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Showing 81 - 100 of 1588 proteins

Protein ID

Protein

Pathways

P08195

View in UniProt

HMDBP03090

View in HMDB

4F2 cell-surface antigen heavy chain

Gene Name: SLC3A2

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier

Q8TCD5

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HMDBP00006

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5'(3')-deoxyribonucleotidase, cytosolic type

Gene Name: NT5C

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

P21589

View in UniProt

HMDBP00001

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5'-nucleotidase

Gene Name: NT5E

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

P17643

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HMDBP02139

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5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene Name: TYRP1

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized

P13196

View in UniProt

HMDBP00022

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5-aminolevulinate synthase, nonspecific, mitochondrial

Gene Name: ALAS1

P49914

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HMDBP01408

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5-formyltetrahydrofolate cyclo-ligase

Gene Name: MTHFS

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.

P08908

View in UniProt

HMDBP02566

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5-hydroxytryptamine receptor 1A

Gene Name: HTR1A

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

P28335

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HMDBP02700

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5-hydroxytryptamine receptor 2C

Gene Name: HTR2C

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Q13639

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HMDBP02219

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5-hydroxytryptamine receptor 4

Gene Name: HTR4

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

P50406

View in UniProt

HMDBP02713

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5-hydroxytryptamine receptor 6

Gene Name: HTR6

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs

P34969

View in UniProt

HMDBP02268

View in HMDB

5-hydroxytryptamine receptor 7

Gene Name: HTR7

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

O14841

View in UniProt

HMDBP00855

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5-oxoprolinase

Gene Name: OPLAH

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

P16118

View in UniProt

HMDBP00799

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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Gene Name: PFKFB1

Synthesis and degradation of fructose 2,6-bisphosphate.

P17858

View in UniProt

HMDBP00758

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6-phosphofructokinase, liver type

Gene Name: PFKL

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.

P08237

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HMDBP00762

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6-phosphofructokinase, muscle type

Gene Name: PFKM

Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.

P52209

View in UniProt

HMDBP01039

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6-phosphogluconate dehydrogenase, decarboxylating

Gene Name: PGD

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).

O95336

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HMDBP00327

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6-phosphogluconolactonase

Gene Name: PGLS

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Q03393

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HMDBP00435

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6-pyruvoyl tetrahydrobiopterin synthase

Gene Name: PTS

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

P05388

View in UniProt

60S acidic ribosomal protein P0

Gene Name: RPLP0

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

P05386

View in UniProt

60S acidic ribosomal protein P1

Gene Name: RPLP1

Plays an important role in the elongation step of protein synthesis.
Showing 81 - 100 of 1588 proteins