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CHEBI:16015 ChEBI 6022 PubChem-compound 7722-84-1 CAS 1.0 Histidine--tRNA ligase, cytoplasmic C00439 KEGG Compound 937 ChemSpider L-Histidine CHEBI:16134 ChEBI Carnosine 1.0 HMDB0003125 HMDB 439153 PubChem-compound Amiloride-sensitive amine oxidase [copper-containing] 1.0 Tetrahydrofolic acid HMDB0001185 HMDB CHEBI:27398 ChEBI CHEBI:20506 ChEBI 2.0 L-Histidyl-tRNA(His) CHEBI:16027 ChEBI Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial ATP BioCyc CHEBI:18323 ChEBI 388363 ChemSpider C6H11N3 1-Methylhistamine 125.0953 Q96N76 UniProt 18714427 ChemSpider 559142 ChemSpider SMILES CN1C=NC(CC=O)=C1 CHEBI:27384 ChEBI 1.0 C6H8N2O3 4-Imidazolone-5-propionic acid 156.0535 C15H23N6O5S S-Adenosylmethionine 399.14505 Histamine 1.0 ReactionCatalysis62987 ACTIVATION ReactionCatalysis62986 ACTIVATION 1.0 100482 ChemSpider ReactionCatalysis62988 ACTIVATION 5742 ChemSpider 17340-16-8 CAS CHEBI:16474 ChEBI 952 ChemSpider CHEBI:28104 ChEBI Carbon dioxide Aldehyde dehydrogenase, mitochondrial Formimidoyltransferase-cyclodeaminase Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase [flavin-containing] A Carnosine synthase 1 64969 PubChem-compound 5858 ChemSpider 6274 PubChem-compound Adenosine monophosphate CHEBI:16240 ChEBI 4-IMIDAZOLONE-5-PROPIONATE BioCyc 1.0 Carnosine synthase 1 58494 ChemSpider 1010 ChemSpider C00101 KEGG Compound Carnosine PPI BioCyc Imidazoleacetic acid 1.0 643824 ChemSpider 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 979-92-0 CAS L-Glutamic acid SubPathwayInput Cytosol C6H8N2O2 Methylimidazoleacetic acid 140.05858 SMILES OC(=O)CCC1N=CNC1=O C14H20N6O5S S-Adenosylhomocysteine 384.12158 Q96NU7 UniProt A5YM72 UniProt P50135 UniProt Carnosine N-methyltransferase 1.4.3.4 false 1.4.3.4 1-Methylhistamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Methylimidazole acetaldehyde LEFT_TO_RIGHT Urocanic acid cytosolic non-specific dipeptidase 3-Methylhistidine 193545 PubChem-compound C00009 KEGG Compound C00008 KEGG Compound CHEBI:1606 ChEBI C00007 KEGG Compound 19639-03-3 CAS C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound CHEBI:7274 ChEBI 1032 ChemSpider C00003 KEGG Compound 135-16-0 CAS C00002 KEGG Compound NADP Q96KN2 UniProt 1.0 CHEBI:29009 ChEBI 4.0 1.0 C00019 KEGG Compound 3488 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 C05828 KEGG Compound C05827 KEGG Compound Adenosine triphosphate C00011 KEGG Compound HMDB0000902 HMDB Formimidoyltransferase-cyclodeaminase C00135 KEGG Compound C00014 KEGG Compound C00013 KEGG Compound 1-Methylhistidine NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 388301 ChemSpider Beta-Ala-His dipeptidase C00386 KEGG Compound 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS C00020 KEGG Compound C00027 KEGG Compound C00388 KEGG Compound C00025 KEGG Compound Q96KP4 UniProt 501-75-7 CAS 104-98-3 CAS 8.0 Carnosine synthase 1 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P19801 UniProt 1.0 HYDROGEN-PEROXIDE BioCyc 645-65-8 CAS CHEBI:29178 ChEBI HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB P49590 UniProt 1.0 132948 ChemSpider P30838 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C03680 KEGG Compound 763 ChemSpider C01262 KEGG Compound HMDB0000148 HMDB Histamine L-Histidyl-tRNA(His) 1.0 tRNA(His) C6H10N2O4 Formiminoglutamic acid 174.06406 784 PubChem-compound 7732-18-5 CAS HMDB0001487 HMDB 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C01152 KEGG Compound 3614 PubChem-compound AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Adenosine diphosphate CHEBI:29155 ChEBI HMDB0000033 HMDB 774 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Probable histidine--tRNA ligase, mitochondrial Protein arginine N-methyltransferase 3 Beta-Ala-His dipeptidase 530 PubChem-compound Pyrophosphate HMDB0001377 HMDB HMDB0001014 HMDB P12081 UniProt HMDB0000045 HMDB S-Adenosylhomocysteine 1.0 1.0 C5H6N2O Imidazole-4-acetaldehyde 110.04801 83153 ChemSpider Ammonia SMILES NCCC(O)=O UROCANATE BioCyc Amiloride-sensitive amine oxidase [copper-containing] 962 PubChem-compound 31983 ChemSpider 86856 ChemSpider 5800 ChemSpider Histidinemia CO2 Carbon dioxide 43.98983 Hydrogen peroxide HMDB0000056 HMDB HMDB0000177 HMDB C00080 KEGG Compound SMILES O=O Histidine ammonia-lyase Glutamate Metabolism SubPathway HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 14265-44-2 CAS Probable histidine--tRNA ligase, mitochondrial C6H9N3O2 L-Histidine 155.06947 58-64-0 CAS HISTAMINE BioCyc Aldehyde dehydrogenase, dimeric NADP-preferring C7H11N3O2 3-Methylhistidine 169.08513 C7H11N3O2 1-Methylhistidine 169.08513 644102 PubChem-compound C6H6N2O2 Urocanic acid 138.04292 6083 PubChem-compound 1.0 Carnosine N-methyltransferase C00099 KEGG Compound Histidine ammonia-lyase CHEBI:18295 ChEBI 25246222 PubChem-compound 753 ChemSpider 22833512 PubChem-compound CARNOSINE BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 HMDB0000194 HMDB C5H9N3 Histamine 111.07965 NADH BioCyc 5-Formiminotetrahydrofolic acid NAD BioCyc 977 PubChem-compound HMDB0059597 HMDB Histamine N-methyltransferase 332-80-9 CAS 1.0 Formimidoyltransferase-cyclodeaminase 167957 ChemSpider SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 NAD HMDB0002024 HMDB ReactionCatalysis157 ACTIVATION 30572 ChemSpider 17215925 ChemSpider Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial 128 PubChem-compound tRNA(His) C5H6N2O2 Imidazoleacetic acid 126.04293 L-Histidyl-tRNA(His) SMILES OC(=O)\C=C\C1=CNC=N1 Histidine decarboxylase SMILES NCCC1=CNC=N1 1.0 1.0 SMILES O HMDB0000898 HMDB SMILES OO 1.0 H3N Ammonia 17.026548 6.1.1.21 false 6.1.1.21 Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + L-Histidyl-tRNA(His) + Pyrophosphate LEFT_TO_RIGHT C10H14N5O7P Adenosine monophosphate 347.06308 Q8N4J0 UniProt 1.0 CHEBI:15971 ChEBI 1.0 239 PubChem-compound 4.3.1.3 false 4.3.1.3 L-Histidine ↔ Ammonia + Urocanic acid REVERSIBLE HMDB0000538 HMDB 1.0 2.0 HMDB0000301 HMDB 125 ChemSpider Water CHEBI:15846 ChEBI CHEBI:15727 ChEBI ADP BioCyc C3H7NO2 beta-Alanine 89.047676 28305488 PubChem-compound 53-59-8 CAS Probable histidine--tRNA ligase, mitochondrial C10H16N4O3 Anserine 240.12224 1.0 6038 ChemSpider 1038 PubChem-compound GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 274 ChemSpider 1.0 beta-Alanine CHEBI:16908 ChEBI Imidazole-4-acetaldehyde 2.1.1.- false 2.1.1.- L-Histidine + S-Adenosylmethionine → 3-Methylhistidine + S-Adenosylhomocysteine LEFT_TO_RIGHT Ammonia ADENOSYL-HOMO-CYS BioCyc cytosolic non-specific dipeptidase SubPathwayInteraction845 SubPathway845Reaction SubPathwayReaction Methylimidazole acetaldehyde O4P Phosphate 94.95342 485-80-3 CAS Urocanate hydratase 305-84-0 CAS Histidine--tRNA ligase, cytoplasmic 1.0 SMILES OC(=O)CC[C@H](NC=N)C(O)=O Adenosine triphosphate HMDB0001534 HMDB C21H30N7O17P3 NADPH 745.0911 C9H14N4O3 Carnosine 226.1066 3.4.13.20 false 3.4.13.20 Carnosine + Water → L-Histidine + beta-Alanine LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Mitochondrion THF BioCyc N-FORMIMINO-L-GLUTAMATE BioCyc NADPH BioCyc CHEBI:16974 ChEBI 1.0 S-Adenosylhomocysteine CPD-6641 BioCyc SMILES CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O 71-00-1 CAS Probable imidazolonepropionase C05127 KEGG Compound 217 ChemSpider O95954 UniProt 58-68-4 CAS SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 SMILES [O-]P([O-])([O-])=O HMDB0000217 HMDB 1.0 C05130 KEGG Compound 124-38-9 CAS CHEBI:15639 ChEBI CHEBI:15414 ChEBI tRNA(His) HMDB0001429 HMDB 1.4.3.22 false 1.4.3.22 Histamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Imidazole-4-acetaldehyde LEFT_TO_RIGHT SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES OC(=O)CC1=CN=CN1 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 1.0 SMILES NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O 7664-41-7 CAS GLT BioCyc 107-95-9 CAS Oxygen 53-57-6 CAS S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O 1-Methylhistamine 222 PubChem-compound O7P2 Pyrophosphate 173.91193 234 ChemSpider HMDB0000479 HMDB Hydrogen peroxide C21H29N7O14P2 NADH 665.12476 P21397 UniProt 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1.0 Reaction869 false Formiminoglutamic acid + Tetrahydrofolic acid ↔ 5-Formiminotetrahydrofolic acid + L-Glutamic acid REVERSIBLE 4.2.1.49 false 4.2.1.49 4-Imidazolone-5-propionic acid ↔ Urocanic acid + Water REVERSIBLE 4.0 SMILES N[C@@H](CC1=CN=CN1)C(O)=O 1.0 816-90-0 CAS SMP0000072 SMPDB Amiloride-sensitive amine oxidase [copper-containing] HMDB0000001 HMDB SMP0000191 SMPDB GO:0005739 GENE ONTOLOGY Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY SMILES CN1C=NC=C1C[C@H](N)C(O)=O SMILES CN1C=NC(C[C@H](N)C(O)=O)=C1 CHEBI:16958 ChEBI 1.0 Imidazole-4-acetaldehyde 2.0 NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 51-45-6 CAS L-Histidine 5682 ChemSpider Beta-Ala-His dipeptidase 2.0 Carnosine synthase 1 1.0 14000-31-8 CAS HMDB0004181 HMDB 1.0 P05091 UniProt B-ALANINE BioCyc 5675 ChemSpider N-METHYL-HISTAMINE BioCyc 68319 ChemSpider S-Adenosylmethionine HMDB0000939 HMDB Adenosine diphosphate 1.0 Cytoplasm 1.2.1.5 false 1.2.1.5 Methylimidazole acetaldehyde + NADP + Water → Hydrogen Ion + Methylimidazoleacetic acid + NADPH LEFT_TO_RIGHT 150841 PubChem-compound Urocanate hydratase NADPH ReactionCatalysis454 ACTIVATION ReactionCatalysis455 ACTIVATION cytosolic non-specific dipeptidase ReactionCatalysis452 ACTIVATION CHEBI:15422 ChEBI ReactionCatalysis453 ACTIVATION 584-85-0 CAS ReactionCatalysis450 ACTIVATION ReactionCatalysis451 ACTIVATION Homo sapiens 388299 ChemSpider Protein arginine N-methyltransferase 3 1.0 Hydrogen Ion O2 Oxygen 31.98983 O60678 UniProt CHEBI:30817 ChEBI 1.0 ReactionCatalysis449 ACTIVATION HIS BioCyc ReactionCatalysis448 ACTIVATION 1.2.1.3 false 1.2.1.3 Imidazole-4-acetaldehyde + NAD + Water → Hydrogen Ion + Imidazoleacetic acid + NADH LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound SMILES CN1C=NC(CCN)=C1 Probable imidazolonepropionase CHEBI:16526 ChEBI Adenosine monophosphate Histidine--tRNA ligase, cytoplasmic CHEBI:50599 ChEBI CHEBI:16761 ChEBI 7782-44-7 CAS beta-Alanine Carnosine synthase 1 2.0 4-Imidazolone-5-propionic acid 1.0 9606 TAXONOMY 1.0 Formiminoglutamic acid 4-IMIDAZOLEACETATE BioCyc 1.0 1.0 5893 PubChem-compound 439233 PubChem-compound P42357 UniProt HMDB0000854 HMDB 2.1.1.8 false 2.1.1.8 Histamine + S-Adenosylmethionine → 1-Methylhistamine + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 CHEBI:27596 ChEBI 1.0 CHEBI:15377 ChEBI 368-16-1 CAS Pyrophosphate 6.3.2.11 false 6.3.2.11 Adenosine triphosphate + L-Histidine + beta-Alanine → Adenosine diphosphate + Carnosine + Phosphate LEFT_TO_RIGHT CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] Amine oxidase [flavin-containing] A 2625-49-2 CAS ReactionCatalysis460 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 1.0 Phosphate 439224 PubChem-compound Reaction72857 false Carnosine + S-Adenosylmethionine → Anserine + S-Adenosylhomocysteine LEFT_TO_RIGHT Phosphate Oxygen Reaction72858 false 1-Methylhistidine + Adenosine triphosphate + beta-Alanine → Adenosine diphosphate + Anserine + Phosphate LEFT_TO_RIGHT 3.4.13.18 false 3.4.13.18 Anserine + Water → 1-Methylhistidine + beta-Alanine LEFT_TO_RIGHT 1.0 280 PubChem-compound SMILES O=CCC1=CN=CN1 645-14-7 CAS ReactionCatalysis458 ACTIVATION 3.5.2.7 false 3.5.2.7 4-Imidazolone-5-propionic acid + Water → Formiminoglutamic acid LEFT_TO_RIGHT ReactionCatalysis459 ACTIVATION ReactionCatalysis456 ACTIVATION 736715 PubChem-compound ReactionCatalysis457 ACTIVATION ReactionCatalysis131 ACTIVATION C02835 KEGG Compound PW000003 PathWhiz SMILES CN1C=NC(CC(O)=O)=C1 Methylimidazoleacetic acid 388370 ChemSpider SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O HMDB0000870 HMDB 2311-81-1 CAS 75810 PubChem-compound 112072 PubChem-compound 4.0 4.1.1.22 false 4.1.1.22 L-Histidine → Carbon dioxide + Histamine LEFT_TO_RIGHT 1.0 1061 PubChem-compound Histamine N-methyltransferase PW000113 PathWhiz 2.0 HMDB0003905 HMDB HMDB0001967 HMDB HMDB0001846 HMDB CHEBI:16680 ChEBI C00785 KEGG Compound C00664 KEGG Compound 24762165 PubChem-compound HMDB0002820 HMDB P19113 UniProt 1.0 13781857 PubChem-compound S-Adenosylmethionine CPD-1823 BioCyc 7020397 PubChem-compound C6H8N2O Methylimidazole acetaldehyde 124.06366 Anserine Beta-Ala-His dipeptidase Carnosine synthase 1 Protein arginine N- methyltransferase 3 Histidine decarboxylase Histamine N- methyltransferase Amine oxidase [flavin- containing] A Aldehyde dehydrogenase, dimeric NADP-preferring Aldehyde dehydrogenase, mitochondrial Histidine ammonia-lyase Urocanate hydratase Probable imidazolonepropionase Formimidoyltransferase- cyclodeaminase Amiloride- sensitive amine oxidase [copper- containing] Carnosine N- methyltransferase Carnosine synthase 1 cytosolic non-specific dipeptidase Probable histidine--tRNA ligase, mitochondrial Histidine--tRNA ligase, cytoplasmic L-Glutamic acid Carnosine H 2 O beta-Alanine Accumulation L-Histidine ATP beta-Alanine ADP P i S-Adenosylmethionine 3- Methylhistidine S-Adenosylhomocysteine Histamine CO 2 S-Adenosylmethionine S-Adenosylhomocysteine 1-Methylhistamine H 2 O O 2 Methylimidazole acetaldehyde NH 3 H 2 O 2 NADP H 2 O Methylimidazoleacetic acid NADPH H + Imidazole-4-acetaldehyde NAD H 2 O Imidazoleacetic acid NADH H + NH 3 Urocanic acid 4-Imidazolone-5-propionic acid H 2 O H 2 O Formiminoglutamic acid Tetrahydrofolic acid 5-Formiminotetrahydrofolic acid H 2 O O 2 NH 3 H 2 O 2 S- Adenosylmethionine S- Adenosylhomocysteine Anserine ATP 1-Methylhistidine beta-Alanine ADP P i H 2 O beta-Alanine ATP AMP PP i ATP AMP PP i Zinc (II) ion Manganese Pyridoxal 5'-phosphate FAD NAD Zinc (II) ion Pyridoxal 5'-phosphate Copper Calcium Topaquinone tRNA(His) L- Histidyl- tRNA(His) tRNA(His) Glutamate Metabolism Manganese Manganese Intracellular Space Extracellular Space
CHEBI:16015 ChEBI 6022 PubChem-compound 7722-84-1 CAS 1.0 Histidine--tRNA ligase, cytoplasmic C00439 KEGG Compound 937 ChemSpider L-Histidine CHEBI:16134 ChEBI Carnosine 1.0 HMDB0003125 HMDB 439153 PubChem-compound Amiloride-sensitive amine oxidase [copper-containing] 1.0 Tetrahydrofolic acid HMDB0001185 HMDB CHEBI:27398 ChEBI CHEBI:20506 ChEBI 2.0 L-Histidyl-tRNA(His) CHEBI:16027 ChEBI Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial ATP BioCyc CHEBI:18323 ChEBI 388363 ChemSpider C6H11N3 1-Methylhistamine 125.0953 Q96N76 UniProt 18714427 ChemSpider 559142 ChemSpider SMILES CN1C=NC(CC=O)=C1 CHEBI:27384 ChEBI 1.0 C6H8N2O3 4-Imidazolone-5-propionic acid 156.0535 C15H23N6O5S S-Adenosylmethionine 399.14505 Histamine 1.0 ReactionCatalysis62987 ACTIVATION ReactionCatalysis62986 ACTIVATION 1.0 100482 ChemSpider ReactionCatalysis62988 ACTIVATION 5742 ChemSpider 17340-16-8 CAS CHEBI:16474 ChEBI 952 ChemSpider CHEBI:28104 ChEBI Carbon dioxide Aldehyde dehydrogenase, mitochondrial Formimidoyltransferase-cyclodeaminase Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase [flavin-containing] A Carnosine synthase 1 64969 PubChem-compound 5858 ChemSpider 6274 PubChem-compound Adenosine monophosphate CHEBI:16240 ChEBI 4-IMIDAZOLONE-5-PROPIONATE BioCyc 1.0 Carnosine synthase 1 58494 ChemSpider 1010 ChemSpider C00101 KEGG Compound Carnosine PPI BioCyc Imidazoleacetic acid 1.0 643824 ChemSpider 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 979-92-0 CAS L-Glutamic acid SubPathwayInput Cytosol C6H8N2O2 Methylimidazoleacetic acid 140.05858 SMILES OC(=O)CCC1N=CNC1=O C14H20N6O5S S-Adenosylhomocysteine 384.12158 Q96NU7 UniProt A5YM72 UniProt P50135 UniProt Carnosine N-methyltransferase 1.4.3.4 false 1.4.3.4 1-Methylhistamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Methylimidazole acetaldehyde LEFT_TO_RIGHT Urocanic acid cytosolic non-specific dipeptidase 3-Methylhistidine 193545 PubChem-compound C00009 KEGG Compound C00008 KEGG Compound CHEBI:1606 ChEBI C00007 KEGG Compound 19639-03-3 CAS C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound CHEBI:7274 ChEBI 1032 ChemSpider C00003 KEGG Compound 135-16-0 CAS C00002 KEGG Compound NADP Q96KN2 UniProt 1.0 CHEBI:29009 ChEBI 4.0 1.0 C00019 KEGG Compound 3488 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 C05828 KEGG Compound C05827 KEGG Compound Adenosine triphosphate C00011 KEGG Compound HMDB0000902 HMDB Formimidoyltransferase-cyclodeaminase C00135 KEGG Compound C00014 KEGG Compound C00013 KEGG Compound 1-Methylhistidine NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 388301 ChemSpider Beta-Ala-His dipeptidase C00386 KEGG Compound 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS C00020 KEGG Compound C00027 KEGG Compound C00388 KEGG Compound C00025 KEGG Compound Q96KP4 UniProt 501-75-7 CAS 104-98-3 CAS 8.0 Carnosine synthase 1 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P19801 UniProt 1.0 HYDROGEN-PEROXIDE BioCyc 645-65-8 CAS CHEBI:29178 ChEBI HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB P49590 UniProt 1.0 132948 ChemSpider P30838 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C03680 KEGG Compound 763 ChemSpider C01262 KEGG Compound HMDB0000148 HMDB Histamine L-Histidyl-tRNA(His) 1.0 tRNA(His) C6H10N2O4 Formiminoglutamic acid 174.06406 784 PubChem-compound 7732-18-5 CAS HMDB0001487 HMDB 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C01152 KEGG Compound 3614 PubChem-compound AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Adenosine diphosphate CHEBI:29155 ChEBI HMDB0000033 HMDB 774 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Probable histidine--tRNA ligase, mitochondrial Protein arginine N-methyltransferase 3 Beta-Ala-His dipeptidase 530 PubChem-compound Pyrophosphate HMDB0001377 HMDB HMDB0001014 HMDB P12081 UniProt HMDB0000045 HMDB S-Adenosylhomocysteine 1.0 1.0 C5H6N2O Imidazole-4-acetaldehyde 110.04801 83153 ChemSpider Ammonia SMILES NCCC(O)=O UROCANATE BioCyc Amiloride-sensitive amine oxidase [copper-containing] 962 PubChem-compound 31983 ChemSpider 86856 ChemSpider 5800 ChemSpider Histidinemia CO2 Carbon dioxide 43.98983 Hydrogen peroxide HMDB0000056 HMDB HMDB0000177 HMDB C00080 KEGG Compound SMILES O=O Histidine ammonia-lyase Glutamate Metabolism SubPathway HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O