9606
TAXONOMY
Angiotensin II
3.4.23.15
false
3.4.23.15
Angiotensinogen → Angiotensin I + des(AngI)AGT
LEFT_TO_RIGHT
ReactionCatalysis169328
ACTIVATION
Spiraprilat
SubPathwayInhibitor
4474-91-3
CAS
Angiotensinogen
BiologicalState661
Homo sapiens, Lung, Epithelial Cell
Transport10328
false
Angiotensin-converting enzyme (→) Transport: Homo sapiens, Lung, Epithelial Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
C00873
KEGG Compound
Kidney
C02135
KEGG Compound
BiologicalState29
Homo sapiens, Liver
Angiotensin-converting enzyme
SubPathwayInhibition
Unknown
Angiotensin I
P00797
UniProt
3081372
PubChem-compound
Transport234
false
Spiraprilat (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
Spirapril Action Pathway
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(O)=O
Unknown
SMILES
C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CC2(C[C@H]1C(O)=O)SCCS2
P12821
UniProt
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
Reaction1727
false
Spirapril → Spiraprilat
LEFT_TO_RIGHT
Reaction1606
false
Angiotensin I → Angiotensin II
LEFT_TO_RIGHT
HMDB0015438
HMDB
Angiotensinogen
4470933
ChemSpider
SubPathwayControl538
SubPathway538Control
InhibitorySubPathwayControl
Angiotensin-converting enzyme
1.0
Liver
HMDB0001035
HMDB
BTO:0001102
BRENDA TISSUE ONTOLOGY
SMILES
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2(C[C@H]1C(O)=O)SCCS2
Renin
Lung
1.0
P01019
UniProt
spiraprilat inhibition of ACE
InhibitorySubPathway
BTO:0000759
BRENDA TISSUE ONTOLOGY
HMDB0061261
HMDB
150504
ChemSpider
Homo sapiens
CL:0000066
CELL TYPE ONTOLOGY
Renin
2298317
ChemSpider
Blood Vessel
ReactionCatalysis1348
ACTIVATION
40479741
PubChem-compound
1.0
BiologicalState51
Homo sapiens, Blood Vessel
1.0
BTO:0000763
BRENDA TISSUE ONTOLOGY
Transport136
false
Angiotensinogen (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
C62H89N17O14
Angiotensin I
1295.6775
Transport135
false
Renin (→) Transport: Homo sapiens, Kidney to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
83647-97-6
CAS
9041-90-1 484-42-4
CAS
1.0
1.0
C20H26N2O5S2
Spiraprilat
438.12833
CHEBI:2719
ChEBI
172198
PubChem-compound
HMDB0061196
HMDB
PW000234
PathWhiz
C50H71N13O12
Angiotensin II
1045.5345
C22H30N2O5S2
Spirapril
466.1596
BTO:0000671
BRENDA TISSUE ONTOLOGY
CHEBI:101967
ChEBI
Spirapril
2338989
ChemSpider
1.0
BiologicalState63
Homo sapiens, Kidney
3033702
PubChem-compound
Epithelial Cell
SMP0000156
SMPDB
1.0