Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.

Proteins

Showing 101 - 150 of 3625 proteins
ID Protein Pathways

Q9FLH2

View in UniProt

2-oxoglutarate dehydrogenase, E1 component 2

Gene Name: At5g65750

P20967

View in UniProt

2-oxoglutarate dehydrogenase, mitochondrial

Gene Name: KGD1

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Q02218

View in UniProt

HMDBP00439

View in HMDB

2-oxoglutarate dehydrogenase, mitochondrial

Gene Name: OGDH

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

Q68EW0

View in UniProt

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene Name: ogdhl

Q84JL2

View in UniProt

2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial

Gene Name: At5g09300

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

P12694

View in UniProt

HMDBP00300

View in HMDB

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Gene Name: BCKDHA

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Q9LDY2

View in UniProt

2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial

Gene Name: DIN4

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required during sugar starvation and acts under the control of a sugar-sensing mechanism involving Ser/Thr kinases and phosphatases.

P21953

View in UniProt

HMDBP00299

View in HMDB

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

Gene Name: BCKDHB

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

P17109

View in UniProt

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene Name: menD

Involved in thiamine pyrophosphate binding. Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC).

P37355

View in UniProt

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene Name: menH

Involved in 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity. Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.

P37353

View in UniProt

2-succinylbenzoate--CoA ligase

Gene Name: menE

Involved in catalytic activity. Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA).

Q9NYL5

View in UniProt

HMDBP05845

View in HMDB

24-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP39A1

Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.

O75881

View in UniProt

HMDBP01629

View in HMDB

25-hydroxycholesterol 7-alpha-hydroxylase

Gene Name: CYP7B1

Q9H2F3

View in UniProt

HMDBP04980

View in HMDB

3 beta-hydroxysteroid dehydrogenase type 7

Gene Name: HSD3B7

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis.

P14060

View in UniProt

HMDBP04403

View in HMDB

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Gene Name: HSD3B1

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

P26439

View in UniProt

HMDBP04404

View in HMDB

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Gene Name: HSD3B2

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

O95861

View in UniProt

HMDBP00342

View in HMDB

3'(2'),5'-bisphosphate nucleotidase 1

Gene Name: BPNT1

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

P22255

View in UniProt

3'(2'),5'-bisphosphate nucleotidase cysQ

Gene Name: cysQ

Involved in magnesium ion binding. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2).

Q99258

View in UniProt

3,4-dihydroxy 2-butanone 4-phosphate synthase

Gene Name: RIB3

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

P0A7J0

View in UniProt

3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene Name: ribB

Involved in 3,4-dihydroxy-2-butanone-4-phosphate synthase activity. Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.

Q1H537

View in UniProt

3,8-divinyl protochlorophyllide a 8-vinyl-reductase

Gene Name: DVR

3,8-divinyl protochlorophyllide a 8-vinyl-reductase is an enzyme in the chloroplast that catalyzes a reaction in the chlorophyll a biosynthesis I pathway whereby 3,8-divinyl chlorophyllide a is converted into chlorophyllide a.

P77397

View in UniProt

3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase

Gene Name: mhpA

Involved in 3-(3-hydroxyphenyl)propionate hydroxylase activity. Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).

Q15125

View in UniProt

HMDBP00949

View in HMDB

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Gene Name: EBP

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

P05194

View in UniProt

3-dehydroquinate dehydratase

Gene Name: aroD

Involved in 3-dehydroquinate dehydratase activity. 3-dehydroquinate = 3-dehydroshikimate + H(2)O.

P07639

View in UniProt

3-dehydroquinate synthase

Gene Name: aroB

Involved in 3-dehydroquinate synthase activity. 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.

Q8VYV7

View in UniProt

3-dehydroquinate synthase

Gene Name: DHQS

3-dehydroquinate synthase is an enzyme in the chloroplast that catalyzes the second chemical reaction in the shikimate pathway whereby a phosphate is eliminated from 3-deoxy-D-arabino-heptulosonate 7-phosphate resulting in 3-dehydroquinate. It requires NAD+ and a divalent cation (e.g. cobalt) as cofactors (Wikipedia).

P17993

View in UniProt

3-demethylubiquinone-9 3-methyltransferase

Gene Name: ubiG

Involved in 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. S-adenosyl-L-methionine + 3- demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.

Q9AV97

View in UniProt

3-deoxy-8-phosphooctulonate synthase

Gene Name: KDSA1

3-deoxy-8-phosphooctulonate synthase is an enzyme in the cytosol that catalyzes a reaction in the CMP-3-deoxy-D-manno-octulosonate (CMP-Kdo) pathway whereby D-arabinofuranose 5-phosphate is converted into 3-deoxy-D-manno-octulosonate 8-phosphate (KDO-8P). The enzme is a homotetramer.

P0ABZ4

View in UniProt

3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Gene Name: kdsC

Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity. Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate.

P0AC75

View in UniProt

3-deoxy-D-manno-octulosonic-acid transferase

Gene Name: waaA

Involved in biosynthetic process. Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA. Degraded by FtsH; therefore FtsH regulates the addition of the sugar moiety of the LPS and thus the maturation of the LPS precursor.

Q9C920

View in UniProt

3-deoxy-manno-octulosonate cytidylyltransferase

Gene Name: KDSB

3-deoxy-manno-octulosonate cytidylyltransferase is an enzyme localized to the mitochondrial outer membrane that catalyzes a reaction in the CMP-3-deoxy-D-manno-octulosonate (CMP-Kdo) pathway whereby 3-deoxy-D-manno-2-octulosonate (Kdo) is converted into CMP-3-deoxy-D-manno-octulosonate (CMP-Kdo). It requires a magnesium ion as a cofactor.

P04951

View in UniProt

3-deoxy-manno-octulosonate cytidylyltransferase

Gene Name: kdsB

Involved in lipopolysaccharide biosynthetic process. Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.

Z0Z000

View in UniProt

3-deoxy-manno-octulosonate-8-phosphatase

Gene Name: ?

3-deoxy-manno-octulosonate-8-phosphatase is a predicted enzyme in the cytosol theorized to catalyze a reaction in the CMP-3-deoxy-D-manno-octulosonate (CMP-Kdo) pathway whereby 3-deoxy-D-manno-octulosonate 8-phosphate (KDO-8P) is converted into 3-deoxy-D-manno-2-octulosonate (Kdo).

P76143

View in UniProt

3-hydroxy-2,4-pentadione 5-phosphate thiolase

Gene Name: lsrF

Could be involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.

Z0Z000

View in UniProt

3-hydroxy-3-methylglutaryl-CoA transporter

Gene Name: ?

3-hydroxy-3-methylglutaryl-CoA transporter is a predicted transporter localized to the mitochondria inner membrane that is theorized to import 3-hydroxy-3-methylglutaryl-CoA into the mitochondrial matrix from the cytosol.

P04035

View in UniProt

HMDBP00910

View in HMDB

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene Name: HMGCR

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

P12683

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Gene Name: HMG1

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12683

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Gene Name: HMG1

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12683

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Gene Name: HMG1

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12683

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Gene Name: HMG1

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12684

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Gene Name: HMG2

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12684

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Gene Name: HMG2

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12684

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Gene Name: HMG2

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

P12684

View in UniProt

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Gene Name: HMG2

One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.

Z0Z000

View in UniProt

3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Gene Name: ?

3-hydroxyacyl-[acyl-carrier-protein] dehydratase is a predicted enzyme in the chloroplast theorized to catalyze a reaction in fatty acid elongation whereby a (3R)-3-hydroxyacyl-[acyl-carrier protein] is converted into a trans-2-enoyl-[acyl-carrier protein].

Q99714

View in UniProt

HMDBP00379

View in HMDB

3-hydroxyacyl-CoA dehydrogenase type-2

Gene Name: HSD17B10

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

P46952

View in UniProt

HMDBP01128

View in HMDB

3-hydroxyanthranilate 3,4-dioxygenase

Gene Name: HAAO

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

P47096

View in UniProt

3-hydroxyanthranilate 3,4-dioxygenase

Gene Name: BNA1

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

A0A1I9LST4

View in UniProt

3-hydroxybutyryl-CoA dehydrogenase

Gene Name: At3g15290

3-hydroxybutyryl-CoA dehydrogenase is a predicted enzyme in the cytosol that is theorized to catalyze a reaction in butanoate metabolism whereby 3-hydroxybutanoyl-CoA is reversibly converted into acetoacetyl-CoA.

P0A6Q3

View in UniProt

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene Name: fabA

Involved in catalytic activity. Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP.
Showing 101 - 150 of 3625 proteins