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Proteins

Showing 201 - 250 of 2719 proteins
ID Protein Pathways

P52209

View in UniProt

HMDBP01039

View in HMDB

6-phosphogluconate dehydrogenase, decarboxylating

Gene Name: PGD

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).

O95336

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HMDBP00327

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6-phosphogluconolactonase

Gene Name: PGLS

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

P52697

View in UniProt

6-phosphogluconolactonase

Gene Name: pgl

Involved in 6-phosphogluconolactonase activity. Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Q03393

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HMDBP00435

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6-pyruvoyl tetrahydrobiopterin synthase

Gene Name: PTS

Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

P50277

View in UniProt

7,8-diamino-pelargonic acid aminotransferase

Gene Name: BIO3

Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.

Q9UNU6

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HMDBP06125

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7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Gene Name: CYP8B1

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.

P77756

View in UniProt

7-cyano-7-deazaguanine synthase

Gene Name: queC

Involved in argininosuccinate synthase activity. Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

P53744

View in UniProt

7-keto 8-aminopelargonic acid transporter

Gene Name: BIO5

Transport into the cell of 7-keto 8-aminopelargonic acid.

Q9NRR6

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HMDBP01572

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72 kDa inositol polyphosphate 5-phosphatase

Gene Name: INPP5E

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.

P11021

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78 kDa glucose-regulated protein

Gene Name: HSPA5

P12998

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8-amino-7-oxononanoate synthase

Gene Name: bioF

Involved in 8-amino-7-oxononanoate synthase activity. Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide.

Q7XJM2

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9-cis-beta-carotene 9',10'-cleavage dioxygenase

Gene Name: CCD7

9-cis-beta-carotene 9',10'-cleavage dioxygenase is also known as carotenoid cleavage dioxygenase 7 (CCD7). The enzyme is located in the chloroplast and catalyzes the second reaction in the 5-deoxystrigol biosynthesis whereby 9-cis-beta-carotene is converted to 9-cis-10'-apo-beta-carotenal. It requires Fe2+ as a cofactor.

P77390

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[Citrate [pro-3S]-lyase] ligase

Gene Name: citC

Involved in [citrate (pro-3S)-lyase] ligase activity. Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

Q15118

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HMDBP01172

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[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

Gene Name: PDK1

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism

P30860

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ABC transporter arginine-binding protein 1

Gene Name: artJ

Involved in transporter activity. Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Binds L-arginine with high affinity.

DB00054

View in DrugBank

Abciximab

Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor and other adhesive molecules.

Q949P1

View in UniProt

abscisic acid 8'-hydroxylase / abscisic acid 9'-hydroxylase 1

Gene Name: CYP707A1

Abscisic acid 8'-hydroxylase / abscisic acid 9'-hydroxylase is a membrane-associated enzyme that catalyzes reactions in the phaseic acid and neophaseic acid biosynthesis pathways whereby abscisic acid is converted into 8'-hydroxyabscisate and 9'-hydroxyabscisate. In Arabidopsis thaliana, this enzyme is encoded by 4 differentially expressed genes (CYP707A1, CYP707A2, CYP707A3, and CYP707A4).

Q9SE50

View in UniProt

abscisic acid glucose ester beta-glucosidase

Gene Name: BG1

Abscisic acid glucose ester beta-glucosidase is an enzyme in the endoplasmic reticulum body that catalyzes a reaction in abscisic acid glucose ester metabolism whereby abscisic acid glucose ester reforms abscisic acid. It is theorized that ABA-GE transporters are required for this enzyme to access its substrates from the cytosol. In Arabidopsis thaliana, abscisic acid glucose ester beta-glucosidase is encoded by 2 differentially expressed genes (BG1, BG2).

Q9LR44

View in UniProt

abscisic acid glucosyltransferase

Gene Name: UGT75B1

Abscisic acid glucosyltransferase is an enzyme in the cytosol that catalyzes a reaction in abscisic acid glucose ester metabolism whereby abscisic acid becomes abscisic acid glucose ester. In Arabidopsis thaliana, there appears to be several different genes encoding this protein.

P77580

View in UniProt

Acetaldehyde dehydrogenase

Gene Name: mhpF

Involved in acetaldehyde dehydrogenase (acetylating) activity. Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of mhpE.

P76458

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Acetate CoA-transferase subunit alpha

Gene Name: atoD

Involved in CoA-transferase activity. Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

P76459

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Acetate CoA-transferase subunit beta

Gene Name: atoA

Involved in CoA-transferase activity. Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.

P0A6A3

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Acetate kinase

Gene Name: ackA

Involved in kinase activity. Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically.

Q01574

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acetate--CoA ligase 1

Gene Name: ACS1

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate.

P52910

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acetate--CoA ligase ACS2

Gene Name: ACS2

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass.

P08142

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Acetolactate synthase isozyme 1 large subunit

Gene Name: ilvB

Involved in magnesium ion binding. 2 pyruvate = 2-acetolactate + CO(2).

P0ADF8

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Acetolactate synthase isozyme 1 small subunit

Gene Name: ilvN

Involved in amino acid binding. 2 pyruvate = 2-acetolactate + CO(2).

P00892

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Acetolactate synthase isozyme 2 large subunit

Gene Name: ilvG

Amino acid transport and metabolism. Catalyzes the first step in the biosynthesis of branched-chain amino acids.

P0ADG1

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Acetolactate synthase isozyme 2 small subunit

Gene Name: ilvM

Involved in acetolactate synthase activity. 2 pyruvate = 2-acetolactate + CO(2).

P00893

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Acetolactate synthase isozyme 3 large subunit

Gene Name: ilvI

Involved in magnesium ion binding. 2 pyruvate = 2-acetolactate + CO(2).

P00894

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Acetolactate synthase isozyme 3 small subunit

Gene Name: ilvH

Involved in acetolactate synthase activity. 2 pyruvate = 2-acetolactate + CO(2).

P76461

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Acetyl-CoA acetyltransferase

Gene Name: atoB

Q9BWD1

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HMDBP00013

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Acetyl-CoA acetyltransferase, cytosolic

Gene Name: ACAT2

P24752

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HMDBP00038

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Acetyl-CoA acetyltransferase, mitochondrial

Gene Name: ACAT1

Plays a major role in ketone body metabolism.

P41338

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acetyl-CoA C-acetyltransferase

Gene Name: ERG10

Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids.

Q00955

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Acetyl-CoA carboxylase

Gene Name: ACC1

Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.

Q00955

View in UniProt

Acetyl-CoA carboxylase

Gene Name: ACC1

Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.

Q00955

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Acetyl-CoA carboxylase

Gene Name: ACC1

Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.

Q13085

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HMDBP00047

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Acetyl-CoA carboxylase 1

Gene Name: ACACA

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

P32316

View in UniProt

acetyl-CoA hydrolase

Gene Name: ACH1

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis.

B1IQF6

View in UniProt

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene Name: accA

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.

P0ABD5

View in UniProt

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene Name: accA

Involved in acetyl-CoA carboxylase activity. Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.

P0A9Q5

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Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene Name: accD

Involved in acetyl-CoA carboxylase activity. Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity.

P27550

View in UniProt

Acetyl-coenzyme A synthetase

Gene Name: acs

Involved in acetate-CoA ligase activity. Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

Q9NUB1

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HMDBP00042

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Acetyl-coenzyme A synthetase 2-like, mitochondrial

Gene Name: ACSS1

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).

Q9NR19

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HMDBP00037

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Acetyl-coenzyme A synthetase, cytoplasmic

Gene Name: ACSS2

Activates acetate so that it can be used for lipid synthesis or for energy generation.

P22303

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HMDBP00524

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Acetylcholinesterase

Gene Name: ACHE

Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.

P0A6C8

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Acetylglutamate kinase

Gene Name: argB

Involved in acetylglutamate kinase activity. ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate.

P18544

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Acetylornithine aminotransferase, mitochondrial

Gene Name: ARG8

P18544

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Acetylornithine aminotransferase, mitochondrial

Gene Name: ARG8

Showing 201 - 250 of 2719 proteins