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Showing 21 - 40 of 1542 proteins

Protein ID

Protein

Pathways

P62191

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26S protease regulatory subunit 4

Gene Name: PSMC1

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

P17980

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26S protease regulatory subunit 6A

Gene Name: PSMC3

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.

P43686

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26S protease regulatory subunit 6B

Gene Name: PSMC4

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

P35998

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26S protease regulatory subunit 7

Gene Name: PSMC2

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.

P62195

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26S protease regulatory subunit 8

Gene Name: PSMC5

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Q9UNM6

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26S proteasome non-ATPase regulatory subunit 13

Gene Name: PSMD13

Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

P55036

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26S proteasome non-ATPase regulatory subunit 4

Gene Name: PSMD4

Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.

Q9H2F3

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HMDBP04980

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3 beta-hydroxysteroid dehydrogenase type 7

Gene Name: HSD3B7

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.

P14060

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HMDBP04403

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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Gene Name: HSD3B1

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

P26439

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HMDBP04404

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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Gene Name: HSD3B2

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

O95861

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HMDBP00342

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3'(2'),5'-bisphosphate nucleotidase 1

Gene Name: BPNT1

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

Q15125

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HMDBP00949

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3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Gene Name: EBP

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

P04035

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HMDBP00910

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3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene Name: HMGCR

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Q99714

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HMDBP00379

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3-hydroxyacyl-CoA dehydrogenase type-2

Gene Name: HSD17B10

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

P46952

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HMDBP01128

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3-hydroxyanthranilate 3,4-dioxygenase

Gene Name: HAAO

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

P31937

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HMDBP00395

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3-hydroxyisobutyrate dehydrogenase, mitochondrial

Gene Name: HIBADH

Q6NVY1

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HMDBP04709

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3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene Name: HIBCH

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

P56937

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HMDBP00848

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3-keto-steroid reductase

Gene Name: HSD17B7

Responsible for the reduction of the keto group on the C-3 of sterols.

P42765

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HMDBP00031

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3-ketoacyl-CoA thiolase, mitochondrial

Gene Name: ACAA2

Abolishes BNIP3-mediated apoptosis and mitochondrial damage.

Q06136

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HMDBP03056

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3-ketodihydrosphingosine reductase

Gene Name: KDSR

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Showing 21 - 40 of 1542 proteins