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Proteins

Showing 51 - 100 of 2727 proteins
ID Protein Pathways

P37769

View in UniProt

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

Gene Name: kduD

Involved in 2-deoxy-D-gluconate 3-dehydrogenase activity. Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH.

P31459

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2-dehydro-3-deoxygalactonokinase

Gene Name: dgoK

Carbohydrate transport and metabolism. ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate.

P37647

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2-dehydro-3-deoxygluconokinase

Gene Name: kdgK

Involved in phosphotransferase activity, alcohol group as acceptor. ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 6- phospho-2-dehydro-3-deoxy-D-gluconate.

P0A715

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2-dehydro-3-deoxyphosphooctonate aldolase

Gene Name: kdsA

Involved in catalytic activity. Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.

P0A9J4

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2-dehydropantoate 2-reductase

Gene Name: panE

Involved in oxidation-reduction process. Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

P38071

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2-enoyl thioester reductase

Gene Name: ETR1

Required for respiration and the maintenance of the mitochondrial compartment. Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.

P0ABQ2

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2-hydroxy-3-oxopropionate reductase

Gene Name: garR

Involved in 3-hydroxyisobutyrate dehydrogenase activity. (R)-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H.

P77161

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2-hydroxy-3-oxopropionate reductase_

Gene Name: glxR

Involved in 3-hydroxyisobutyrate dehydrogenase activity. (R)-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H.

P77044

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2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase

Gene Name: mhpC

Involved in catalytic activity. Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid.

Q9UJ83

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HMDBP08729

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2-hydroxyacyl-CoA lyase 1

Gene Name: HACL1

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.

Q16880

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HMDBP01101

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2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Gene Name: UGT8

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.

P06208

View in UniProt

2-isopropylmalate synthase

Gene Name: LEU4

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

P09151

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2-isopropylmalate synthase

Gene Name: leuA

Involved in 2-isopropylmalate synthase activity. Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

Q12166

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2-isopropylmalate synthase LEU9

Gene Name: LEU9

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis.

P0A712

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2-keto-3-deoxygluconate permease

Gene Name: kdgT

Involved in 2-keto-3-deoxygluconate:hydrogen symporter activity. The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system.

P77608

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2-keto-4-pentenoate hydratase

Gene Name: mhpD

Involved in catalytic activity. Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.

Q5HYK3

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HMDBP07419

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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene Name: COQ5

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity).

P77243

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2-methylcitrate dehydratase

Gene Name: prpD

Involved in 2-methylcitrate dehydratase activity. Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate. Also seems to be responsible for the residual aconitase activity of the acnAB-null strain.

P31660

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2-methylcitrate synthase

Gene Name: prpC

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer. Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity.

P13669

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2-O-α-mannosyl-D-glycerate PTS permease

Gene Name: mngR

Represses mngA and mngB. Regulates its own expression.

P75728

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2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase

Gene Name: ubiF

Involved in oxidoreductase activity. Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol.

P25534

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2-octaprenyl-6-methoxyphenol hydroxylase

Gene Name: ubiH

Involved in oxidoreductase activity. Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone.

A0A0A1AE59

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2-octaprenyl-6-methoxyphenyl hydroxylase

Gene Name: ECONIH1_16735

P25535

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2-octaprenylphenol hydroxylase

Gene Name: ubiI

FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis.

P0AFG3

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2-oxoglutarate dehydrogenase E1 component

Gene Name: sucA

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

P20967

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2-oxoglutarate dehydrogenase, mitochondrial

Gene Name: KGD1

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Q02218

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HMDBP00439

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2-oxoglutarate dehydrogenase, mitochondrial

Gene Name: OGDH

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Q68EW0

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2-oxoglutarate dehydrogenase-like, mitochondrial

Gene Name: ogdhl

P12694

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HMDBP00300

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2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Gene Name: BCKDHA

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

P21953

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HMDBP00299

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2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

Gene Name: BCKDHB

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

P17109

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2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene Name: menD

Involved in thiamine pyrophosphate binding. Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC).

P37355

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2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene Name: menH

Involved in 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity. Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.

P37353

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2-succinylbenzoate--CoA ligase

Gene Name: menE

Involved in catalytic activity. Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA).

Q9NYL5

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HMDBP05845

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24-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP39A1

Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.

O75881

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HMDBP01629

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25-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP7B1

Q9H2F3

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HMDBP04980

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3 beta-hydroxysteroid dehydrogenase type 7

Gene Name: HSD3B7

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.

P14060

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HMDBP04403

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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Gene Name: HSD3B1

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

P26439

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HMDBP04404

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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Gene Name: HSD3B2

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

O95861

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HMDBP00342

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3'(2'),5'-bisphosphate nucleotidase 1

Gene Name: BPNT1

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

P22255

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3'(2'),5'-bisphosphate nucleotidase cysQ

Gene Name: cysQ

Involved in magnesium ion binding. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2).

Q99258

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3,4-dihydroxy 2-butanone 4-phosphate synthase

Gene Name: RIB3

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

P0A7J0

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3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene Name: ribB

Involved in 3,4-dihydroxy-2-butanone-4-phosphate synthase activity. Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

P77397

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3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase

Gene Name: mhpA

Involved in 3-(3-hydroxyphenyl)propionate hydroxylase activity. Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).

Q15125

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HMDBP00949

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3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Gene Name: EBP

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

P05194

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3-dehydroquinate dehydratase

Gene Name: aroD

Involved in 3-dehydroquinate dehydratase activity. 3-dehydroquinate = 3-dehydroshikimate + H(2)O.

P07639

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3-dehydroquinate synthase

Gene Name: aroB

Involved in 3-dehydroquinate synthase activity. 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.

Q8VYV7

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3-dehydroquinate synthase

Gene Name: DHQS

3-dehydroquinate synthase is an enzyme in the chloroplast that catalyzes the second chemical reaction in the shikimate pathway whereby a phosphate is eliminated from 3-deoxy-D-arabino-heptulosonate 7-phosphate resulting in 3-dehydroquinate. It requires NAD+ and a divalent cation (e.g. cobalt) as cofactors (Wikipedia).

P17993

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3-demethylubiquinone-9 3-methyltransferase

Gene Name: ubiG

Involved in 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. S-adenosyl-L-methionine + 3- demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.

P0ABZ4

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3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Gene Name: kdsC

Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity. Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate.

P0AC75

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3-deoxy-D-manno-octulosonic-acid transferase

Gene Name: waaA

Involved in biosynthetic process. Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA. Degraded by FtsH; therefore FtsH regulates the addition of the sugar moiety of the LPS and thus the maturation of the LPS precursor.
Showing 51 - 100 of 2727 proteins