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Proteins

Showing 1 - 50 of 2719 proteins
ID Protein Pathways

Q202I0

View in UniProt

Zeta-carotene desaturase

Gene Name: ZDS

Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.

Q92536

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HMDBP09098

View in HMDB

Y+L amino acid transporter 2

Gene Name: SLC7A6

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells

Q9UM01

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HMDBP03080

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Y+L amino acid transporter 1

Gene Name: SLC7A7

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes

P42826

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Xylulose kinase

Gene Name: XKS1

P09099

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Xylulose kinase

Gene Name: xylB

Involved in phosphotransferase activity, alcohol group as acceptor. ATP + D-xylulose = ADP + D-xylulose 5- phosphate.

P0AGI4

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Xylose transport system permease protein xylH

Gene Name: xylH

Involved in transporter activity. Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.

P0ACI3

View in UniProt

Xylose operon regulatory protein

Gene Name: xylR

Regulatory protein for the xylBAFGHR operon.

P00944

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Xylose isomerase

Gene Name: xylA

Involved in xylose isomerase activity. D-xylose = D-xylulose.

P37388

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Xylose import ATP-binding protein XylG

Gene Name: xylG

Involved in nucleotide binding. Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose.

Z0Z000

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xanthoxin transporter

Gene Name: ?

Xanthoxin transporter is theorized to export xanthoxin from the chloroplast into the cytosol for abscisic acid biosynthesis. It has yet to be discovered.

P45563

View in UniProt

Xanthosine phosphorylase

Gene Name: xapA

Involved in purine-nucleoside phosphorylase activity. The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except adenosine and deoxyadenosine.

P45562

View in UniProt

Xanthosine permease

Gene Name: xapB

Involved in nucleoside transmembrane transporter activity. Nucleoside transport.

P0A9M5

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Xanthine phosphoribosyltransferase

Gene Name: gpt

Involved in nucleoside metabolic process. Acts on guanine, xanthine and to a lesser extent hypoxanthine.

P47989

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HMDBP00181

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Xanthine dehydrogenase/oxidase

Gene Name: XDH

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

Q46799

View in UniProt

Xanthine dehydrogenase molybdenum-binding subunit

Gene Name: xdhA

Involved in oxidoreductase activity. Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage.

Q46801

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Xanthine dehydrogenase iron-sulfur-binding subunit

Gene Name: xdhC

Involved in oxidoreductase activity. Iron-sulfur subunit of the xanthine dehydrogenase complex.

Q46800

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Xanthine dehydrogenase FAD-binding subunit

Gene Name: xdhB

Involved in flavin adenine dinucleotide binding. Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism).

P0AB65

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weak acylphosphatase

Gene Name: yccX

O95180

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HMDBP07496

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Voltage-dependent T-type calcium channel subunit alpha-1H

Gene Name: CACNA1H

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes

O43497

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HMDBP07495

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Voltage-dependent T-type calcium channel subunit alpha-1G

Gene Name: CACNA1G

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes

O00555

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HMDBP07491

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Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Gene Name: CACNA1A

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA)

Q02641

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HMDBP07499

View in HMDB

Voltage-dependent L-type calcium channel subunit beta-1

Gene Name: CACNB1

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting

Q13936

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HMDBP02220

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Voltage-dependent L-type calcium channel subunit alpha-1C

Gene Name: CACNA1C

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function

Q9NY47

View in UniProt

HMDBP07485

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Voltage-dependent calcium channel subunit alpha-2/delta-2

Gene Name: CACNA2D2

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis

P38435

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HMDBP01691

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Vitamin K-dependent gamma-carboxylase

Gene Name: GGCX

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Q9BQB6

View in UniProt

HMDBP02242

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Vitamin K epoxide reductase complex subunit 1

Gene Name: VKORC1

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.

P37028

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Vitamin B12-binding protein

Gene Name: btuF

Involved in binding. Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.

Q8X714

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Vitamin B12 transporter BtuB

Gene Name: btuB

Involved in receptor activity. Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein tonB.

B1XG18

View in UniProt

Vitamin B12 import system permease protein BtuC

Gene Name: btuC

Involved in cobalamin transport. Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.

P06611

View in UniProt

Vitamin B12 import ATP-binding protein BtuD

Gene Name: btuD

Involved in nucleotide binding. Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.

P49748

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HMDBP08259

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Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene Name: ACADVL

Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.

P38225

View in UniProt

Very long-chain fatty acid transport protein

Gene Name: FAT1

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

O14975

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HMDBP01946

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Very long-chain acyl-CoA synthetase

Gene Name: SLC27A2

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).

P30518

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HMDBP01725

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Vasopressin V2 receptor

Gene Name: AVPR2

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase

P35968

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HMDBP01272

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Vascular endothelial growth factor receptor 2

Gene Name: KDR

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions

P17948

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HMDBP01462

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Vascular endothelial growth factor receptor 1

Gene Name: FLT1

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis

P15692

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HMDBP02130

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Vascular endothelial growth factor A

Gene Name: VEGFA

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth

P07118

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Valyl-tRNA synthetase

Gene Name: valS

Involved in nucleotide binding. Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

P09053

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Valine--pyruvate aminotransferase

Gene Name: avtA

Involved in transferase activity. L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.

P39161

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Uxu operon transcriptional regulator

Gene Name: uxuR

Repressor for the uxuRBA operon.

P54725

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UV excision repair protein RAD23 homolog A

P0AEP3

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UTP--glucose-1-phosphate uridylyltransferase_

Gene Name: galU

Involved in UTP:glucose-1-phosphate uridylyltransferase activity. May play a role in stationary phase survival.

Q16851

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HMDBP01074

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UTP--glucose-1-phosphate uridylyltransferase

Gene Name: UGP2

Plays a central role as a glucosyl donor in cellular metabolic pathways.

P09126

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Uroporphyrinogen-III synthase

Gene Name: hemD

Involved in uroporphyrinogen-III synthase activity. Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

P10746

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HMDBP00357

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Uroporphyrinogen-III synthase

Gene Name: UROS

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).

P06132

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HMDBP00250

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Uroporphyrinogen decarboxylase

Gene Name: UROD

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

P29680

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Uroporphyrinogen decarboxylase

Gene Name: hemE

Involved in uroporphyrinogen decarboxylase activity. Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

P0A8G3

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Uronate isomerase

Gene Name: uxaC

Involved in glucuronate isomerase activity. D-glucuronate = D-fructuronate.

DB00013

View in DrugBank

Urokinase

Q96N76

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HMDBP00914

View in HMDB

Urocanate hydratase

Gene Name: UROC1

Showing 1 - 50 of 2719 proteins