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Proteins

Showing 101 - 150 of 2719 proteins
ID Protein Pathways

P04951

View in UniProt

3-deoxy-manno-octulosonate cytidylyltransferase

Gene Name: kdsB

Involved in lipopolysaccharide biosynthetic process. Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.

P76143

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3-hydroxy-2,4-pentadione 5-phosphate thiolase

Gene Name: lsrF

Could be involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle.

P04035

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HMDBP00910

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3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene Name: HMGCR

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Q99714

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HMDBP00379

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3-hydroxyacyl-CoA dehydrogenase type-2

Gene Name: HSD17B10

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

P46952

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HMDBP01128

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3-hydroxyanthranilate 3,4-dioxygenase

Gene Name: HAAO

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

P47096

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3-hydroxyanthranilate 3,4-dioxygenase

Gene Name: BNA1

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

P0A6Q3

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3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene Name: fabA

Involved in catalytic activity. Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP.

P31937

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HMDBP00395

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3-hydroxyisobutyrate dehydrogenase, mitochondrial

Gene Name: HIBADH

P28817

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3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene Name: EHD3

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit.

Q6NVY1

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HMDBP04709

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3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene Name: HIBCH

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.

P07264

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3-isopropylmalate dehydratase

Gene Name: LEU1

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

P07264

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3-isopropylmalate dehydratase

Gene Name: LEU1

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

P0A6A6

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3-isopropylmalate dehydratase large subunit

Gene Name: leuC

Involved in 3-isopropylmalate dehydratase activity. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

P30126

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3-isopropylmalate dehydratase small subunit

Gene Name: leuD

Involved in 3-isopropylmalate dehydratase activity. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

P30125

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3-isopropylmalate dehydrogenase

Gene Name: leuB

Involved in magnesium ion binding. Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.

P37678

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3-keto-L-gulonate-6-phosphate decarboxylase sgbH

Gene Name: sgbH

Involved in catalytic activity. Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate.

P39304

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3-keto-L-gulonate-6-phosphate decarboxylase ulaD

Gene Name: ulaD

Involved in magnesium ion binding. Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization.

P56937

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HMDBP00848

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3-keto-steroid reductase

Gene Name: HSD17B7

Responsible for the reduction of the keto group on the C-3 of sterols.

P39540

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3-ketoacyl-CoA synthase ELO1

Gene Name: ELO1

Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids. Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA.

P21151

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3-ketoacyl-CoA thiolase

Gene Name: fadA

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids.

P42765

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HMDBP00031

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3-ketoacyl-CoA thiolase, mitochondrial

Gene Name: ACAA2

Abolishes BNIP3-mediated apoptosis and mitochondrial damage.

P27796

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3-ketoacyl-CoA thiolase, peroxisomal

Gene Name: POT1

P27796

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3-ketoacyl-CoA thiolase, peroxisomal

Gene Name: POT1

P27796

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3-ketoacyl-CoA thiolase, peroxisomal

Gene Name: POT1

P27796

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3-ketoacyl-CoA thiolase, peroxisomal

Gene Name: POT1

P27796

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3-ketoacyl-CoA thiolase, peroxisomal

Gene Name: POT1

P76503

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3-ketoacyl-CoA thiolase_

Gene Name: fadI

Involved in transferase activity. Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids.

Q06136

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HMDBP03056

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3-ketodihydrosphingosine reductase

Gene Name: KDSR

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).

P38342

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3-ketosphinganine reductase

Gene Name: TSC10

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).

P25325

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HMDBP00781

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3-mercaptopyruvate sulfurtransferase

Gene Name: MPST

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.

P31142

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3-mercaptopyruvate sulfurtransferase

Gene Name: sseA

Involved in thiosulfate sulfurtransferase activity. Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity.

P31057

View in UniProt

3-methyl-2-oxobutanoate hydroxymethyltransferase

Gene Name: panB

Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity. Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate.

P0AAB4

View in UniProt

3-octaprenyl-4-hydroxybenzoate carboxy-lyase

Gene Name: ubiD

Involved in carboxy-lyase activity. Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol.

P0AG03

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3-octaprenyl-4-hydroxybenzoate carboxy-lyase

Gene Name: ubiX

Coenzyme transport and metabolism. Specific function unknown.

P18405

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HMDBP00699

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3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene Name: SRD5A1

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

P51857

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HMDBP00550

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3-oxo-5-beta-steroid 4-dehydrogenase

Gene Name: AKR1D1

Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.

P0AEK2

View in UniProt

3-oxoacyl-[acyl-carrier-protein] reductase

Gene Name: fabG

Involved in 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity. (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

P35731

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3-oxoacyl-[acyl-carrier-protein] reductase

Gene Name: OAR1

Involved in biosynthesis of fatty acids in mitochondria.

P0A953

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3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene Name: fabB

Involved in catalytic activity. Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.

P0AAI5

View in UniProt

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene Name: fabF

Involved in transferase activity, transferring acyl groups other than amino-acyl groups. Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.

P0A6R0

View in UniProt

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene Name: fabH

Involved in 3-oxoacyl-[acyl-carrier-protein] synthase activity. Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.

B1IUH4

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3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene Name: fabH

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.

P0CI31

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3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase

Gene Name: hcaB

Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively (By similarity). Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively (By similarity)..

P0ABW0

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3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit

Gene Name: hcaC

Involved in oxidoreductase activity. Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin.

P77650

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3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component

Gene Name: hcaD

Involved in oxidoreductase activity. Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.

P0ABR5

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3-phenylpropionate/cinnamic acid dioxygenase subunit alpha

Gene Name: hcaE

Involved in iron ion binding. Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.

Q47140

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3-phenylpropionate/cinnamic acid dioxygenase subunit beta

Gene Name: hcaF

Involved in 3-phenylpropionate dioxygenase activity. Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.

O15530

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HMDBP01430

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3-phosphoinositide-dependent protein kinase 1

Gene Name: PDPK1

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development. Isoform 3 is catalytically inactive

P0A6D3

View in UniProt

3-phosphoshikimate 1-carboxyvinyltransferase

Gene Name: aroA

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups. Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.

P19925

View in UniProt

4'-phosphopantetheinyl transferase entD

Gene Name: entD

Involved in magnesium ion binding. Catalyzes the transfer of the 4'-phosphopantetheine moiety from coenzyme A to apo-domains of both entB (an ArCP domain) and entF (a PCP domain). Plays an essential role in the assembly of the enterobactin.
Showing 101 - 150 of 2719 proteins