PW000226
PathWhiz
ReactionCatalysis169328
ACTIVATION
BiologicalState661
Homo sapiens, Lung, Epithelial Cell
Transport10328
false
Angiotensin-converting enzyme (→) Transport: Homo sapiens, Lung, Epithelial Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
Enalaprilat
BiologicalState29
Homo sapiens, Liver
Unknown
Angiotensin I
3081372
PubChem-compound
4534998
ChemSpider
C11720
KEGG Compound
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(O)=O
Enalaprilat inhibition of ACE
InhibitorySubPathway
HMDB0041886
HMDB
Angiotensinogen
Angiotensin-converting enzyme
5292946
ChemSpider
BTO:0001102
BRENDA TISSUE ONTOLOGY
Lung
BTO:0000759
BRENDA TISSUE ONTOLOGY
SMP0000148
SMPDB
Transport130
false
Enalaprilat (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Homo sapiens
CL:0000066
CELL TYPE ONTOLOGY
Renin
ReactionCatalysis1348
ACTIVATION
BTO:0000763
BRENDA TISSUE ONTOLOGY
Transport136
false
Angiotensinogen (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
C62H89N17O14
Angiotensin I
1295.6775
Transport135
false
Renin (→) Transport: Homo sapiens, Kidney to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
1.0
HMDB0014722
HMDB
CHEBI:2719
ChEBI
172198
PubChem-compound
C20H28N2O5
Enalapril
376.19983
HMDB0061196
HMDB
C50H71N13O12
Angiotensin II
1045.5345
2338989
ChemSpider
Angiotensin-converting enzyme
SubPathwayInhibition
Epithelial Cell
Enalapril
9606
TAXONOMY
Angiotensin II
3.4.23.15
false
3.4.23.15
Angiotensinogen → Angiotensin I + des(AngI)AGT
LEFT_TO_RIGHT
4474-91-3
CAS
Angiotensinogen
76420-72-9
CAS
C06977
KEGG Compound
C00873
KEGG Compound
Kidney
C02135
KEGG Compound
1.0
Angiotensin-converting enzyme
P00797
UniProt
C18H24N2O5
Enalaprilat
348.16852
Unknown
SMILES
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O
P12821
UniProt
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
Reaction1606
false
Angiotensin I → Angiotensin II
LEFT_TO_RIGHT
CHEBI:59877
ChEBI
1.0
Liver
HMDB0001035
HMDB
Enalaprilat
SubPathwayInhibitor
1.0
1.0
Renin
75847-73-3
CAS
1.0
P01019
UniProt
150504
ChemSpider
SubPathwayControl404
SubPathway404Control
InhibitorySubPathwayControl
Extracellular Space
Blood Vessel
6917719
PubChem-compound
BiologicalState51
Homo sapiens, Blood Vessel
1.0
Reaction1599
false
Enalapril → Enalaprilat
LEFT_TO_RIGHT
9041-90-1 484-42-4
CAS
1.0
40466924
PubChem-compound
SMILES
[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@@]1([H])C(O)=O
BTO:0000671
BRENDA TISSUE ONTOLOGY
GO:0005615
GENE ONTOLOGY
CHEBI:4784
ChEBI
BiologicalState63
Homo sapiens, Kidney
1.0
Enalapril Action Pathway