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Proteins

Showing 201 - 250 of 3625 proteins
ID Protein Pathways

P0ABR5

View in UniProt

3-phenylpropionate/cinnamic acid dioxygenase subunit alpha

Gene Name: hcaE

Involved in iron ion binding. Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.

Q47140

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3-phenylpropionate/cinnamic acid dioxygenase subunit beta

Gene Name: hcaF

Involved in 3-phenylpropionate dioxygenase activity. Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.

O15530

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HMDBP01430

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3-phosphoinositide-dependent protein kinase 1

Gene Name: PDPK1

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development. Isoform 3 is catalytically inactive

P0A6D3

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3-phosphoshikimate 1-carboxyvinyltransferase

Gene Name: aroA

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups. Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.

P19925

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4'-phosphopantetheinyl transferase entD

Gene Name: entD

Involved in magnesium ion binding. Catalyzes the transfer of the 4'-phosphopantetheine moiety from coenzyme A to apo-domains of both entB (an ArCP domain) and entF (a PCP domain). Plays an essential role in the assembly of the enterobactin.

P15977

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4-alpha-glucanotransferase

Gene Name: malQ

Involved in 4-alpha-glucanotransferase activity. Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.

P56258

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4-alpha-L-fucosyltransferase

Gene Name: wecF

Involved in fucosyltransferase activity. Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.

P22256

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4-aminobutyrate aminotransferase

Gene Name: gabT

Involved in 4-aminobutyrate transaminase activity. 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

P17649

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4-aminobutyrate aminotransferase

Gene Name: UGA1

Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance. Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2. Cannot transaminate beta-alanine (BAL).

P80404

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HMDBP00248

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4-aminobutyrate aminotransferase, mitochondrial

Gene Name: ABAT

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

P50457

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4-aminobutyrate aminotransferase_

Gene Name: puuE

Involved in 4-aminobutyrate transaminase activity. Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate.

Q9S777

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4-coumarate coenzyme A ligase 3

Gene Name: 4CL3

4-coumarate coenzyme A ligase (4CL), located in the cytosol, catalyzes the third reaction in the flavonoid biosynthesis whereby 4-coumarate is converted to 4-coumaroyl-CoA using ATP as an energy source. In Arabidopsis thaliana, although 4CL is encoded by four differentially expressed genes (4CL1, 4CL2, 4CL3, 4CL4), 4CL3 is predicted to be involved in flavonoid biosynthesis. 4CL1 and 4CL2 are theorized to take part in lignin production and 4CL4 is likely to have a different function considering that it prefers a different substrate.

Q46938

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4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

Gene Name: kduI

Involved in 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity. 4-deoxy-L-threo-5-hexosulose uronate = 3- deoxy-D-glycero-2,5-hexodiulosonate.

P62615

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4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene Name: ispE

Involved in ATP binding. Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate.

P51020

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4-hydroxy-2-oxovalerate aldolase

Gene Name: mhpE

Involved in 4-hydroxy-2-oxovalerate aldolase activity. Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of 3-phenylpropanoate.

P62620

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4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

Gene Name: ispG

Involved in catalytic activity. Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

P62623

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4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Gene Name: ispH

Involved in isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway. Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with relA to maintain it in an inactive form during normal growth.

O80574

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4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic

Gene Name: DAPB1

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Q8LB01

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4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic

Gene Name: DAPB2

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Q9LZX6

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4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic

Gene Name: DHDPS1

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Q9FVC8

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4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic

Gene Name: DHDPS2

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

P0AGK1

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4-hydroxybenzoate octaprenyltransferase

Gene Name: ubiA

Involved in prenyltransferase activity. Synthesis of 3-octaprenyl-4-hydroxybenzoate.

Q96H96

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HMDBP03700

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4-hydroxybenzoate polyprenyltransferase, mitochondrial

Gene Name: COQ2

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.

P93836

View in UniProt

4-hydroxyphenylpyruvate dioxygenase

Gene Name: PDS1

4-hydroxyphenylpyruvate dioxygenase is an enzyme in the cytosol that catalyzes a reaction in the plastoquinol-9 biosynthesis pathway whereby 4-hydroxyphenylpyruvate is converted into homogentisate. 4-hydroxyphenylpyruvate dioxygenase is a homodimer and requires Fe2+ as a cofactor.

P93836

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4-hydroxyphenylpyruvate dioxygenase

Gene Name: HPD

P32754

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HMDBP00841

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4-hydroxyphenylpyruvate dioxygenase

Gene Name: HPD

Key enzyme in the degradation of tyrosine.

P19624

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4-hydroxythreonine-4-phosphate dehydrogenase

Gene Name: pdxA

Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity. Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).

K4D5C2

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4-nitrophenylphosphatase

Gene Name: Solyc11g008620.1

P49189

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HMDBP00291

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4-trimethylaminobutyraldehyde dehydrogenase

Gene Name: ALDH9A1

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

P08195

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HMDBP03090

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4F2 cell-surface antigen heavy chain

Gene Name: SLC3A2

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier

Q8TCD5

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HMDBP00006

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5'(3')-deoxyribonucleotidase, cytosolic type

Gene Name: NT5C

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Q07938

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5'-methylthioadenosine phosphorylase

Gene Name: MEU1

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene.

P21589

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HMDBP00001

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5'-nucleotidase

Gene Name: NT5E

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

P0AEZ1

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5,10-methylenetetrahydrofolate reductase

Gene Name: metF

Involved in methylenetetrahydrofolate reductase (NADPH) activity. 5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H.

P17643

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HMDBP02139

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5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene Name: TYRP1

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized

P09950

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5-aminolevulinate synthase, mitochondrial

Gene Name: HEM1

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

P09950

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5-aminolevulinate synthase, mitochondrial

Gene Name: HEM1

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

P13196

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HMDBP00022

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5-aminolevulinate synthase, nonspecific, mitochondrial

Gene Name: ALAS1

Q3TYX5

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5-formyltetrahydrofolate cyclo-ligase

Gene Name: Mthfs

P49914

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HMDBP01408

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5-formyltetrahydrofolate cyclo-ligase

Gene Name: MTHFS

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.

P08908

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HMDBP02566

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5-hydroxytryptamine receptor 1A

Gene Name: HTR1A

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Q13639

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HMDBP02219

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5-hydroxytryptamine receptor 4

Gene Name: HTR4

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

P50406

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HMDBP02713

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5-hydroxytryptamine receptor 6

Gene Name: HTR6

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs

P34969

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HMDBP02268

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5-hydroxytryptamine receptor 7

Gene Name: HTR7

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

P23522

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5-keto-4-deoxy-D-glucarate aldolase

Gene Name: garL

Involved in carbon-carbon lyase activity. Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.

P25665

View in UniProt

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Gene Name: metE

Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity. Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.

O14841

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HMDBP00855

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5-oxoprolinase

Gene Name: OPLAH

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

P16692

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5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase

Gene Name: phnP

Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate.

Z0Z000

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5′-nucleotidase

Gene Name: ?

5′-nucleotidase is a predicted enzyme in the cytosol that is theorized to catalyze a reaction in the AMP degradation pathway whereby IMP is converted into inosine.

P50861

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6,7-dimethyl-8-ribityllumazine synthase

Gene Name: RIB4

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Showing 201 - 250 of 3625 proteins