Angiotensin-
converting
enzyme
Renin
Angiotensin-
converting
enzyme
Angiotensinogen
Renin
Angiotensin-
converting
enzyme
Angiotensinogen
des(AngI)AGT
Perindoprilat
Perindoprilat
Perindopril
Perindoprilat glucuronide
Zinc (II) ion
Chloride ion
Angiotensin I
Angiotensin II
H2O
Na+
H2O
K+
H+
Zinc (II) ion
Chloride ion
Zinc (II) ion
Chloride ion
Angiotensin-
converting
enzyme
Angiotensin II
Aldosterone
Angiotensin II
H2O
Vasopressin
From liver
From kidney
Into circulation
From capillaries of lungs
and endothelial cells of
kidney
Hypothalmus
Posterior Pituitary Gland
Angiotensin II binds
directly to AT1 receptors on
the smooth muscle cells of
the tunica media layer to
induce vasoconstriction of
the blood vessel
Adrenal Cortex
Vasopressin is released from
the posterior pituitary
gland where it changes the
permeability of the
collecting ducts to allow
for water reabsorption back
into the blood circulation
Water reabsorption into
blood circulation
Increase in blood pressure
Increase in circulating
blood volume
Triggers thirst sensation
Increase in oral water
uptake
Reabsorption of Na+ into the
blood stream subsequently
causes water to follow, thus
water retention occurs
Potassium and hydrogen ions
are simultaneously excreted
into the urine
Angiotensin binds to
receptors in the adrenal
cortex to trigger a series
of reactions that leads to
the synthesis of aldosterone
from cholesterol