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ReactionCatalysis155 ACTIVATION 1.0 Fibrinogen beta chain Coagulation factor V 5284607 PubChem-compound Fondaparinux Action Pathway Fibrin (loose) 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider Antithrombin-III Fibrin (mesh) ReactionCatalysis381 ACTIVATION PW000295 PathWhiz CHEBI:31632 ChEBI Prothrombin and coagulation factors VII, IX and X SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O P00488 UniProt Vitamin K-dependent gamma-carboxylase P02671 UniProt BTO:0000759 BRENDA TISSUE ONTOLOGY Fibrinogen gamma chain Tenase complex Coagulation factor VIII Coagulation factor IX ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 26333246 ChemSpider 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT C31H45N3Na10O49S8 Fondaparinux sodium 1728.7864 ReactionCatalysis1100 ACTIVATION HMDB0014709 HMDB P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C(O)=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C(O)=O)[C@H](O)[C@H]1NS([O-])(=O)=O SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 84-80-0 CAS 49852292 PubChem-compound 91577 PubChem-compound Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII SubPathwayActivator Plasminogen Liver 25486-55-9 CAS Coagulation factor IX P03951 UniProt P03952 UniProt P00451 UniProt 1.0 Extracellular Space Blood Vessel BiologicalState51 Homo sapiens, Blood Vessel Coagulation factor XII GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway C05849 KEGG Compound BiologicalState29 Homo sapiens, Liver 1.0 Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT 1.0 Plasminogen Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 BTO:0001102 BRENDA TISSUE ONTOLOGY 1.0 Fondaparinux sodium SubPathwayActivator 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII Homo sapiens 1.0 Vitamin K-dependent gamma-carboxylase P13726 UniProt Antithrombin-III SubPathwayActivation HMDB0004198 HMDB Q9BQB6 UniProt Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 1.0 P08709 UniProt SMP0000273 SMPDB 9606 TAXONOMY Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII P12259 UniProt P02452 UniProt Coagulation factor XIIIa SubPathwayActivation SubPathwayControl468 ActivatingSubPathwayControl SubPathway468Control 1.0 P05160 UniProt ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V P01008 UniProt ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O Coagulation factor XIII A chain Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Prothrombin and coagulation factors VII, IX and X 1.0 Coagulation factor XI Prothrombin ReactionCatalysis1134 ACTIVATION Plasma kallikrein Tissue-type plasminogen activator Coagulation factor XIIIa Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Fibrinogen beta chain 1.0 Prothrombin P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator 114870-03-0 CAS Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 P00740 UniProt P00742 UniProt Fondaparinux sodium activation of Antithrombin-III ActivatingSubPathway Antithrombin- III Coagulation factor XII Collagen alpha-1(I) chain Coagulation factor XIIa Plasma kallikrein Coagulation factor XIII A chain Coagulation factor XIII B chain Coagulation factor VII Tissue factor Tissue factor:Coagulation factor VIIa Plasma prekallikrein Coagulation factor XIIa Coagulation factor XI Coagulation factor XIa Coagulation factor IX Coagulation factor IXa Coagulation factor VIII Coagulation factor VIIIa Prothrombin Coagulation factor V Coagulation factor Va Prothrombin Coagulation factor X Coagulation factor Xa Prothrombin Thrombin Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibrin (loose) Fibrin (mesh) Coagulation factor XIIIa Fibrin degradation products Plasmin Plasminogen Tissue-type plasminogen activator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Vitamin K-dependent gamma- carboxylase Fondaparinux sodium Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Cortexolone Calcium Calcium Cortexolone Calcium Cortexolone Calcium Calcium Calcium Calcium Calcium Calcium Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Platelet Factor 3 Tenase complex Platelet factor 3 Prothrombinase complex ENDOTHELIAL CELL SUBENDOTHELIUM VASCULAR INJURY ENDOTHELIAL CELL SUBENDOTHELIUM COAGULATION
ReactionCatalysis155 ACTIVATION 1.0 Fibrinogen beta chain Coagulation factor V 5284607 PubChem-compound Fondaparinux Action Pathway Fibrin (loose) 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider Antithrombin-III Fibrin (mesh) ReactionCatalysis381 ACTIVATION PW000295 PathWhiz CHEBI:31632 ChEBI Prothrombin and coagulation factors VII, IX and X SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O P00488 UniProt Vitamin K-dependent gamma-carboxylase P02671 UniProt BTO:0000759 BRENDA TISSUE ONTOLOGY Fibrinogen gamma chain Tenase complex Coagulation factor VIII Coagulation factor IX ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 26333246 ChemSpider 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT C31H45N3Na10O49S8 Fondaparinux sodium 1728.7864 ReactionCatalysis1100 ACTIVATION HMDB0014709 HMDB P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C(O)=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C(O)=O)[C@H](O)[C@H]1NS([O-])(=O)=O SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 84-80-0 CAS 49852292 PubChem-compound 91577 PubChem-compound Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII SubPathwayActivator Plasminogen Liver 25486-55-9 CAS Coagulation factor IX P03951 UniProt P03952 UniProt P00451 UniProt 1.0 Extracellular Space Blood Vessel BiologicalState51 Homo sapiens, Blood Vessel Coagulation factor XII GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway C05849 KEGG Compound BiologicalState29 Homo sapiens, Liver 1.0 Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT 1.0 Plasminogen Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 BTO:0001102 BRENDA TISSUE ONTOLOGY 1.0 Fondaparinux sodium SubPathwayActivator 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII Homo sapiens 1.0 Vitamin K-dependent gamma-carboxylase P13726 UniProt Antithrombin-III SubPathwayActivation HMDB0004198 HMDB Q9BQB6 UniProt Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 1.0 P08709 UniProt SMP0000273 SMPDB 9606 TAXONOMY Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII P12259 UniProt P02452 UniProt Coagulation factor XIIIa SubPathwayActivation SubPathwayControl468 ActivatingSubPathwayControl SubPathway468Control 1.0 P05160 UniProt ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V P01008 UniProt ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O Coagulation factor XIII A chain Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Prothrombin and coagulation factors VII, IX and X 1.0 Coagulation factor XI Prothrombin ReactionCatalysis1134 ACTIVATION Plasma kallikrein Tissue-type plasminogen activator Coagulation factor XIIIa Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Fibrinogen beta chain 1.0 Prothrombin P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator 114870-03-0 CAS Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 P00740 UniProt P00742 UniProt Fondaparinux sodium activation of Antithrombin-III ActivatingSubPathway SERPINC1 F12 COL1A1 F12 KLKB1 F13A1 Unknown F7 Unknown F7 KLKB1 F12 Unknown Unknown F9 F9 F8 F8 Unknown F5 F5 Unknown F10 F10 Unknown Unknown Unknown Unknown FGG Unknown Unknown F13A1 Unknown PLG PLG PLAT F10 VKORC1 GGCX Fondaparinux sodium Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X