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Pathway Description
Eptifibatide Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2013-08-22
Last Updated: 2019-08-16
Eptifibatide (also named Integrilin) is an anti-coagulant drug that is produced from Sistrurus miliarus barbouri, which can block platelet glycoprotein IIb/IIIa receptor to prevent platelet aggregation. Although, inhibition of platelet aggregation occurs in a dose- and concentration-dependent manner.
References
Eptifibatide Pathway References
Ciccone A, Abraha I, Santilli I: Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD005208. doi: 10.1002/14651858.CD005208.pub2.
Pubmed: 17054247
Jennings LK, Saucedo JF: Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol. 2008 Jul;23(4):302-8. doi: 10.1097/HCO.0b013e3283021ad9.
Pubmed: 18520712
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS: Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. J Biol Chem. 1987 Jun 25;262(18):8476-82.
Pubmed: 2439501
Frachet P, Uzan G, Thevenon D, Denarier E, Prandini MH, Marguerie G: GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. Mol Biol Rep. 1990 Feb;14(1):27-33.
Pubmed: 2345548
Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett JS, Schwartz E, Poncz M: Organization of the gene for platelet glycoprotein IIb. Biochemistry. 1990 Feb 6;29(5):1232-44. doi: 10.1021/bi00457a020.
Pubmed: 2322558
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