Guanosine diphosphate
Gβ
ReactionCatalysis169328
ACTIVATION
BiologicalState661
Homo sapiens, Lung, Epithelial Cell
Transport10328
false
Angiotensin-converting enzyme (→) Transport: Homo sapiens, Lung, Epithelial Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
C07467
KEGG Compound
Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens)_Type-1 angiotensin II receptor (Homo sapiens)
C00035
KEGG Compound
BiologicalState29
Homo sapiens, Liver
direct_interaction
Unknown
Angiotensin I
Eprosartan Action Pathway
3081372
PubChem-compound
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(O)=O
P30556
UniProt
Angiotensinogen
Guanine nucleotide-binding protein G(q) subunit alpha
Angiotensin-converting enzyme
BTO:0001102
BRENDA TISSUE ONTOLOGY
Lung
P59768
UniProt
BTO:0000759
BRENDA TISSUE ONTOLOGY
Homo sapiens
CL:0000066
CELL TYPE ONTOLOGY
Gγ
SubPathwayControl448
InhibitorySubPathwayControl
SubPathway448Control
Renin
Eprosartan
SubPathwayInhibitor
ReactionCatalysis1348
ACTIVATION
1.0
Type-1 angiotensin II receptor
SubPathwayInhibition
BTO:0000763
BRENDA TISSUE ONTOLOGY
Transport136
false
Angiotensinogen (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
C62H89N17O14
Angiotensin I
1295.6775
Transport135
false
Renin (→) Transport: Homo sapiens, Kidney to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
1.0
CHEBI:2719
ChEBI
172198
PubChem-compound
HMDB0061196
HMDB
SMP0000159
SMPDB
PW000279
PathWhiz
Guanine nucleotide-binding protein G(q) subunit alpha
8977
PubChem-compound
C50H71N13O12
Angiotensin II
1045.5345
C10H15N5O11P2
Guanosine diphosphate
443.02432
HMDB0015014
HMDB
2338989
ChemSpider
Epithelial Cell
133040-01-4
CAS
9606
TAXONOMY
Angiotensin II
3.4.23.15
false
3.4.23.15
Angiotensinogen → Angiotensin I + des(AngI)AGT
LEFT_TO_RIGHT
P62873
UniProt
4474-91-3
CAS
Angiotensinogen
8630
ChemSpider
Gγ
C00873
KEGG Compound
Kidney
C02135
KEGG Compound
Angiotensin-converting enzyme
C23H24N2O4S
Eprosartan
424.1457
GO:0005886
GENE ONTOLOGY
P00797
UniProt
Cell Membrane
Eprosartan inhibition of Type-1 angiotensin II receptor
InhibitorySubPathway
Unknown
SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O
P12821
UniProt
Reaction1606
false
Angiotensin I → Angiotensin II
LEFT_TO_RIGHT
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
1.0
Liver
HMDB0001035
HMDB
Interaction2848
Angiotensin II activates Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) + Type-1 angiotensin II receptor (Homo sapiens)
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
P50148
UniProt
Renin
1.0
P01019
UniProt
4444504
ChemSpider
1.0
150504
ChemSpider
1.0
Gβγ
HMDB0001201
HMDB
Blood Vessel
SMILES
CCCCC1=NC=C(\C=C(/CC2=CC=CS2)C(O)=O)N1CC1=CC=C(C=C1)C(O)=O
5281037
PubChem-compound
BiologicalState51
Homo sapiens, Blood Vessel
1.0
CHEBI:4814
ChEBI
9041-90-1 484-42-4
CAS
1.0
Gβ
Type-1 angiotensin II receptor
BTO:0000671
BRENDA TISSUE ONTOLOGY
1.0
146-91-8
CAS
Angiotensin II
BiologicalState63
Homo sapiens, Kidney
1.0