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Showing 61 - 80 of 1542 proteins

Protein ID

Protein

Pathways

P60866

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40S ribosomal protein S20

Gene Name: RPS20

P63220

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40S ribosomal protein S21

Gene Name: RPS21

P62266

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40S ribosomal protein S23

Gene Name: RPS23

P62847

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40S ribosomal protein S24

Gene Name: RPS24

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

P62851

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40S ribosomal protein S25

Gene Name: RPS25

P62854

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40S ribosomal protein S26

Gene Name: RPS26

P42677

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HMDBP08171

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40S ribosomal protein S27

Gene Name: RPS27

P62857

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40S ribosomal protein S28

Gene Name: RPS28

P62273

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40S ribosomal protein S29

Gene Name: RPS29

P23396

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40S ribosomal protein S3

Gene Name: RPS3

Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

P62861

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40S ribosomal protein S30

Gene Name: FAU

P61247

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40S ribosomal protein S3a

Gene Name: RPS3A

May play a role during erythropoiesis through regulation of transcription factor DDIT3.

P62701

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40S ribosomal protein S4, X isoform

Gene Name: RPS4X

P46782

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40S ribosomal protein S5

Gene Name: RPS5

P62753

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40S ribosomal protein S6

Gene Name: RPS6

May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

P62081

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40S ribosomal protein S7

Gene Name: RPS7

Required for rRNA maturation.

P62241

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40S ribosomal protein S8

Gene Name: RPS8

P46781

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40S ribosomal protein S9

Gene Name: RPS9

P08865

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40S ribosomal protein SA

Gene Name: RPSA

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.

P08195

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HMDBP03090

View in HMDB

4F2 cell-surface antigen heavy chain

Gene Name: SLC3A2

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier
Showing 61 - 80 of 1542 proteins