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity. Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).


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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene Name: PLCB1

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.


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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Gene Name: PLCD3

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.


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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Gene Name: PLCG1

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.


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1-phosphatidylinositol-3-phosphate 5-kinase

Gene Name: PIKFYVE

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes


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Gene Name: fruK


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14 kDa phosphohistidine phosphatase

Gene Name: PHPT1

Exhibits phosphohistidine phosphatase activity.


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14-3-3 protein epsilon

Gene Name: YWHAE

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.


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2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Gene Name: cpdB

Involved in hydrolase activity. This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate.


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2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene Name: dapD

Involved in 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity. Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate.


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2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene Name: gpmA


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2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene Name: gpmM


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2,3-dehydroadipyl-CoA hydratase

Gene Name: paaF

Catalyzes the reversible conversion of enzymatically produced 2,3-dehydroadipyl-CoA into 3-hydroxyadipyl-CoA.


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2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

Gene Name: entA

Involved in oxidoreductase activity. 2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH.


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2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase

Gene Name: mhpB

Involved in iron ion binding. Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively.


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2,3-diketo-L-gulonate reductase

Gene Name: dlgD

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.


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2,3-dioxomethiopentane-1-phosphate enolase/phosphatase

Gene Name: UTR4

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


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2,4-dienoyl-CoA reductase [NADPH]

Gene Name: fadH

Involved in catalytic activity. Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA.


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2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

Gene Name: RIB7

Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.


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2,5-diketo-D-gluconic acid reductase A

Gene Name: dkgA

Involved in oxidoreductase activity. Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


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2,5-diketo-D-gluconic acid reductase B

Gene Name: dkgB

Involved in oxidoreductase activity. Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


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2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Gene Name: citG

Involved in ATP binding. Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA.


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2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Gene Name: ACMSD

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.


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2-amino-3-ketobutyrate coenzyme A ligase

Gene Name: kbl

Involved in glycine C-acetyltransferase activity. Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.


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2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Gene Name: GCAT


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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene Name: folK

Involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity. ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate.


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2-aminoethanethiol dioxygenase

Gene Name: ADO


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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Gene Name: ispF

Involved in 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. Converts 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) and CMP. Also converts 4-diphosphocytidyl-2-C-methyl-D- erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.


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2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Gene Name: ispD

Involved in catalytic activity. Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP).


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2-dehydro-3-deoxy-6-phosphogalactonate aldolase

Gene Name: dgoA

Involved in catalytic activity. 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
Showing 1 - 50 of 2719 proteins